Life Extension Update Exclusive
Wake up and smell the coffee
A forthcoming article in the British Journal of Nutrition, published online on December 6, 2007, reported the finding of Finnish researchers that an increased intake of coffee is associated with lower mortality over a 14.5 year period.
Dr Pertti Happonen and associates evaluated data from 311 men and 506 women born during or before 1920 who were part of a large study intended to evaluate falls in older individuals. Physical examinations were conducted upon enrollment between 1991 and 1992, and questionnaires were completed concerning smoking status, the presence of diabetes, amount of coffee intake, and other information. A second questionnaire was completed two to three years later. The participants were followed for mortality through 2005.
Over the follow-up period, 251 deaths occurred among the men, and 372 among women. For total mortality from all causes, and mortality from cardiovascular disease, cancer, and other or unknown causes, there was an association observed between the number of cups of coffee consumed and a decrease in the risk of death. Compared with drinking one to two cups coffee per day, each added cup lowered the risk of mortality by an average of 4 percent. When the follow-up period was divided into five year periods, the strength of coffee’s effect appeared to diminish during the final years of the study, although the researchers add that there was not enough evidence to conclude a constant linear decrease.
In an attempt to provide possible mechanisms for the finding, the authors list several diseases shown to be inversely associated with coffee intake, including Alzheimer’s disease, breast and colorectal cancer, asthma, and diabetes. They note that increased antioxidant capacity is one of coffee’s potential mechanisms against disease, and remark that the polyphenols in coffee are the greatest source of antioxidants in the diet of the Nordic population studied in this research. The effects of caffeine, as well, may have an impact on total mortality.
“The present study in a representative sample of older adults strengthens the findings in some previous studies among middle-aged individuals of a beneficial effect of moderate or heavy coffee consumption on the risk of death,” the authors conclude. “We expect results from more detailed studies in larger study populations to provide more insight about the advantages and disadvantages of coffee consumption, and to set critical recommendations of optimal consumption with regard to health.”
Before insulin, botanical medicines were used to treat diabetes. They are remarkably safe and effective. However, because many botanical medicines function similarly to insulin, people taking oral diabetes medications or insulin should use caution to avoid hypoglycemia. Botanical medicines should be integrated into a regimen of adequate exercise, healthy eating, nutritional supplements, and medical support.
Coffee berry contains some well-studied phytochemicals such as chlorogenic acid, caffeic acid, ferulic acid, and quinic acid (Charles-Bernard M et al 2005). Some of coffee berry’s most impressive effects can be seen in blood glucose management. Chlorogenic acid and caffeic acid are the two primary nutrients in coffee that benefit individuals with high blood sugar. Glucose-6-phosphatase is an enzyme crucial to the regulation of blood sugar. Since glucose generation from glycogen stored in the liver is often overactive in people with high blood sugar (Basu R et al 2005), reducing the activity of the glucose-6-phosphatase enzyme leads to reduced blood sugar levels, with consequent clinical improvements.
Chlorogenic acid has been shown to inhibit the glucose-6-phosphatase enzyme in a dose-dependent manner, resulting in reduced glucose production (Hemmerle H et al 1997). In a trial at the Moscow Modern Medical Center, 75 healthy volunteers were given either 90 mg chlorogenic acid daily or a placebo. Blood glucose levels of the chlorogenic acid group were 15 percent to 20 percent lower than those of the placebo group (Abidoff MT 1999). Chlorogenic acid also has an antagonistic effect on glucose transport, decreasing the intestinal absorption rate of glucose (Johnston KL et al 2003), which may help reduce blood insulin levels and minimize fat storage.
Benfotiamine with Thiamine
One of the most deleterious effects of “normal” aging is rising glucose (blood sugar) levels. Excess glucose floods cells throughout the body, overwhelming their metabolic machinery and increasing the mitochondrial production of free radicals. Failure to control this excess sugar can lead to numerous health issues.
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and acts through several mechanisms to block the biochemical pathways by which high blood sugar wreaks havoc throughout the body.
Enhanced Cinnulin PF® with Glucose Management Proprietary Blend
High blood sugar is implicated in the development of numerous health problems. New studies reveal that even active, health-conscious adults can experience higher than desired blood sugar levels as they age. In addition to a proper diet and regular exercise, certain minerals and plant-based nutrients can help support healthy blood sugar levels in aging adults. Chief among these are pharmaceutical extracts found in cinnamon, coffee berry, green tea, and banaba leaf, a new form of chromium, and water-soluble quercetin.
CoffeeBerry® Forte extract contains chlorogenic acid that inhibits glucose-6-phosphatase, an enzyme involved in the conversion of glycogen (stored sugar) to blood glucose, thus helping to maintain already-normal glucose metabolism.
Life Extension Vacations Second Annual Life Extension Cruise
Our first cruise was so successful that we decided to offer another one in 2008! Attendees told us they were able to learn a lot about the latest in integrative therapies and antiaging research and at the same time have plenty of fun aboard the cruise ship.
This time we will cruise the splendor of the Alaskan wilderness aboard Celebrity’s sumptuous Infinity. You’ll enjoy our Life Extension seminars, one-on-one consultations, a welcome aboard cocktail reception, exceptional personal service, award-winning cuisine, world-famous amenities, accommodations that are the most spacious at sea, and much more.
The second Life Extension Seminar at Sea will be a 7-night cruise on August 29, 2008.
Special features for Life Extension Members:
- Celebrity Concierge Class (191 sq ft) – from $1,973 per person
- Floor-to-ceiling glass doors
- Large sitting area
- Enhanced service
- Priority embarkation/disembarkation
- Fresh fruit and flowers
- Welcome champagne
- Hansgrohe massaging showerhead
Book by January 31, 2008, and receive an exceptional value coupon book with $200 in onboard savings.
For reservations or for more information please call Life Extension Vacations at 800-791-4457 or email firstname.lastname@example.org.
We are looking forward to seeing you onboard!