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April 4, 2008

Increased dietary choline may help reduce breast cancer risk

Increased dietary choline may help reduce breast cancer risk

An article published online on January 29, 2008 in the Federation of American Societies for Experimental Biology (FASEB) journal reported the finding of research funded by the U.S. National Institutes of Health (NIH) that having a greater intake of the B vitamin choline is associated with a reduction in the risk of breast cancer. The article is scheduled for publication in the journal’s June 1 print issue.

Jia Chen and associates compared dietary intake data from 1508 women with breast cancer to 1556 women without the disease. The researchers focused on the intake of betaine (TMG), methionine, and choline, which is an essential nutrient that occurs in eggs, wheat germ and other foods. The nutrients are among those involved in methylation, which plays a role in the development of cancer.

Women whose intake of choline was in the highest one-fifth of participants, at 455 milligrams per day or more, had a 24 percent lower risk of breast cancer than women whose intake was in the lowest fifth at 196 milligrams or less. Coffee, eggs, and skim milk were the most common sources of choline consumed by women in the study. The researchers also noted that two variations in choline-metabolizing genes were related to breast cancer risk.

Only 10 percent of Americans are estimated to meet the Institute of Medicine’s adequate choline intake level of 425 milligrams per day for women and 550 milligrams per day for men and breastfeeding women. “Choline is needed for the normal functioning of cells, no matter your age or gender,” observed study coauthor Steven H. Zeisel, MD, PhD, of the University of North Carolina. “Increasing evidence shows that it may be particularly important for women, particularly those of child-bearing age.”

“While choline is an essential nutrient to the human diet, most people haven’t even heard of it,” FASEB Journal Editor in Chief Gerald Weissmann, MD, added. “Given that in the U.S. there is a real need to understand how much choline we require in our diet, we hope that research, education and awareness about choline will increase as a result of this study published in The FASEB Journal.”

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Health Concern Life Extension Highlight

Breast cancer

The following supplementation regimen is suggested. As always, consult your physician before beginning any nutritional supplementation regimen.

  1. Dual-Action Cruciferous Vegetable Extract With Cat's Claw, 1-2 capsules per day.
  2. Lightly caffeinated green tea extract, three 725 mg capsules, two times a day with meals. Use decaffeinated green tea extract if you are sensitive to caffeine or want to use the less-stimulating version with the evening dosage.
  3. CLA or CLA with Guarana, 3000 to 4000 mg daily of CLA and about 300 mg of guarana, early in the day.
  4. Melatonin, 3 to 50 mg at bedtime.
  5. PhytoFood Powder (broccoli, cabbage, and other cruciferous vegetables that provide sulphoraphane and other cancer-fighting plant extracts), 1-2 tbsp daily.
  6. Se-methylselenocysteine, 200 to 400 mcg daily.
  7. CoQ10, three 100 mg softgels in divided doses. Note the caution stated in this protocol.
  8. Super EPA/DHA w/Sesame Lignans, 8 softgels daily, in divided doses. Take with nonfiber meals.
  9. Vitamin D3, 4000 to 6000 IU taken daily with monthly blood testing to monitor for toxicity. Reduce dosage at 6 months.
  10. Water-soluble vitamin A, 100,000 to 300,000 IU daily with monthly blood testing to monitor for toxicity. Reduce dosage at 6 months (refer to vitamin A precautions in Appendix A).
  11. Vitamin E succinate (tocopheryl succinate), 1200 IU daily.
  12. Gamma E Tocopherol w/Sesame Lignans 1 capsule daily.
  13. Vitamin C, 4000 to 12,000 mg throughout the day.
  14. Gamma linolenic acid, 4 capsules of Mega GLA w/Sesame Lignans.
  15. Whey protein concentrate-isolate, 30 to 60 grams daily in divided doses.
  16. Bone Restore provides calcium, magnesium, and bone-protecting nutrients. Take 5 capsules at bedtime.
  17. Vitamin K, 10 mg daily.
  18. Silicon, 6 mg daily. (Jarrow's Biosil is recommended.)
  19. Life Extension Mix without Copper (multinutrient formula), 3 tablets 3 times daily.

Life Extension Magazine April, 2008 issue now online!

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Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
954 766 8433 extension 7716
www.lef.org