Life Extension Skin Care Sale

Life Extension Update

Life Extension Update Exclusive

November 14, 2008

Vitamin C supplementation lowers C-reactive protein levels

Vitamin C supplementation lowers C-reactive protein levels

An article scheduled to appear in the January 1, 2009 issue of Free Radical Biology and Medicine reports the finding of researchers at the University of California, Berkeley that supplementing with vitamin C reduces C-reactive protein (CRP), a marker of inflammation linked with an increased risk of cardiovascular disease and diabetes.

Berkeley professor emeritus of epidemiology and public health nutrition Gladys Block and her associates randomized 396 nonsmokers to receive 1000 milligrams vitamin C, 800 international units vitamin E, or a placebo for two months. Serum C-reactive protein levels were measured before and after the treatment period.

Although no effects for vitamin E were observable, and no effect for vitamin C was noted among those with desirable CRP levels, for participants with elevated C-reactive protein (defined as 1 milligram per liter or higher), vitamin C lowered CRP by 0.25 milligrams per liter compared to the placebo, a reduction similar to that associated with statin drug treatment.

"This is an important distinction; treatment with vitamin C is ineffective in persons whose levels of CRP are less than 1 milligram per liter, but very effective for those with higher levels," stated Dr Block. "Grouping people with elevated CRP levels with those who have lower levels can mask the effects of vitamin C. Common sense suggests, and our study confirms, that biomarkers are only likely to be reduced if they are not already low."

Dr Block noted that a trial reported earlier this week in the Journal of the American Medical Association, which found no association between supplementation with vitamins C and E and the risk of stroke or heart attack, failed to screen participants for CRP elevation, which is important in the determination of who might benefit from vitamin C.

In another recently reported study ( the Jupiter trial), Harvard Medical School researchers showed that statin drugs reduced cardiovascular disease and cardiovascular mortality in individuals with normal lipids and elevated CRP. The trial found a 37 percent reduction in CRP associated with statins compared to treatment with a placebo. "One of the strengths of the Jupiter trial is that only persons with CRP levels greater than 2 milligrams per liter were enrolled," Dr Block remarked. "Researchers found very important effects of lowering CRP in people who had high levels to begin with."

"Major studies have found that the level of CRP in the body predicts future risk of cardiovascular disease, including myocardial infarction, stroke and peripheral artery disease, as well as diabetes," Dr Block stated. "Some believe CRP to be as important a predictor of future heart problems as high levels of LDL and low levels of HDL cholesterol."

"This is clearly a line of research worth pursuing," she added. "It has recently been suggested by some researchers that people with elevated CRP should be put on statins as a preventive measure. For people who have elevated CRP but not elevated LDL cholesterol, our data suggest that vitamin C should be investigated as an alternative to statins, or as something to be used to delay the time when statin use becomes necessary."

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Chronic inflammation

Seemingly unrelated diseases have a common link. People who have multiple degenerative disorders often exhibit excess levels of pro-inflammatory markers in their blood. Here is a partial list of common medical conditions that are associated with chronic inflammation:

Diseases related to chronic inflammation

Disease

Mechanism

Allergy

Inflammatory cytokines induce autoimmune reactions

Alzheimer's

Chronic inflammation destroys brain cells

Anemia

Inflammatory cytokines attack erythropoietin production

Aortic valve stenosis

Chronic inflammation damages heart valves

Arthritis

Inflammatory cytokines destroy joint cartilage and synovial fluid

Cancer

Chronic inflammation causes many cancers

Congestive heart failure

Chronic inflammation contributes to heart muscle wasting

Fibromyalgia

Inflammatory cytokines are elevated

Fibrosis

Inflammatory cytokines attack traumatized tissue

Heart attack

Chronic inflammation contributes to coronary atherosclerosis

Kidney failure

Inflammatory cytokines restrict circulation and damage nephrons

Lupus

Inflammatory cytokines induce an autoimmune attack

Pancreatitis

Inflammatory cytokines induce pancreatic cell injury

Psoriasis

Inflammatory cytokines induce dermatitis

Stroke

Chronic inflammation promoted thromboembolic events

Surgical complications

Inflammatory cytokines prevent healing

Life Extension Vacations
Ring in the New Year in Spain, Ireland or Italy!

What better excuse to travel than to say goodbye to the old year and welcome the New Year in an exciting destination.

Enjoy roundtrip airfare, first class accommodations, daily breakfast, sightseeing (per itinerary) in modern air-conditioned motor coach, services of English-speaking tour manager, services of local guides in all major cities, entrance fees (per itinerary), and more.

Additional tour packages are available to make this a most memorable dream come true.

8 Day New Year in Spain from $1779
8 Day New Year in Ireland from $1799
10 Day New Year in Italy from $2969

Life Extension Vacations (Operated by Caribbean Islands Travel)

www.LEVacations.com Phone: 1-800-791-4457
Email: reservations@levacations.com
Office operation hours: Mon-Fri 8:30 am to 6:00 pm.

Featured Products

Lactoferrin Capsules

add to cart

A minor fraction of whey, lactoferrin appears to have a wide variety of uses in biological systems and is considered a first line immune defense in the human body. Though a natural component of cows’ and human mothers’ milk, lactoferrin is found throughout the human body.

Published studies that have examined the use of lactoferrin as a supplement and its beneficial effects on immunity have been quite promising. Lactoferrin helps to maintain a proper level of “good” bacteria in the intestinal tract, while controlling the number of “bad” bacteria. Probably lactoferrin’s best-known role is as an iron binding protein. The mechanism appears to lie with lactoferrin’s ability to bind iron, as it is known to have an extremely high affinity for this metal.

Slim Signals™ with Irvingia and Fucoxanthin

add to cart

In order for carbohydrates to be fully absorbed, they must be broken down in the digestive tract by the amylase enzyme. Irvingia inhibits amylase, and thus reduces the amount of ingested starches that will be absorbed as sugar.

Several studies demonstrate the weight loss properties of Irvingia. In the largest placebo controlled human study, those taking Irvingia lost 28 pounds over a 10-week period compared to only up to 3 pounds in the placebo group. The study participants did not alter their diet.

A combination of Integra-Lean™ Irvingia, fucoxanthin, and pomegranate seed oil called SlimSignals™ provides 150 mg of Irvingia in each softgel capsule, plus fucoxanthin and pomegranate seed oil. Fucoxanthin functions to increase nonstimulating thermogenesis (fat burning) in adipocytes, while pomegranate seed oil reduces blood supply to adipocytes.

Note: Supplements should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

News Archive

Life Extension Update

What's Hot

Life Extension magazine

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954 202 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
954 766 8433 extension 7716
www.lef.org