Life Extension Spring Clearance Sale

Life Extension Update

Life Extension Update Exclusive

December 23, 2008

Olive oil polyphenols may help reduce breast cancer risk

Olive oil polyphenols may help reduce breast cancer risk

A report published online on December 18, 2008 in the journal BioMed Central Cancer revealed the discovery of Spanish researchers of a suppressive effect of compounds found in extra virgin olive oil against breast cancer cells containing the cancer gene HER2. HER2 is amplified or overexpressed in an estimated 20 to 30 percent of invasive breast cancers, and is associated with a shorter relapse time and reduced survival.

Javier Menendez of the Catalan Institute of Oncology along with Antonio Segura-Carretero from the University of Granada and colleagues tested phenolic fractions of extra-virgin oil in two cultured human breast cancer cell lines, and left some cells untreated as controls. The team found that fractions containing polyphenols known as lignans and secoiridoids selectively triggered programmed death in cells overexpressing HER2 protein. "Our findings reveal for the first time that all the major complex phenols present in extra-virgin olive oil drastically suppress overexpression of the cancer gene HER2 in human breast cancer cells," Dr Menendez remarked.

Extra virgin olive oil is produced by pressing olives without the use of heat or chemicals, and retains phytochemicals otherwise lost in refinement. Although the authors speculated in their introduction to the article that the intake of significant amounts of olive oil might be responsible in part for the association observed between the consumption of a Mediterranean diet and a reduction in breast cancer risk, they note that, "The active phytochemicals (i.e. lignans and secoiridoids) exhibited tumoricidal effects against cultured breast cancer cells at concentrations that are unlikely to be achieved in real life by consuming olive oil". However, they add that "These findings, together with the fact that that humans have safely been ingesting significant amounts of lignans and secoiridoids as long as they have been consuming olives and extra-virgin oil, strongly suggest that these polyphenols might provide an excellent and safe platform for the design of new anti breast-cancer drugs."

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Breast cancer

Once cancer is diagnosed, there are several tests performed on lymph node or tumor tissue that can be useful in determining a woman's prognosis and for assessing the type of treatment that will be most effective for her specific breast cancer. The issue of which factors are the most reliable at determining a woman's prognosis and predicting her outcome to certain treatments is perpetually under study. As research progresses, certain factors will fall in and out of favor. Only when found to be accurate and reliable does a factor become a part of standard practice. Commonly assessed prognostic and predictive factors include lymph node status, tumor size, and tumor grade, type of cancer, hormone receptor status, proliferation rate, and HER2/neu (also known as erbB2 expression).

HER2 (human epidermal growth factor receptor 2) is a gene found in every cell of the human body, and its purpose is to help a cell divide. The HER2 gene tells a cell to form the HER2 protein on the cell surface. HER2 protein then receives a signal to send a message to the center of the cell, known as the nucleus, that it is time to divide. The HER2 protein is also called the HER2 receptor.

Each healthy breast cell contains two copies of the HER2 gene, which contribute to normal cell function. When a change occurs that causes too many copies of the HER2 gene to appear in a cell, the gene, in turn, causes too many HER2 proteins, or receptors, to appear on the cell surface. This is referred to as HER2 protein overexpression. Patients who are considered HER2-positive have cancer that grows and spreads more rapidly.

HER2 protein overexpression affects about 25% of breast cancer patients and results in a more aggressive form of the disease and earlier disease reappearance; in these cases the disease may not be as responsive to standard therapies. The HER2 status of a tumor is determined by testing tissue removed during a biopsy.

Life Extension Daily News

Current findings published by news media worldwide on the topics of health and wellness, dietary supplements, diseases such as atherosclerosis, arthritis and stroke, and numerous other subjects of interest to those who wish to live a longer, healthier life are posted each day in Life Extension Daily News. New articles posted seven days a week under the headings of vitamins, nutrition, disease and aging cover a range of subjects, from health tips for the lay person to peer-reviewed medical journal reports.

http://www.lef.org/News

 

Life Extension Daily News

Annual Super Sale - The biggest sale of the year
Featured Products

Advanced Lipid Control

add to cart

Safely managing blood lipid levels can be a challenge for people as they get older. Yet an increasing number of doctors recognize the critical need to protect the arterial wall against low-density lipoprotein (LDL) oxidation and inflammatory insults.

For those who want to maintain healthful levels of lipids in the blood, Advanced Lipid Control contains a combination of two powerful nutrients that help protect key aspects of cardiovascular function. This special formula supports healthy cholesterol levels for those already within normal range and safeguards vascular and heart health, while providing excellent antioxidant protection.

Anti-Alcohol Antioxidants with Hepatoprotection Complex

add to cart

When people are exposed to a known toxic substance such as alcohol, it makes perfect sense to take a proven antidote — namely, antioxidants. Life Extension’s Anti-Alcohol Antioxidants with HepatoProtection Complex is an improved formula containing additional antioxidants designed to suppress free radicals, neutralize toxic alcohol metabolites such as acetaldehyde, and support healthy liver function. In addition to vitamin B1, vitamin C, N-acetyl-cysteine and benfotiamine, this formula’s HepatoProtection Complex provides therapeutic doses of these novel antioxidants:

  • Chlorophyllin
  • Leucoselect® grapeseed extract, silymarin (from milk thistle), and resveratrol
  • Picroliv® Picrorhiza kurroa root extract
  • Barley grass powder extract
News Archive

Life Extension Update

What's Hot

Life Extension magazine

Due to the upcoming holiday, there will be no Life Extension Update published on December 26, 2008.  Life Extension would like to wish you all a happy holiday season, and a safe and happy New Year.

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954 202 7716.

For longer life,

Dayna Dye
Editor, Life Extension Update
ddye@lifeextension.com
954 766 8433 extension 7716
www.lef.org