Breast tumors often require hormones for growth, which poses a unique problem because the hormones involved in tumor growth are either estrogen, progesterone, or both. Estrogen and progesterone are naturally occurring and necessary hormones, produced mainly in the ovaries and adrenal glands in varying amounts throughout a woman's lifetime. These hormones are essential for many physiological functions, such as bone integrity. The stronger form of estrogen, estradiol, can be converted into the weaker form, estriol, in the body without using drugs. Estriol is considered to be a more desirable form of estrogen. It is less active than estradiol, so when it occupies the estrogen receptor, it blocks estradiol's strong "growth" signals. Using a natural substance, the conversion of estradiol to estriol increased by 50% in 12 healthy people (Michnovicz et al. 1991). Furthermore, in female mice prone to developing breast cancer the natural substance reduced the incidence of cancer and the number of tumors significantly. The natural substance was indole-3-carbinol (I3C).
Indole-3-carbinol (I3C) is a phytochemical isolated from cruciferous vegetables (broccoli, cauliflower, Brussels sprouts, turnips, kale, green cabbage, mustard seed, etc.). I3C given to 17 men and women for 2 months reduced the levels of strong estrogen, and increased the levels of weak estrogen. But more importantly, the level of an estrogen metabolite associated with breast and endometrial cancer, 16--a-hydroxyestrone, was reduced by I3C (Bradlow et al. 1991).
When I3C changes "strong" estrogen to "weak" estrogen, the growth of human cancer cells is inhibited by 54-61% (Telang et al. 1997). Moreover, I3C provoked cancer cells to self-destruct (kill themselves via apoptosis). Induction of cell death is an approach to suppress carcinogenesis and is the prime goal of cytotoxic chemotherapy. The increase in apoptosis induced by I3C before initiation of new tumor development may contribute to suppression of tumor progression. Nontoxic I3C can reliably facilitate apoptosis (12 week treatment in rats); thus, this phytonutrient may become a standard adjunct in the treatment of breast cancer (Zhang et al. 2003).
Life Extension Vacations
Royal Resorts and Life Extension
Team Up For Your Health
The increasing stress levels that we have all seen or experienced in this last year make it vital to take time to get away, relax and decompress. Studies show that vacationing increases our life span and is a key attribute for a healthy body and mind.
With that in mind, Life Extension and Royal Resorts are pleased to announce a very special offer for Life Extension members. Now, when you reserve 7 Nights at selected Royal Resorts in Cancun, Rivera Maya, St Maarten or Curacao you get up to 2 discounted Nights.
Life Extension has a satellite office located in the Spa at The Royal Sands. Once there or before you arrive, you can sign up for an I-Tronic Analysis (a machine used by NASA to evaluate the health and shape of internal organs and provide a list of food and supplements required for your specific areas of need), ReeVue (Metabolism Readings ), or one of the many Spa services offered.
There is no time like the present.