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Parkinson’s disease is a devastating brain disorder that gradually robs people of the ability to control their own movements. While the causes and cure of this affliction remain elusive, progressive scientists are continuing to unravel this disease.
During Parkinson’s, cells in the parts of the brain that control movement and regulate mood are gradually destroyed. The primary defect in Parkinson’s is a loss of dopaminergic neurons (such as dopamine-producing neurons) in a part of the brain called the substantia nigra. Dopamine is a neurotransmitter that modulates movement (Purves D et al 2001). In Parkinson’s disease, the dopamine-producing nerve cells are destroyed by high levels of oxidative damage (Atasoy HT et al 2004; Ross GW et al 2004). There is evidence that this oxidative damage is, in turn, caused by defects in the cells’ mitochondria, or power-generating centers.
The ideal treatment for Parkinson’s disease would be a neuroprotective agent— a treatment that protects the brain. While no neuroprotective prescription agent has been found, studies suggest that high-dose coenzyme Q10 (CoQ10), a natural agent, may have neuroprotective properties. CoQ10 is known to support mitochondria by enhancing energy levels in the brain, as well as by acting as a powerful antioxidant. In one phase 2 clinical trial, CoQ10 significantly slowed the progression of Parkinson’s disease (Beal MF 2003).
Conventional therapy for Parkinson’s disease focuses on increasing the production and utilization of dopamine. Levodopa, which is the precursor to dopamine, has been the mainstay of Parkinson’s disease therapy since its discovery in the early 1960s. Today, levodopa remains the foundation of Parkinson’s therapy. However, after 5 years, levodopa begins to lose its effectiveness in patients with Parkinson’s disease. If used as the sole treatment, levodopa must then be prescribed in higher and higher doses, leading to more adverse effects and more intense symptoms. Other drugs that target other parts of dopamine production and the utilization cascade are now increasingly prescribed. When used early enough, these drugs can help postpone levodopa therapy.
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†This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
*Prices based on Final Clearance Sale purchase.
Sale ends September 13, 2010
http://www.lef.org/lpages/finalclearance
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