About age 30 to 35, most men (and some women) notice they are gaining weight around the middle. Their pants become tight and at some point no longer fit. The words “pot belly,” “beer belly,” or “spare tire” are sometimes used to describe the medical condition called “abdominal obesity.” This sort of fat accumulation greatly increases the risk of cardiovascular and other diseases.
As it turns out, there is a scientific explanation for the tendency toward abdominal obesity among middle-aged men. As men age, their levels of free testosterone decline, and levels of estrogen and insulin increase. This is partly because aging men convert much of their testosterone into estradiol, a form of estrogen. Of the remaining testosterone, much is bound to sex hormone–binding globulin, a protein in the blood, and is not biologically active. Studies have shown that men with low free testosterone have higher rates of coronary artery disease, mental depression, and dementia (Tan et al 2004).
In women, the relationship between excess body fat, testosterone, estrogens, and progesterone is somewhat more complicated.
It is believed that estrogen reduces lipid oxidation at puberty and in early pregnancy to facilitate efficient fat storage in preparation for fertility, birth and lactation (O'Sullivan et al 2001; Rosenbaum et al 1999). This modification in lipid oxidation enables fat storage without significant changes in dietary fat and caloric intake (O'Sullivan et al 2001).
The drop in gonadal estrogen production at menopause is associated with an increase in the waist to hip ratio and an increase in size of visceral adipose tissue, and administration of estrogen to postmenopausal women is associated with a lowering of the waist to hip ratio (Rosenbaum et al 1999). However, as women age, levels of progesterone and all estrogens (including estriol, estradiol, and estrone) decline. Progesterone declines much more rapidly than do the estrogens, leading to “estrogen dominance” (Lee et al 1999). Life Extension believes the imbalance of estrogens and progesterone may play a pivotal role in the dynamics of metabolic obesity and visceral fat accumulation in aging women.
The LE weight loss plan begins with comprehensive blood testing to help determine which hormones are low and whether thyroid function needs to be supported. You can order the suggested hormone profile blood tests over the telephone, (800) 208-3444, or on a special website (www.lef.org/blood).
Events – September 25, 2010
Breast Cancer: The untold story
Innovative approaches for prevention and control
8:30 am - 3:00 pm
Hyatt Regency Ballroom
1000 Boulevard of the Arts
Sarasota, FL 34236
- Learn about a pain-free, radiation-free test to detect potential breast cancer 8-10 years before mammography can find it!
- Learn which vitamin can reduce breast cancer risk by 77%
- Learn what to avoid to decrease your risk by 83%
- Learn what foods reduce recurrence by 40%
- Learn which food can balance estrogen levels in 7 days!
- Learn coping styles that can increase survival by 500%
Whether you wish to prevent breast cancer, prevent its recurrence, or need support during or after treatment, this empowering seminar is for you!
Charles K. Bens, PhD
Healthy at work
Stanley Headley, MD, ND
Thermal Health Screening
Susan Silberstein, PhD
Center for Advancement in Cancer Education
Topics to be covered:
Introduction: How cellular changes promote cancer
Breast cancer: The diet connection
Nutritional supplements that really work
Breast cancer: The stress connection
Safe early screening and monitoring with thermal imaging
Before Aug 15: $40
After Aug 15: $50
888-737-9617 http://www.behealthyatwork.com/breastcancer.html http://www.lef.org/event.htm