The human body is certainly no less of a high-performance engine than that of an airplane or car. Yet, although we appreciate the preventive maintenance that is part of the strategy of engine survival, we are inconsistent when we too often ignore the needs of our own bodies--that is, until we have signs of engine breakdown. As many of us love our cars and care for them, we must do the same with our bodies.
Selenium intake of at least 200 mcg a day should be a consideration in the prevention of prostate cancer (PC). Low plasma selenium is associated with a four- to fivefold increased risk of PC. In addition, levels of plasma selenium also decrease with age, resulting in middle-aged to older men being at a higher risk for low selenium levels. Ideally, baseline levels of selenium should be obtained before beginning routine selenium supplementation. It would make sense to begin such a micronutrient and mineral assessment at age 25 and perhaps every 10 years thereafter.
A large-scale study of almost 11,000 men in Maryland showed that the protective effects of high selenium levels, and similarly that of the alpha-tocopherol isomer of vitamin E, were only observed when the concentrations of the gamma tocopherol isomer of vitamin E were also high. In this study, the risk of prostate cancer declined with increasing concentrations of alpha-tocopherol, with the highest concentration associated with a 68% PC risk reduction. For gamma-tocopherol, men with levels in the highest fifth of the distribution had a fivefold greater reduction in the risk of developing PC than men in the lowest fifth (p = .002). The observed interaction between alpha-tocopherol, gamma-tocopherol, and selenium suggested that combined alpha- and gamma-tocopherol supplements, used in conjunction with selenium, should be considered in future PC prevention trials.
In another study, vitamin E succinate inhibited cell growth of PC cells in the LNCaP line by suppressing androgen receptor expression and PSA expression. The combination of Eulexin (flutamide) with vitamin E succinate resulted in a more significant inhibition of LNCaP cell growth. The same investigators demonstrated that selenomethionine also showed an inhibitory effect on LNCaP cell growth but that this appeared to be independent of androgen receptor or PSA pathways.
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Spend November 17th- 21st, 2010 at The Steven Breuer Conference Center in sunny Malibu, California. FITCAMP package prices start at $1,595 (excluding airfare). For more information and to obtain the FITCAMP schedule, visit www.fitcamp.com.
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