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November 19, 2010

New studies concur that cardiovascular disease is primarily the result of lifestyle

Isoflavone-derived drug inhibits prostate tumor metastasis

On November 15, 2010, the American Heart Association Scientific Sessions 2010 featured presentations of the results of two studies which indicate that lifestyle has a greater impact on whether one will develop cardiovascular disease than being genetically predisposed to acquire the disease.

In the first study, researchers at Northwestern University Feinberg School of Medicine evaluated data from 2,336 men and women aged 18 to 30 upon enrollment in the Coronary Artery Risk Development in Young Adults longitudinal study sponsored by the National Heart, Lung and Blood Institute. Diet, physical activity, alcohol intake, smoking status, weight, and blood pressure and glucose levels were assessed at the beginning of the study and at the seventh and twentieth years of follow-up.

Among participants who maintained five healthy lifestyle factors (having a healthy body mass index, limiting alcohol consumption, consuming healthy amounts of potassium, calcium and fiber and a low intake of saturated fat; participating in regular exercise, and never smoking) 60 percent had a low risk profile for cardiovascular disease after 20 years. That percentage dropped to 37 percent for those who had four factors, 30 percent for three factors, 17 percent for two and 6 percent for one or none. Separate analyses for men, women, Caucasians and African-Americans turned up similar findings.

The second study, also conducted at Northwestern University, analyzed three generations of families enrolled in the Framingham Heart Study. The researchers determined that the majority of cardiovascular disease that developed in the subjects was caused by lifestyle factors, with only a small proportion due to heredity. “What you do and how you live is going to have a larger impact on whether you are in ideal cardiovascular health than your genes or how you were raised," lead author and Feinberg School postdoctoral fellow in preventive medicine Norrina Allen concluded.

“Health behaviors can trump a lot of your genetics,” noted Donald Lloyd-Jones, MD, who is the chair and professor of preventive medicine at Northwestern Medicine and a cardiologist at Northwestern Memorial Hospital. “This research shows people have control over their heart health. The earlier they start making healthy choices, the more likely they are to maintain a low-risk profile for heart disease.”

“We really need to encourage individuals to improve their behavior and lifestyle and create a public health environment so people can make healthy choices,” he added. “We need to make it possible for people to walk more and safely in their neighborhoods and buy fresh affordable fruit and vegetables in the local grocery store. We need physical activity back in schools, widely applied indoor smoking bans and reduced sodium content in the processed foods we eat. We also need to educate people to reduce their calorie intake. It’s a partnership between individuals making behavior changes but also public health changes that will improve the environment and allow people to make those healthy choices.”

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Health Concern Life Extension Highlight

Coronary artery disease and atherosclerosis

Atherosclerosis is a far-reaching disease with devastating consequences. Life Extension’s program for reducing the risk associated with atherosclerosis is based on aggressive measures to promote a healthy endothelium and reduce risk factors associated with coronary artery disease. Because all adults are at risk of atherosclerosis, all adults should make the necessary lifestyle changes to protect their arteries. This means getting adequate exercise under the supervision of a physician and eating a diet rich in fruits and vegetables and low in saturated fat. Also, weight loss by obese and overweight adults is an important element in reducing risk of atherosclerosis.

People who have risk factors for atherosclerosis should take measures to modify them. The ideal nutritional approach to atherosclerosis takes into consideration all existing risk factors and attempts to modify each one.

Blood testing is a very important part of any risk-reduction program for coronary heart disease. Healthy adults should have their blood tested at least once a year. People who have heart disease or multiple risk factors should have their blood tested twice a year to monitor their progress. A comprehensive blood test will measure levels of blood lipids, C-reactive protein, homocysteine, fibrinogen, and other blood markers. Regular blood pressure monitoring is also important. Life Extension recommends an optimal blood pressure reading of 119/75. Life Extension also recommends that people aim for low levels of C-reactive protein, LDL, homocysteine, and other markers of disease.

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Life Extension Clinical Research

Life Extension Clinical Research, Inc. is a research organization engaged in cutting-edge clinical research focused on extending the healthy human life span. The organization’s mission includes not only finding solutions to disease and methods of disease prevention, but also improving the health and well-being of humans through innovative clinical research studies. These studies are designed to explore the efficacy and potential of innovative nutraceutical dietary supplements, cosmeceuticals, pharmaceuticals and medical devices that may enhance and optimize health and nutrition. Visit us often to learn about current, as well as upcoming, clinical research studies and learn how to take part in them!

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