Whole Body Health Sale

Life Extension Update

Life Extension Featured Article

December 17, 2010

Hot flashes reduced by folic acid

Hot flashes reduced by folic acid

A trial described in an article in the September, 2010 issue of the journal Gynecological Endocrinology found that the B vitamin folic acid significantly reduced the number and intensity of hot flashes experienced by a group of menopausal women.

Hot flashes, characterized by an unpleasant sensation of excessive heat, occur in up to 75 percent of menopausal women and are linked to a reduction in estrogen levels. While hormone replacement therapy is helpful in alleviating hot flashes, some women prefer to avoid it.

Brain release of the hormone norepinephrine (noradrenaline) and its metabolite 3-methoxy 4-hydroxy phenyl glycol (MHPG) has been found to be higher in women who experience hot flashes than in those who do not. Based on the findings of other research, Ayman A. A. Ewies of The Ipswich Hospital NHS Trust in Suffolk, England and colleagues "hypothesised that folic acid could ameliorate hot flushes by interacting with monoamine neurotransmitters in the brain; therefore, this study was conducted to examine the effect of folic acid supplementation on the occurrence of hot flushes and the plasma level of MHPG in postmenopausal women."

The researchers divided 46 women suffering from hot flashes to receive 5 milligrams folic acid or a placebo daily for four weeks. Plasma MHPG levels were measured before and after treatment. Nine of the women (39.1 percent) who received folic acid experienced complete elimination of hot flashes, and 6 (21 percent) had moderate improvement. In the placebo group, only 1 woman experienced a complete response, while 84.2 percent had no benefit. Participants who received folic acid also experienced a corresponding reduction in plasma MHPG compared to levels measured in those who received the placebo. A review of the participants 2 weeks after the end of the treatment period found that hot flashes returned in all subjects who had experienced improvement when supplementing with folic acid.

"To our knowledge, this is the first study to report the effect of folic acid supplementation on hot flushes in postmenopausal women," the authors announce. "Our study suggests that short-term supplementation with folic acid causes subjective improvements of hot flushes in some postmenopausal women probably by lowering the increased central noradrenergic activity as indicated by the reduced plasma level of its metabolite."

"Although the data are encouraging, the long-term merits of folic acid and the ideal dosage have to be assessed in a multi-centre, randomised, placebo-controlled trial of appropriate size and duration," they add.

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Female Hormone Restoration

For most women, menopause is known chiefly through its side effects. Up to 85 percent of Western women experience menopausal symptoms, including hot flashes, night sweats, disturbed sleep, fatigue, and related psychological changes, such as depression and anxiety (Burd et al 2001; Mahady et al 2002; Philp 2003; Soares et al 2003). Physical changes include urinary tract atrophy, vaginal atrophy and dryness with discomfort during sexual intercourse (Burger 2001; Coope 1996; Griffith 2004). These uncomfortable symptoms can last up to five years, with an average duration of two to three years (Samsioe 1995). Other symptoms include the following:

  • Strength, energy, muscle, and bone loss (Notelovitz 2002; Proctor et al 1998)
  • Cognitive changes, such as decreased memory, lack of concentration, and decreased learning capacity (Bhavnani 2003; Duffy et al 2003; File et al 2001; Lephart et al 2002)
  • Elevated cholesterol levels due to alterations in cholesterol metabolism, as well as hardening of the arteries (atherosclerosis) and increased blood pressure (Philosophe et al 1991). Estrogen deprivation is a contributing factor to cardiovascular disease, the leading cause of death of women (Brochier et al 1998). It has been hypothesized that elevated cholesterol may be connected to falling hormone levels because the body tries to compensate for lost hormones by increasing the supply of precursor cholesterol (Dzugan et al 2002).

Native American Indians have used black cohosh as a traditional medicine for many years, and Koreans have used it to treat pain and inflammation (Huntley 2004; Kim et al 2004; McKenna et al 2001). Today, it is used primarily for the treatment of menopausal symptoms, such as hot flashes, and menopausal depression and anxiety (Kennelly et al 2002). Black cohosh has also been used to treat younger women who have surgically induced hormonal deficits due to hysterectomy or ovariectomy and for menstrual disorders (McKenna et al 2001). It is effective for reducing hot flashes, night sweats, fatigue, and insomnia (Kronenberg et al 2002; Philp 2003; Pockaj et al 2004).

Super Sale

Super Sale on Now!

The Life Extension Foundation Buyers Club is celebrating its 22nd Annual Super Sale! This is your big chance to stock up on vitamins, minerals, hormones, nutrition and weight loss supplements, even skin care. All our formulations are on sale through January 31, 2011. Over 300 breakthrough products … many years ahead of the commercial marketplace … are all available to you right now at our lowest prices of the year!†

*Buy More. Save More! Prices below are based on Super Sale quantity member discount:

PQQ Caps with BioPQQ™
10 mg, 30 vegetarian capsules

Item #01500

$24.00
$14.85*

Calorie Control
Weight Management Formula
402 grams powder

Item #01493

$56.00
$29.70*

Vitamin D3
5000 IU, 60 capsules

Item #00713

$11.00
$6.68*

Super Ubiquinol CoQ10 with
Enhanced Mitochondrial Support™
100 mg, 60 softgels

Item #01426

$62.00
$35.10*

Cognitex Basics
60 softgels

Item #01421

$38.00
$21.60*

Call 1-800-544-4440 or go to www.LifeExtension.com/SuperSale to order now.

*Price based on multi-bottle purchase.
†Excludes membership, renewals, subscriptions fees, gift cards and blood testing.

Featured Products

Creatine Capsules

add to cart

Creatine exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions. Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake.

  1. Optimizing energy metabolism by maintaining higher levels of the body’s energy compound adenosine triphosphate or ATP
  2. Increasing myofibrillar mRNA content and protein synthesis, and reducing amino acid oxidation and protein breakdown
  3. Increasing satellite cell and myonuclei number and activity in human skeletal muscle
  4. Preventing tissue damage by stabilizing cellular membranes and maintaining reserves of ATP

Creatine Whey Glutamine Powder

add to cart

Whey protein isolate can build lean muscle and prevent protein breakdown. Studies suggest whey protein isolate as a useful supplement for muscle recovery and immune regulation for athletes. In addition, protein supplementation may help enhance muscle protein anabolism and provide a means of reducing the progressive loss of muscle mass with age. It has also been shown to enhance the production of glutathione, the body’s natural antioxidant.

Long used by athletes to improve strength and exercise performance, creatine is being recognized as more than a muscle-building supplement. Creatine is present in the body. Skeletal muscles, the heart, brain, and other tissues metabolize creatine and use it as a major energy storage form. Creatine boosts levels of ATP in the mitochondria, the cells’ energy powerhouses.

News Archive

Life Extension Update

What's Hot

Life Extension Magazine®

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954 202 7716.

www.lef.org
Sign up for Life Extension Update

For Customer Service inquiries, please email customerservice@lifeextension.com or call 1 800 678 8989.

For copyright permission, please refer to Life Extension copyright policy.