Life Extension Blood Test Super Sale

Life Extension Update

Life Extension Featured Article

August 9, 2011

Garlic and grape seed supplementation associated with fewer blood cancers

Garlic and grape seed supplementation associated with fewer blood cancers

An article published online on July 29, 2011 in the journal Cancer Epidemiology, Biomarkers & Prevention reveals a link between increased use of garlic, grape and multivitamin supplements and a lower risk of hematologic malignancies, including Hodgkin and non-Hodgkin lymphomas, leukemia and myeloma.

Researchers from Fred Hutchinson Cancer Research Center and the University of Washington in Seattle examined data from 66,227 men and women aged 50 to 76 enrolled in the VITamins And Lifestyle (VITAL) study, which was created to evaluate the impact of dietary supplement use on cancer risk. Responses to questionnaires completed by the participants between 2000 and 2002 were used to estimate ten year average daily dose of each supplemental vitamin, mineral or specialty supplement consumed prior to enrollment.

Five hundred eighty-eight hematologic malignancies were identified among the study subjects through December, 2008 via cancer registry data. Among those who reported using garlic supplements for at least four days a week over three or more years, there was a 45 percent lower adjusted risk of a hematologic cancer compared to those who reported no use. For grape seed extract, the risk was 43 percent lower in those who reported ever using the supplement compared to nonusers. Daily use of multivitamin supplements for at least eight years was associated with a non-significant 20 percent lower risk of hematologic malignancies in comparison with no use.

Possible mechanisms for garlic include modulation of carcinogen metabolism, protection against DNA damage, improved antioxidant defenses and DNA repair, and increased programmed cell death of cancer cells. Grape seed is an additional source of antioxidants, and possesses anti-inflammatory properties.

"This is the first cohort study to suggest a possible role of these supplements in the chemoprevention of hematologic malignancies," the authors announce. "Our findings suggest a possible role of these supplements in the chemoprevention of hematologic malignancies, but further, controlled studies will need to confirm these findings."

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Lymphoma

There are two types of lymphoma (Hansmann ML et al 1996):

  • Hodgkin's lymphoma, also known as Hodgkin's disease (HD)
  • Non-Hodgkin's lymphoma (NHL).

Hodgkin's lymphoma begins in the lymph nodes and is characterized by the presence of Reed-Sternberg cells, which are large, cancerous cells that increase in number with disease progression (Harris NL 1999; Kuppers R et al 2002). Evidence suggests that B lymphocytes (B-cells), the infection- and tumor-fighting cells that produce antibodies, produce Reed-Sternberg cells (Brauninger A et al 1999; Harris NL 1999; Kuppers R et al 2002). However, T lymphocytes (T-cells) have also been implicated in rare cases (Kuppers R et al 2002).

Non-Hodgkin's lymphoma describes all lymphoma types without Reed-Sternberg cells (Coffey J et al 2003; Jimenez-Zepeda VH et al 1998). NHL develops as a result of malignant B and T lymphocytes (white blood cells). B-cell lymphomas are more common and account for over 85 percent of NHL cases (Coffey J et al 2003).

Nutritional supplements with demonstrated activity against lymphoma cells include:

  • Curcumin
  • Soy extract
  • Vitamins A, C, D, and E
  • Green tea
  • Resveratrol
  • Ginger
  • Fish oils
  • Garlic

Resveratrol, a naturally occurring substance found in grapes, blocks the growth of lymphoma cells and also increases their rate of cell death (Bruno R et al 2003; Park JW et al 2001). Resveratrol sensitizes chemotherapy-resistant lymphoma cells to treatment with paclitaxel-based chemotherapy (Jazirehi AR et al 2004). Resveratrol also reduces the production of growth factors such as VEGF and IL-8, and theoretically should be beneficial in reducing the ability of lymphoma cells to spread to other organs (Dulak J 2005).

Garlic extracts can induce death in lymphoma cells (Arditti FD et al 2005; Scharfenberg K et al 1990). Indeed, in a recent study, conjugation of a garlic extract to the antibody rituximab (which targets lymphoma cells) led to the death of these cells (Arditti FD et al 2005).

Fitness Summer Sale 2011
Get fit for life—save up to 65%!

Fitness Summer Sale

You can live healthier longer. It's largely up to you. Just pay attention to what you eat … how you exercise … how you nurture and nourish your body.

Start by working out a fitness regimen that fits you. It's summer … time to get moving. So, lace up your walking shoes. Jump on that bike. Dive in to your personal fitness regimen. And refine it as you go. Like your life, it's a work in progress.

Prelox® Natural Sex for Men®
60 tablets

Item #01373

$50.00
$20.00

Mega Green Tea Extract
Lightly Caffeinated*
100 vegetarian capsules

Item #00953

$28.00
$11.20

Mega Green Tea Extract
Decaffeinated*
100 vegetarian capsules

Item #00954

$28.00
$11.20

Creatine Capsules
120 capsules

Item #00609

$10.95
$5.48

Creatine Powder
500 grams

Item #00610

$29.00
$14.50

Branched Chain Amino Acids
90 vegetarian capsules

Item #01253

$19.50
$7.80

Take advantage of this sale today and enjoy up to a 65% savings. To order any of these premium-quality products today, call toll-free 1-888-895-4764 or simply order online.

*This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

http://www.lef.org/lpages/LEFitness/

Featured Products

The Future of Aging, edited by Gregory M. Fahy et al.

add to cart

Last year, the minds at Life Extension® and a host of other scientific and medical research organizations came together to produce The Future of Aging—Pathways to Human Life Extension. This project is more than just a guidebook: it can be taken as a visionary blueprint for extending our life span and redefining our place in a radically transformed society, as predicted by the best brains in the science of aging.

Aging research (biogerontology) has seen staggering exponential advances in the last decade, but the contributors to The Future of Aging have come together for the first time in a single volume to make the convincing case that we are still in the beginning stages, and indeed the best is yet to come. They assert that we are in the midst of a crucial period in the study of aging: millions of post-World War II baby boomers are about to enter the American long-term health care system and the economic costs could potentially cripple an already severely strained economy. Accordingly, this guide is not only indispensable; the timing for it has never been more urgent.

Mega GLA with Sesame Lignans


add to cart

Omega-6 fatty acids are well-supplied in the diet by meat and vegetable oils. However, not all omega-6 fatty acids are of equal value. Arachidonic acid (AA) tends to be unhealthy because it is the precursor of inflammatory eicosanoids—such as prostaglandin E2 (PGE2), thromboxane A2, and leukotriene B4—which promote inflammation. In contrast, gamma-linolenic acid (GLA), found in evening primrose oil, borage oil, and black currant oil, is an important fatty acid that plays a beneficial role in healthy prostaglandin (PGE1) formation and pro-inflammatory mediator reduction.

Numerous studies document GLA's multiple health effects. Enhancing this supplement with sesame lignans enables GLA to work much better in the body, allowing many more people with inflammatory-related problems to benefit from supplemental GLA.

News Archive

Life Extension Update

What's Hot

Life Extension® Magazine

Prelox® is a registered trademark of Horphag Research Ltd. Prelox® is protected by U.S. patent #6,565,851B2.

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954-202-7716.

www.lef.org
Sign up for Life Extension Update

For Customer Service inquiries, please email customerservice@lifeextension.com or call 1 800 678 8989.

For copyright permission, please refer to Life Extension copyright policy.