Whole Body Health Sale

Life Extension Update

Life Extension Featured Article

September 20, 2011

Higher lignan levels improve breast cancer survival

Higher lignan levels improve breast cancer survival

In an article published online on September 6, 2011 in the Journal of Clinical Oncology, German researchers report that high serum levels of enterolactone, a biomarker of lignan intake, are associated with a significantly greater chance of surviving postmenopausal breast cancer in comparison with having low levels. Lignans are phytoestrogen compounds found in flax and other seeds, in addition to vegetables and wheat. These compounds are converted in the colon to enterolactone, which is then absorbed into the bloodstream.

Serum enterolactone levels were measured in blood samples obtained between 2002 to 2005 from 1,140 postmenopausal women with breast cancer. Incidences of tumor metastasis or patient death were documented over a 6.1 median follow-up period.

One hundred sixty-two deaths occurred over follow-up. The median enterolactone level for survivors was 21.4 nanomoles per liter (nmol/L), compared to 17.0 nmol/L for those who did not survive. Women whose enterolactone levels were among the top 25 percent of participants had a 42 percent lower risk of dying over follow-up compared to those whose levels were among the lowest fourth. Subjects whose lignan intake was highest experienced a similarly reduced risk of undergoing metastasis. Further analysis determined a protective effect for enterolactone on estrogen receptor-negative tumors as opposed to those which were receptor-positive.

"We now have first clear evidence showing that lignans lower not only the risk of developing postmenopausal breast cancer, but also the mortality risk," stated lead researcher Jenny Chang-Claude of the German Cancer Research Center in Heidelberg. "The result was significant only for the group of tumors that have no receptor for the estrogen hormone. This gives reason to suspect that enterolactone protects from cancer not only by its hormone-like effect … In order to find out whether enterolactone also inhibits the aggressiveness of estrogen receptors in estrogen-positive tumors, we would need to expand this study to include much larger groups of women."

"By eating a diet that is rich in wholemeal products, seeds and vegetables, which is considered to be health-promoting anyway, everybody can take in enough lignans," she recommended.

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Breast cancer

Breast cancer cells frequently metastasize to the bone, where they cause severe degradation of bone tissue. Metastatic cancer affects more than half of all women during the course of their disease. Bone metastases are a significant cause of morbidity due to pain, pathological fractures, hypercalcemia (abnormally high levels of calcium in blood plasma), and spinal cord compression. The bisphosphonates, including alendronate (Fosamax), tiludronate (Skelid), pamidronate (Aredia), etidronate (Didronel), risedronate (Actonel), ibandronate, and zoledronic acid (Zometa), are a class of drugs that protect against the degradation of bone, primarily by inhibiting osteoclast-mediated bone resorption (bone breakdown).

Bisphosphonates are analogs of a naturally occurring compound, called pyrophosphate, which serves to regulate calcium and prevent bone breakdown. Bisphosphonates are a major class of drugs used for the treatment of bone diseases as they have a marked ability to inhibit bone resorption. Bisphosphonates are considered standard care for tumor-associated hypercalcemia and have been shown to reduce bone pain, improve quality of life, and to delay and reduce skeletal events (Hortobagyi 1996; Roemer-Becuwe et al. 2003).

The renewal of bone is responsible for bone strength throughout our life. Old bone is removed (resorption) and new bone is created (formation). This process is called bone remodeling. Healthy bone is continually being remodeled. Two main types of cells are responsible for bone renewal: the osteoblasts involved in bone formation and the osteoclasts involved in bone resorption. There are several stages involved in bone remodeling. The first is activation. This process involves preosteoclasts that are stimulated and differentiated under the influence of cytokine and growth factors to mature into active osteoclasts. The next step is resorption, in which osteoclasts digest mineral matrix (old bone). The third step is reversal, which ends resorption and signals for the final phase, formation. During this stage, osteoblasts are responsible for bone matrix synthesis (collagen production). Two other noncollagenous proteins are also formed: osteocalcin and osteonectin, together they form new bone.

In patients with bone metastases, bone resorption by the osteoclasts is increased and exceeds bone reformation. Calcium lost from the bones appears in increased amounts in the patient's blood serum and urine. This increase in bone resorption may result in pain, bone fractures, spinal cord compression, and hypercalcemia.

A new age of science delivers the formulas for youth at any age at 60%-70% off!

Fall Skin Care Sale

These nurturing, anti-aging products would be a smart choice at any price. But at 60%-70% off you get far more science and far more solutions for far less. So stock up now and start pampering and protecting your skin to give you that fresh look of youth! Call toll-free 1-866-595-6577 to order now.

Cosmesis Skin Stem Cell Serum
1 ounce

Item #80130

$74.00
$29.60

Anti-Glycation Serum with Blueberry & Pomegranate Extracts
1 ounce

Item #80134

$33.00
$13.20

TAL•SHI™ Foaming Facial Cleanser
5.5 ounces

Item #80974

$22.95
$6.89

Ever Young Bundle
(contains Ultra Rejuvenight, Antioxidant Facial Mist Hydrator Travel Size, Advanced Under Eye Serum with Stem Cells and free gift!)
Item #EYKIT

$137.10*
$45.97

Beautiful Necessities Bundle
(Dry-Normal Skin)

(contains Skin Restoring Ceramides with Lipowheat™, Hyaluronic Facial Moisturizer, TAL•SHI™ Foaming Facial Cleanser and free gift!)
Item #BNDNKIT

$123.80*
$38.09

Beautiful Necessities Bundle
(Oily Skin)

(contains Skin Restoring Ceramides with Lipowheat™, Hyaluronic Oil-Free Facial Moisturizer, TAL•SHI™ Foaming Facial Cleanser and free gift!)
Item #BNOKIT

$123.80*
$38.09


*Includes value of free gift.
http://www.lef.org/SkinCare/

Featured Products

Mega Lycopene

add to cart

Lycopene may be an important substance in maintaining prostate health. A clinical trial demonstrated that lycopene at a dose of 15 mg per day can significantly improve markers of prostate proliferation. In addition, the strong lipid antioxidant properties of lycopene make it particularly effective in maintaining healthy LDL oxidation and protecting against free radical activity on the arterial wall. Improved tomato extraction methods have given consumers access to supplements that contain greater concentrations of lycopene at lower prices.

Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean®


add to cart

Even a modest increase in fat pounds can have an impact on overall health, especially when it's stubborn belly or visceral fat.

To help maturing individuals deal effectively with this serious health issue, Life Extension® introduces a new, clinically validated solution: Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean® African Mango Irvingia. After careful scientific analysis of over 1,000 plant extracts, researchers identified the two species included in AdipoStat that target adipocytes: Sphaeranthus indicus flower and the mangosteen fruit (Garcinia mangostana). Optimal results were shown in studies when these two plant extracts were combined.

News Archive

Life Extension Update

What's Hot

Life Extension® Magazine

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to ddye@lifeextension.com or call 954-202-7716.

www.lef.org
Sign up for Life Extension Update

For Customer Service inquiries, please email customerservice@lifeextension.com or call 1 800 678 8989.

For copyright permission, please refer to Life Extension copyright policy.