Life Extension Final Clerance Sale

Life Extension Update

Poor vitamin B12 status impacts brain volume and function

Poor vitamin B12 status impacts brain volume and function

Tuesday, September 27, 2011. The September 27, 2011 issue of the journal Neurology® reveals an association between unfavorable serum markers of vitamin B12 status and reduced brain volume and cognitive function.

The current investigation was limited to 121 participants in the Chicago Health and Aging Project who had magnetic resonance imaging (MRI) scans of their brains performed several years after undergoing tests of cognitive function. The tests included seven measures of episodic memory, two measures of visuospatial ability or perceptual organization, two measures of perceptual speed, two measures of semantic memory, and three measures of working memory. Stored serum samples were analyzed for vitamin B12 and the vitamin B12 markers methylmalonic acid (MMA), 2-methylcitric acid, homocysteine and cystathionine (generated from homocysteine).

While serum vitamin B12 itself was not associated with cognitive function or measures of brain volume, other indicators of vitamin B12 insufficiency were associated with poor global cognitive test scores and a decrease in brain volume revealed by MRI findings compared to those with better B12 status. When individual cognitive domains were analyzed, decreased episodic memory and perceptual speed were associated with an increase in methylmalonic acid (which is elevated in 90 to 98 percent of men and women with a vitamin B12 deficiency), and poorer episodic and semantic memory were correlated with greater 2-methylcitric acid and cystathionine levels. Higher levels of the vitamin B12 markers, but not serum vitamin B12, were associated with decreased total brain volume, and higher homocysteine levels were associated with greater white matter hyperintensity volume, which is associated with an elevated risk of cerebrovascular events.

Concerning the lack of an association between serum vitamin B12 itself (as opposed to B12 markers) and cognitive function or brain volume, lead author Christine C. Tangney, PhD, of Rush University Medical Center remarked that low levels of vitamin B12 can be challenging to detect in older individuals when only serum vitamin B12 is measured. "Marginal vitamin B12 status in older age is frequently missed by measurement of serum vitamin B12 levels alone," Dr Tangney and her colleagues write. "Our findings suggest that MMA, the specific marker of B12 deficiency, may affect cognition by reducing total brain volume whereas the effect of homocysteine on cognition may be mediated through increased white matter hyperintensity volume and cerebral infarcts."

"Our findings definitely deserve further examination," Dr Tangney said. "It's too early to say whether increasing vitamin B12 levels in older people through diet or supplements could prevent these problems, but it is an interesting question to explore. Findings from a British trial with B vitamin supplementation are also supportive of these outcomes."

shadow
What's Hot Highlight

Soy peptide aids in blocking metastasis

Soy peptide aids in blocking metastasis

An article published online on September 10, 2011 in the journal Cancer Letters describes the discovery of Elvira Gonzalez de Mejia and Vermont P. Dia of the University of Illinois in Urbana of a benefit for lunasin, a peptide that occurs in soy, in preventing the spread of colon cancer to the liver, the predominant site of metastasis for this type of cancer. "When lunasin was used in combination with the chemotherapy drug oxaliplatin, we saw a sixfold reduction in the number of new tumor sites," revealed Dr de Mejia, who is an associate professor of food chemistry and food toxicology at UI.

The current study utilized mice bred to develop colon cancer that metastasizes to the liver. The researchers divided the animals to receive daily injections of lunasin, lunasin plus the chemotherapy drug oxaliplatin, oxaliplatin alone or neither compound. "The group that received lunasin alone had 50 percent fewer metastatic sites," reported Dr de Mejia. "But an even more exciting result was seen in the group that received both lunasin and the chemotherapy drug—only 5 new cancer sites when compared with 28 in the control group."

"This huge reduction in metastasis was achieved with the amount of lunasin in only 25 daily grams of soy protein, the amount recommended in the FDA health claim," noted Dr Dia, who is a University of Illinois postdoctoral fellow. "In this study, we have learned that lunasin can penetrate the cancer cell, cause cell death, and interact with at least one type of receptor in a cell that is ready to metastasize."

"Two glasses of soy milk a day generally provide half the amount of lunasin used in our study," Dr de Mejia remarked. "It certainly seems feasible to create a lunasin-enriched product that people could consume in a preventive way."

A new age of science delivers the formulas for youth at any age at 60%-70% off!

Fall Skin Care Sale 

It used to be that the best you could hope for was to age with grace. Times have certainly changed. It's no longer about aging well. It's about staying young. And there's a real science to that. We ought to know. We've been researching it for years. So why look your age. Just look for the answers. You'll find them right here at remarkable savings. Science-based formulas designed to sustain youth at any age.

RejuveneX® Factor
50 ml

Item #00918

$65.00
$26.00

Ultra RejuveNight®
2 ounces

Item #00676

$39.95
$15.98

European Leg Solution featuring Certified Diosmin 95
30 vegetarian tablets

Item #01042

$20.00
$8.00

Skin Restoring Ceramides with Lipowheat™
30 liquid capsules

Item #01502

$25.00
$10.00

DermaWhey
60 capsules

Item #01313

$65.00
$26.00

Lipowheat™ is a trademark of LAVIPHARM Group of Companies.
http://www.lef.org/SkinCare/

Highlight 

LuraLean® Caps
Special Propolmannan Particle Size
120 vegetarian capsules

Item #01470

add to cart

LuraLean® consists of propolmannan, a highly purified, natural dietary fiber patented in 33 countries. It comes from Amorphophallus japonica, a rare tuberous plant found only in the mountainous regions of northern Japan.

Propolmannan boasts the highest molecular weight of any water-soluble fiber in the natural world. Using cutting-edge technology, it has been reduced to a special particle size that maximizes density while remaining in desirable viscous form. A 500 mg capsule of propolmannan contains more fiber than the same milligram amount from other plants. Just as importantly, natural enzymes that would otherwise cause it to break down during digestion have been removed.

Butterbur Extract with Standardized Rosmarinic Acid
60 softgels

Item #00884
add to cart

Butterbur Extract with Standardized Rosmarinic Acid contains a patented butterbur extract. State-of-the-art technology allows for standardization of butterbur's key active ingredients while ensuring that the extract is free of any undesirable compounds, including pyrrolizidine alkaloids.

This formula also contains standardized rosmarinic acid, a plant polyphenol derived from rosemary leaf. Rosmarinic acid helps regulate inflammatory responder cells, thus providing effective, temporary relief while supporting healthy immune function and normal respiratory function. Luteolin, another plant flavonoid, has been shown to help maintain healthy DNA and support a healthy inflammatory process. Also included is perilla leaf extract.

shadow

Highlight 

Life Extension Update What's Hot
Omega-3 users are different Low folate and vitamin B12, elevated homocysteine predict cognitive decline
B vitamin supplements slow brain atrophy in cognitively impaired patients Optimal levels of folate and vitamin B12 needed for maintaining cognitive function
B12 may help prevent brain shrinkage    
       
Life Extension Magazine® Health Topics
Vitamin B12: the multiple benefits of this complex supplement Age related cognitive decline
Vitamin B12: surprising new findings Homocysteine Reduction
       
shadow