Whole Body Health Sale

Life Extension Update

How resveratrol helps combat breast cancer

How resveratrol helps combat breast cancer

Tuesday, October 11, 2011. The October 11, 2011 issue of the Federation of the American Societies for Experimental Biology (FASEB) Journal reports the finding of Italian and U.S. researchers of an ability for resveratrol to inhibit the growth-promoting effects of estrogen in breast cancer cells. Resveratrol occurs in red grapes and wine, and is believed to be one of the compounds responsible for the' health benefits associated with consuming these foods.

"An accumulation of data has shown that the anticancer properties of resveratrol are related to its ability to down-regulate NF-kB [nuclear factor kappa-beta] activation, to cause cell cycle arrest in the G1 phase, or to trigger apoptosis in a variety of cancer cell lines," write Sebastiano Andò of the Faculty of Pharmacy at the University of Calabria and his associates in their introduction to the article. "Recent data show induction of apoptosis [programmed cell death] by resveratrol through MAPK-mediated p53 activation. Also, resveratrol binds specifically to several peptides such as breast cancer-associated antigen, breast cancer resistance protein, death-associated transcription factor, and estrogen receptors and can exert either estrogenic or antiestrogenic effects depending on the concentration."

The team evaluated the effects of resveratrol in several estrogen-receptor-positive breast cancer cell lines, including cells that are resistant to treatment with the estrogen receptor antagonist drug tamoxifen. They observed a reduction in the proliferation of treated cells compared to cells that were not treated with resveratrol. Further experimentation revealed that resveratrol significantly lowered the cells' estrogen receptor levels in addition to acting via other mechanisms to inhibit their growth.

"Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy," stated Dr Andò.

Although FASEB Journal Editor-in-Chief Gerald Weissmann, MD, does not recommend that breast cancer patients drink wine in an attempt to treat their disease, he predicted that "Scientists haven't finished distilling the secrets of good health that have been hidden in natural products such as red wine."

shadow
What's Hot Highlight

Resveratrol shows preventive benefit against metabolic syndrome

Resveratrol shows preventive benefit against metabolic syndrome

The September, 2011 issue of Diabetes published the finding of researchers at the University of Alberta of a protective effect for resveratrol, a compound found in red grapes and other plant foods, against the development of metabolic syndrome, a group of symptoms that increase the risk of diabetes and cardiovascular disease.

Jason Dyck of the University of Alberta's departments of Pediatrics and Pharmacology and his colleagues exposed pregnant rats to a normal environment or one that was low in oxygen during the latter third of their gestational periods. (Oxygen deprivation can restrict fetal growth as well as increase the risk of metabolic syndrome later in life.) The animals' offspring were given high fat diets after weaning, and some were supplemented with resveratrol for nine weeks. Glucose tolerance, insulin resistance, abdominal fat, and triglyceride and free fatty acid levels were measured at the end of the treatment period in order to evaluate the development of metabolic syndrome.

While rats that were exposed to a hypoxic environment had more severe symptoms of metabolic syndrome compared to those that were exposed to a normal environment, animals that received resveratrol had less abdominal fat, better lipid levels, lower peripheral triglyceride levels, and improvements in insulin resistance and glucose tolerance compared to those that did not receive the compound.

"There is a concept that in utero, there are genetic shifts that are occurring – reprogramming is occurring because of this strenuous environment babies are in, that allows them to recover very quickly after birth," Dr Dyck explained. "When babies are growth-restricted, they usually have a catch-up period after they are born where they catch up to non-growth-restricted groups. It might be that reprogramming that creates this kind of 'thrifty' phenotype, where they want to consume and store and get caught up. That reprogramming appears to make them more vulnerable to developing a host of metabolic problems."

Fall Skin Care Sale Ends October 17!

Fall Skin Care Sale 

It used to be that the best you could hope for was to age with grace. Times have certainly changed. It's no longer about aging well. It's about staying young. And there's a real science to that. We ought to know. We've been researching it for years. So why look your age? Just look for the answers. You'll find them right here at remarkable savings. Science-based formulas designed to sustain youth at any age.

Beautiful Necessities Bundle
(Dry-Normal Skin)

(contains Cosmesis Hyaluronic Facial Moisturizer, TAL•SHI™ Foaming Facial Cleanser, Skin Restoring Ceramides with Lipowheat™ and free gift!)
Item #BNDNKIT

$123.80*
$38.09

Beautiful Necessities Bundle
(Oily Skin)

(contains Cosmesis Hyaluronic Oil-Free Facial Moisturizer, TAL•SHI™ Foaming Facial Cleanser, Skin Restoring Ceramides with Lipowheat™ and free gift!)
Item #BNOKIT

$123.80*
$38.09

RejuveneX® Factor 1.7 oz.
Item #00918

$65.00
$26.00

Ultra RejuveNight® 2 oz.
Item #00676

$39.95
$15.98

European Leg Solution
600 mg 30 vegetarian tablets

Item #01042

$20.00
$8.00

Skin Restoring Ceramides with Lipowheat™ 30 liquid capsules
Item #01502

$25.00
$10.00

* Includes value of free gift.
http://www.lef.org/SkinCare/

Highlight 

Enhanced FernBlock® with Sendara®
Item #01311

add to cart

Life Extension® offers an oral supplement to help protect against harmful solar radiation. During a decade of clinical trials, FernBlock® has shown remarkable effectiveness in shielding skin against dangerous ultraviolet exposure. Studies have shown that this fern extract has a high affinity for skin tissue and helps protect against ultraviolet damage shown to cause premature skin aging and wrinkling.

This product has been upgraded to contain Sendara®, a patented blend of the herbs ashwagandha and Indian gooseberry. It is rich in flavonoids and steroidal lactones called withanolides, which are thought to have a number of beneficial properties.

Bone Strength Formula with KoAct®
Item #01211
Featured Video

add to cart

The use of diets high in collagen to improve bone health dates back to ancient cultures. Now Life Extension brings you an exciting formulation with KoAct®, a patented chelated form of calcium and collagen designed to maintain optimal bone health. KoAct® helps maintain bone strength and mineral density. This remarkable ingredient allows for greater strength and flexibility, so your bones can absorb energy, reducing the risk of age-related injuries. Additional plant extracts from bamboo and dried plum have also been added for their bone-protective minerals and polyphenols.

If you need extra bone support, ask your healthcare professional how Bone Strength Formula with KoAct® can be part of a comprehensive nutritional program in conjunction with proper resistance exercise.

shadow

Highlight 

Life Extension Update What's Hot
Daily aspirin reduces estrogen receptor positive breast cancer risk How polyphenols inhibit prostate cancer growth
Resveratrol reduces prostate cancer growth in mice Resveratrol helps cancer cells overcome resistance to common drug
    Resveratrol may block first step in breast cancer development
       
Life Extension Magazine® Health Topics
New scientific options for preventing breast cancer: Research update on compounds to incorporate into your breast health program Breast cancer
Resveratrol: powerful protection against prostate cancer Complementary alternative cancer therapies
       
 

shadow 

Lipowheat™ is a trademark of LAVIPHARM Group of Companies.Patent Pending Sendara® is a registered trademark of NutraGenesis LLC. FernBlock® is a registered trademark of Industrial Farmaceutica Cantabria, S.A.