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Supplementing a low fat diet with fish oil reduces prostate cancer cell growth

Supplementing a low fat diet with fish oil reduces prostate cancer cell growth

Friday, October 28, 2011. In an article published online on October 25, 2011 in the journal Cancer Prevention Research, clinical professor of urology William Aronson of the University of California Los Angeles Jonsson Comprehensive Cancer Center and his associates report a benefit for a low fat diet supplemented with fish oil in retarding the growth of prostate cancer. Fish oil is high in the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid that help combat inflammation, which is a factor in many cancers.

The current trial enrolled prostate cancer patients scheduled for surgical removal of the prostate gland. Four to six weeks prior to surgery, the men were divided to receive a diet in which 15 percent of calories were provided by fat, supplemented with five grams of fish oil per day, or a high-fat Western diet.

Men who received the fish oil capsules had higher cell membrane levels of omega-3 fatty acids and reduced omega-6 fatty acids from corn oil at the end of the treatment period. Examination of the excised prostate glands found a reduced rate of cell proliferation in the fish oil-supplemented group as evidenced by staining with an antibody against a protein involved in cell growth known as Ki-67. Additionally, blood drawn from the treatment group reduced the growth of prostate cancer cells in vitro in comparison with blood obtained from men who did not receive fish oil. "The percentage of prostate cancer cells that stained for Ki-67 was determined by the pathologist, and this gave us an objective measurement of the percentage of cells that were actively dividing and therefore more aggressive," Dr Aronson explained. "Previous studies found that patients with higher levels of Ki-67 in their prostate cancer tissue were more likely to have their prostate cancer progress to advanced stages, and were more likely to die from their prostate cancer. Thus, we are extremely encouraged by our findings that a low-fat diet with fish oil lowered Ki-67 levels and may have the potential to slow the progression of prostate cancer."

"The finding that the low-fat, fish oil diet reduced the number of rapidly dividing cells in the prostate cancer tissue is important because the rate at which the cells are dividing can be predictive of future cancer progression," he noted. "The lower the rate of proliferation, the lesser the chances that the cancer will spread outside the prostate, where it is much harder to treat."

"The key to this study was having the meals prepared and delivered to the study participants," he added. "This resulted in a very high rate of compliance, making the study very well controlled."

"You truly are what you eat," Dr Aronson remarked. "Based on our animal studies, we were hopeful that we would see the same effects in humans. We are extremely pleased about our findings, which suggest that by altering the diet, we may favorably affect the biology of prostate cancer."

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Soy peptide aids in blocking metastasis

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An article published online on September 10, 2011 in the journal Cancer Letters describes the discovery of Elvira Gonzalez de Mejia and Vermont P. Dia of the University of Illinois in Urbana of a benefit for lunasin, a peptide that occurs in soy, in preventing the spread of colon cancer to the liver, the predominant site of metastasis for this type of cancer.  "When lunasin was used in combination with the chemotherapy drug oxaliplatin, we saw a sixfold reduction in the number of new tumor sites," revealed Dr de Mejia, who is an associate professor of food chemistry and food toxicology at UI.

The current study utilized mice bred to develop colon cancer that metastasizes to the liver.  The researchers divided the animals to receive daily injections of lunasin, lunasin plus the chemotherapy drug oxaliplatin, oxaliplatin alone or neither compound.  "The group that received lunasin alone had 50 percent fewer metastatic sites,” reported Dr de Mejia.  “But an even more exciting result was seen in the group that received both lunasin and the chemotherapy drug—only 5 new cancer sites when compared with 28 in the control group.”

"This huge reduction in metastasis was achieved with the amount of lunasin in only 25 daily grams of soy protein, the amount recommended in the FDA health claim," noted Dr Dia, who is a University of Illinois postdoctoral fellow.  "In this study, we have learned that lunasin can penetrate the cancer cell, cause cell death, and interact with at least one type of receptor in a cell that is ready to metastasize."

"Two glasses of soy milk a day generally provide half the amount of lunasin used in our study," Dr de Mejia remarked. "It certainly seems feasible to create a lunasin-enriched product that people could consume in a preventive way."

Life Extension Magazine® November, 2011 interactive version now live

Life Extension Magazine® November, 2011 interactive version now live

This e-issue of Life Extension Magazine® is extraordinarily easy to use, easy to navigate … with the same flip-the-page feeling you get from your printed copy, plus a few extra advantages. You can choose to search out a topic or keyword. Skim quickly. Skip ahead. Even order products. Now all that convenience is right at your fingertips.

Krill oil optimizes multimodel arthritis control, by Jason Ramirez
Conventional medicine's preferred treatments for arthritis fail to provide safe, long-term relief.

Reverse brain cell death by growing new mitochondria, by Michelle Flagg
Hundreds of published studies confirm mitochondrial decay as a primary cause of most neurodegenerative diseases.

The inflammatory factor underlying most cancers, by David Hoffnung
As many as 95% of all cancers utilize a molecule called nuclear factor-kappaB or NF-kB.

Age-defying Dara, by Jon Finkel
Swimming icon Dara Torres has won 12 Olympic medals in her career. Most impressive are the three silver medals she won in 2008 at the age of 41.

Topical resveratrol combats skin aging, by Robert Goldfaden and Gary Goldfaden, MD
Years of research confirm resveratrol's power to boost longevity when taken orally. Dermatologists are now discovering that when applied topically, resveratrol also protects against skin aging, with 17 times the antioxidant potency of the expensive anti-wrinkle drug idebenone.

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