Weight Loss Sale

Life Extension Update

Higher vitamin D levels associated with lower risk of deadly cancer

Higher vitamin D levels associated with lower risk of deadly cancer

Tuesday, November 29, 2011. In an article appearing online on November 15, 2011 in the journal Cancer Epidemiology, Biomarkers & Prevention, Brian M. Wolpin of Dana-Farber Cancer Institute and his colleagues report an association between higher circulating levels of vitamin D and a lower risk of pancreatic cancer among participants in five large prospective studies.

The current study included 451 subjects diagnosed with pancreatic cancer matched with two to three cancer-free controls, selected from participants in the Health Professionals Follow-Up Study, the Nurses' Health Study, the Physicians' Health Study, the Women's Health Initiative-Observational Study and the Women's Health Study. Average follow-up periods ranged from 14.1 to 25.3 years. Stored plasma samples collected upon enrollment in the studies were analyzed for 25-hydroxyvitamin D.

Vitamin D levels averaged 61.3 nanomoles per liter among participants diagnosed with pancreatic cancer and 64.5 nanomoles per liter in the control subjects. A declining risk of the disease was observed in association with rising levels of vitamin D. When participants whose vitamin D level was among the top one-fifth of subjects were compared with those in the lowest fifth, a 33 percent reduction in pancreatic cancer risk was observed. Adjustment for age and separate analysis of subgroups, including Caucasians, men, and women, resulted in a similar association.

When the risk of cancer of the pancreas was analyzed according to sufficient or insufficient vitamin D status, compared to those with insufficiency (defined as less than 50 nanomoles per liter) there was a 29 percent lower risk determined for those with sufficient levels of 75 nanomoles per liter or higher. In contrast with findings suggested by an earlier study, no increased risk was observed among men and women whose vitamin D levels were 100 nanomoles per liter or greater.

"Vitamin D and its analogues can slow proliferation of pancreatic cancer cells both in cell culture and in xenograft mouse models," the authors write. "Clinical studies are underway to exploit these effects of vitamin D and its analogues in patients with pancreatic cancer."

"In light of the high prevalence of vitamin D insufficiency in the population, further studies should examine whether increasing vitamin D levels impacts the incidence of this highly lethal malignancy," they conclude.

shadow
What's Hot Highlight

Vitamin D essential to combat TB

What's Hot

In an article published online on October 12, 2011 in Science Translational Medicine Dr Robert Modlin and his colleagues at the University of California, Los Angeles report an essential role for vitamin D in the body's ability to fight tuberculosis (TB).

The rate of infection for tuberculosis is highest in certain areas of Africa–a fact that may be due to a reduced ability to manufacture vitamin D among individuals with darker skin. In previous research conducted by the team, the vitamin was found to be involved in the production of cathelicidin, which aids the innate immune system's response to tuberculosis infection. In the current study, Dr Modlin and his colleagues discovered that it is necessary to have a sufficient amount of vitamin D in the body in order for white blood cells known as T-cells to release interferon-gamma, which directs infected immune cells to attack the tuberculosis bacteria. When the team subsequently tested the immune responses of blood samples obtained from humans with and without sufficient vitamin D levels, serum from those with vitamin D insufficiency failed to stimulate an immune response; however, the response was restored upon the addition of vitamin D.

"The role of interferon has been speculated for years in numerous studies, but previous research didn't take into account that sufficient vitamin D was needed to help interferon-gamma trigger an effective immune response," stated study coauthor Dr John Adams. "Now we understand better how this chain reaction works."

"Over the centuries, vitamin D has intrinsically been used to treat tuberculosis," noted first author Mario Fabri. "Sanatoriums dedicated to tuberculosis patients were traditionally placed in sunny locations that seemed to help patients -- but no one knew why this worked."

"Our findings suggest that increasing vitamin D levels through supplementation may improve the immune response to infections such as tuberculosis," he concluded.

Life Extension Magazine® December, 2011 Now Available in Electronic Format!

Life Extension Magazine® December, 2011 interactive version now live

 

Exclusive interview: Suzanne Somers uses novel stem cell therapy during breast rejuvenation, by William Faloon

Exclusive interview: cell-assisted lipotransfer breast restoration, by Greg Fahy

Cancer establishment hides radiation side effects, by William Faloon

Consumers do crave healthy foods! By William Faloon

Link between alcohol and cancer death, by Michelle Flagg

CR Way™ success stories: Real people who have changed their lives by altering their calorie intake, by Paul McGlothin and Meredith Averill

Outrageous FDA delay endangers melanoma victims, by Aimee Dingwell

Super Sale

Latest Supplements

Rich Rewards Breakfast Blend
Item #01609

add to cart

Not all coffee provides the same health-protective effects. When it comes to obtaining coffee's full range of benefits, most people aren't getting their money's worth. The reason? Most of the coffee bean's polyphenol content is destroyed during the roasting process required to create a dark, rich blend.

Among the most beneficial polyphenols is chlorogenic acid, a potent antioxidant polyphenol clinically proven to favorably modulate dangerous after-meal glucose surges and support blood sugar levels already within healthy range. Life Extension®'s new Rich Rewards Breakfast Blend is made using a patented, 100% natural process called HealthyRoast™. It delivers a more complete nutritional profile of the coffee bean, yielding chlorogenic acid levels far greater than other premium brands.

Rich Rewards Decaf Roast
Item #01610

add to cart

Handpicked deep in the rainforests of Central America, Rich Rewards consists exclusively of 100% certified USDA organic Arabica coffee beans, gently roasted in small batches and ground for easy brewing.

Have you given up coffee because it upsets your stomach? With Rich Rewards, you can enjoy coffee again. The HealthyRoast™ process preserves special, naturally occurring compounds in coffee that soothe your stomach.

Concerned about caffeine but don't like the weak taste of decaffeinated coffee? With Rich Rewards Decaffeinated Roast, you can limit your caffeine intake without compromising on flavor. The caffeine is removed through a completely chemical-free water process, which relies solely on water and carbon filters. It delivers the full flavor, aroma, and body of the Arabica bean.

shadow

Highlight

Life Extension Update What's Hot
Higher vitamin E levels in smokers linked with reduced pancreatic cancer risk Resveratrol inhibits pancreatic cancer stem cell properties
Vitamin D slashes pancreatic cancer risk Promising future predicted for resveratrol
Harvard study of professional men finds greater vitamin D levels protective against all cancers Vitamin B6 stops pancreatic cancer growth
       
Life Extension Magazine® Health Topics
Guarding against the dangers of vitamin D deficiency Pancreatic cancer
Vitamin D: cancer prevention and other new uses

Complementary alternative cancer therapies
       

shadow