Life Extension Final Clerance Sale

Life Extension Update

Reduced childhood vitamin D levels predict diabetes

Reduced childhood vitamin D levels predict diabetes

Friday, December 9, 2011. In an article appearing in the January, 2012 issue of the Journal of Clinical Endocrinology & Metabolism, Micah Olson, MD, of the University of Texas Southwestern Medical Center in Dallas and her associates report that children suffering from obesity and insulin resistance (which are both associated with diabetes) are more likely to have reduced serum levels of vitamin D in comparison with non-overweight children.

The current study evaluated serum 25-hydroxyvitamin D levels, fasting glucose and insulin levels, insulin resistance and other factors in 411 obese and 87 non-overweight children between the ages of six and sixteen residing in North Texas. Dietary information collected from the participants included daily intake of milk, soda, juice, fruit and vegetables, and whether or not the subject regularly ate breakfast.

While 68 percent of non-overweight participants had insufficient vitamin D levels of less than 75 nanomoles per liter (nmol/L) and 22 percent had deficient levels lower than 50, among obese children, the incidence of insufficiency and deficiency rose to 92 and 50 percent. Low vitamin D levels were associated with drinking more sodas and juice as well as with skipping breakfast. Among obese children, a significant relationship was observed between increased insulin resistance with lower vitamin D levels.

In their discussion of the findings, the authors note that "the difference in mean 25-hydroxyvitamin D levels between obese and non-overweight subjects was 18.5 nmol/L. Obese children would need to consume an extra 600 to 1200 IU (the equivalent of six to twelve 8-ounce cups of milk) of cholecalciferol daily to make up the difference in mean 25-hydroxyvitamin D levels seen in our study. Thus, poor dietary habits alone cannot explain the low 25-hydroxyvitamin D levels seen in obese children."

"Our study found that obese children with lower vitamin D levels had higher degrees of insulin resistance," stated Dr Olson, who is affiliated with Southwestern Medical Center's Department of Pediatrics. "Although our study cannot prove causation, it does suggest that low vitamin D levels may play a role in the development of type 2 diabetes."

"Poor dietary habits such as skipping breakfast and increased soda and juice intake were associated with the lower vitamin D levels seen in obese children," she added. "Future studies are needed to determine the clinical significance of lower vitamin D levels in obese children, the amount and duration of treatment necessary to replenish vitamin D levels in these children and whether treatment with vitamin D can improve primary clinical endpoints such as insulin resistance."

shadow
What's Hot Highlight

High dose vitamin D supplementation suggested for obese adolescents

What's Hot

In a presentation at the annual meeting of Experimental Biology, University of Missouri associate professor of nutrition and exercise physiology Catherine Peterson reported a benefit for a high dosage of vitamin D3 in adolescents suffering from obesity. Obese adolescents have been observed to be half as efficient as those who are nonobese in utilizing the vitamin, resulting in a higher incidence of deficiency.

For the current study, University of Missouri Adolescent Diabetes and Obesity clinic patients with vitamin D insufficiency or deficiency were randomized to receive 4,000 international units (IU) per day vitamin D3 or a placebo for six months, in addition to standard diabetes treatment. Serum 25-hydroxyvitamin D levels were re-evaluated at the end of the treatment period.

The researchers observed significantly higher vitamin D levels in subjects who received vitamin D compared to those who received the placebo. "Obese adolescents face an increased risk for deficiency because they tend to absorb vitamin D in their fat stores, which prevents it from being utilized in their blood," explained Dr Peterson, who is the director of undergraduate studies for the Department of Nutrition and Exercise Physiology at the University's College of Human Environmental Sciences. "We found that a daily dose of 4,000 IUs of vitamin D3, the maximum intake level set by the Institute of Medicine, is both safe and effective at improving vitamin D status in obese adolescents."

"If obese adolescents only consumed the recommended 600 IUs, they would be in trouble," she noted. "It takes 4,000 IUs to raise their vitamin D status within a sufficient range. This is much higher than the currently recommended daily amount for this age group. This indicates that physicians need to carefully evaluate the vitamin D status in their overweight and obese patients."

Super Sale: Online Instant Savings!

Super Sale:  Online Instant Savings!

Stock up and save on vitamins, minerals, hormones, nutritional and weight loss supplements, even skin care. Over 350 cutting-edge formulations, plus over 20 new Life Extension® products are all available to you right now at remarkable savings.

Watch for Super Sale Web Exclusives! Keep checking with us to see what instant savings are in store for you!

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ 50 mg, 100 softgels
Item #01425

$58.00
$35.78*

Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract 120 softgels
Item #01482

$32.00
$18.90*

Super Bio-Curcumin®
60 vegetarian capsules

Item #00407

$38.00
$23.63*

Vitamin D3 5,000 IU
60 capsules

Item #00713

$11.00
$6.68*

Krill Healthy Joint Formula
30 softgels

Item #01600

$32.00
$19.58*

*Price based on 4-bottle Super Sale member purchase

http://www.lef.org/SuperSale/

Super Sale

Latest Supplements

Liver Efficiency Formula
Item #01608

add to cart

New Liver Efficiency Formula features two state-of-the-art molecular energizers shown to promote healthy liver function at the cellular level.

Schisandra chinensis is an adaptogenic vine native to Asia with a half-century of research and nearly 400 published studies validating its system-wide benefits. Researchers have discovered that the lignans contained in Schisandra fruit specifically support healthy levels of glutathione—the liver's own antioxidant defense system. Schisandra's bioactive molecular compounds are readily absorbed in all segments of the intestine in rats. In animal studies, Schisandra has been shown to improve glutathione status dramatically in depleted liver cells.

Also contained in the new Liver Efficiency Formula is a proprietary melon-based compound rich in one of nature's most powerful antioxidants.

OptiZinc®
Item #00915

add to cart

Zinc is a mineral that stimulates the activity of approximately 300 enzymes, which are substances that promote biochemical reactions in your body. These reactions are essential for the formation of superoxide dismutase, one of the body's most important free radical scavengers. Zinc promotes immune function, taste sensitivity, protein and DNA synthesis, insulin production, reproductive organ development and sperm motility. Zinc also supports normal growth and development during pregnancy, childhood, and adolescence.

Age-related declines in immune function are associated with zinc deficiency, and the elderly represent a group that is vulnerable to mild zinc deficiency. Certain aspects of immune function in the elderly have been found to improve with zinc supplementation.

shadow

Highlight

Life Extension Update What's Hot
Low vitamin D levels associated with weight gain in young women Teens get a "D" in vitamin D
Lower vitamin D levels predict increased blood sugar and insulin resistance Meta-analysis finds children who are supplemented with vitamin D have a lower risk of developing diabetes
Inadequate vitamin D levels prevalent among "healthy" children Some teens vitamin D deficient
       
Life Extension Magazine® Health Topics
Vitamin D supports healthy blood sugar Diabetes
Vitamin D's crucial role in cardiovascular protection Obesity: strategies to fight a rising epidemic
       

shadow