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Omega-3 fatty acids reduce cardiovascular events in non-statin drug users

Omega-3 fatty acids reduce cardiovascular events in non-statin drug users

Tuesday, March 20, 2012. An article published on February 1, 2012 in advance of print in the European Heart Journal reports a favorable effect for low dose omega-3 fatty acids on the risk of cardiovascular events, including heart attack, cardiac arrest and stroke, in patients with a history of heart attack who did not use statin drugs.

The current study included 3,740 men and women using statin drugs and 413 non-users who participated in the Alpha Omega Trial, which tested the effects of 400 milligrams per day of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), 2 grams per day of the omega-3 fatty acid alpha-linolenic acid (ALA), EPA/DHA plus alpha-linolenic acid, or a placebo on the risk of major cardiovascular events in post-heart attack patients between the ages of 60 and 80 years. Participants were enrolled from 2002 through 2006 and were followed for an average of 41 months.

Over the follow-up period, 13 percent of statin users and 15 percent of non-statin users experienced a major cardiovascular event. While neither EPA/DHA and/or ALA reduced cardiovascular events compared to the placebo in those who used statins, among those who did not use the drugs, consuming all three omega-3 fatty acids was associated with less than half the rate of experiencing an event compared to placebo. In their introduction to the article, Daan Kromhout and colleagues note that, "Although adding omega-3 fatty acids to statin therapy leads to significant reductions in triglyceride levels, it has also been suggested that the use of guideline-concordant statin therapy dilutes the effects of omega-3 fatty acids such that no additional protective effect is observed. This hypothesis is supported by the reduction in cardiovascular events through either fatty fish or EPA–DHA in trials in which less than one-third of the participants were on statin therapy."

"The present study indicates that low-dose supplementation with omega-3 fatty acids might reduce the risk of major cardiovascular events in statin non-users with a history of myocardial infarction," the authors conclude. "These results contribute to the explanation of the inconsistent results on the effects of omega-3 fatty acids in secondary prevention trials."

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What's Hot Highlight

Eating red meat increases the risk of dying over up to 28 years of follow-up

What's Hot

An article published online on March 14, 2012 in the Archives of Internal Medicine reveals an association between red meat consumption and an increase in the risk of dying from cardiovascular disease, cancer, or any cause over a follow-up period of up to 28 years.

Harvard School of Public Health research fellow An Pan, PhD and colleagues analyzed data from 37,698 men enrolled in the Health Professionals Follow-Up Study and 83,644 participants in the Women's Health Study who were free of cancer or cardiovascular disease upon enrollment. Dietary questionnaires completed every four years provided information on the intake of red meat and other foods.

Over the studies' follow-up periods, 23,926 deaths occurred, including 5,910 from cardiovascular disease and 9,464 cancer deaths. Each daily serving of unprocessed red meat was associated with a 13 percent increased risk of dying of any cause, and each serving of processed red meat with a 20 percent greater risk. For cancer, each serving of unprocessed and processed meat increased the risk of dying by 10 and 16 percent and for cardiovascular disease, by 18 and 21 percent. However, replacing one serving of red meat with poultry, fish, nuts, legumes, low fat dairy products or whole grains lowered the risk of death. "We estimated that 9.3 percent in men and 7.6 percent in women of total deaths during follow-up could be prevented if all the participants consumed fewer than 0.5 servings per day of total red meat," the authors write.

In an invited commentary, Dean Ornish, MD, of the University of California, San Francisco remarked that "More than 75 percent of the $2.6 trillion in annual U.S. health care costs are from chronic disease. Eating less red meat is likely to reduce morbidity from these illnesses, thereby reducing health care costs."

Events
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Highlight

Life Extension Update What's Hot
Small increase in daily omega-3 results in large reduction in arrhythmia-related events and fatal heart attack risk in diabetic patients More omega-3 fatty acid intake better to prevent heart disease deaths
High omega-3 diet of Japanese linked with significantly lower heart disease risk compared to Americans Greater fish oil intake linked with lower fatal heart attack risk
Omega-3 fatty acids improve heart attack survival in rats Omega-3 fatty acids lower mortality and hospital admissions in heart failure patients
       
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Crominex®3+ is a registered trademark of Natreon, Inc. CinSulin® is a registered trademark of Tang-An Medical Ltd., manufactured under US patent #6,200,569. InSea2® is a registered trademark of innoVactiv™