Life Extension Final Clerance Sale

Life Extension Update

Consuming berries could delay brain aging up to two and a half years

Consuming berries could delay brain aging up to two and a half years

Friday, April 27, 2012. An article published online on April 26, 2012 in the Annals of Neurology reports a protective effect for diets containing high amounts of blueberries and strawberries against cognitive decline in older women. Berries are high in compounds known as flavonoids, which may help reduce the negative impact of inflammation and stress on cognitive function.

"As the U.S. population ages, understanding the health issues facing this group becomes increasingly important," commented lead researcher Elizabeth Devore of Brigham and Women's Hospital and Harvard Medical School. "Our study examined whether greater intake of berries could slow rates of cognitive decline."

Dr Devore and her associates evaluated data from women who were between the ages of 30 and 55 upon enrollment in the Nurses' Health Study in 1976. Dietary questionnaires completed every four years since 1980 were analyzed for the frequency of berry intake as well as the intake of 31 individual flavonoids representing six major flavonoid subclasses commonly found in US diets. Cognitive function was tested every two years in 16,010 participants who were over the age of 70 between 1995 and 2001.

Consuming a relatively high amount of blueberries or strawberries was associated with a slower decline in cognitive function test scores over the follow-up period compared to women whose intake was lower, resulting in a delay in cognitive aging of up to 2.5 years. Greater intake of the anthocyanidin class of flavonoids and total flavonoids was also associated with a reduced rate of decline.

"Substantial biologic evidence supports our finding that berry and flavonoid intake may be related to cognition," the authors write. "Berry-derived anthocyanidins are uniquely and specifically capable of both crossing the blood–brain barrier and localizing in brain regions involved in learning and memory (eg, the hippocampus). In multiple studies of rats, blueberry or strawberry supplementation significantly reduced age-related declines in neuronal signaling and cognitive behavior, and supplementation at older ages reversed neuronal and cognitive decline."

"We provide the first epidemiologic evidence that berries may slow progression of cognitive decline in elderly women," Dr Devore announced. "Our findings have significant public health implications as increasing berry intake is a fairly simple dietary modification to test cognition protection in older adults."

shadow
What's Hot Highlight

Berry brain benefit

What's Hot

A review published online on January 23, 2012 in the Journal of Agricultural and Food Chemistry describes a multitude of positive effects for berries on neurologic function. "A growing body of preclinical and clinical research has identified neurological benefits associated with the consumption of berry fruits," write Marshall G. Miller and Barbara Shukitt-Hale, PhD of Tufts University in their introduction to the article. "In addition to their now well-known antioxidant effects, dietary supplementation with berry fruits also has direct effects on the brain. Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function."

Berries have antioxidant effects, such as that demonstrated for mulberry in Parkinson's disease. Wolfberry, also called gogi berry, may have direct neuroprotective effects that are independent of its antioxidant benefits. In animal studies, blueberries have been associated with a variety of brain benefits, including a reduction in age-related increases in nuclear factor-kappa beta. Aged rats given blueberries, cranberries or blackberries have better balance and control, and a reduction in amyloid beta has been observed in association with blueberry intake in mice bred to develop specific aspects of Alzheimer's disease. In humans with mild cognitive impairment, daily consumption of blueberry juice resulted in improved word list recall and better performance in comparison with subjects who receive a placebo.

"Given that neurodegeneration and cognitive decline are chronic processes, throughout adulthood, future research should also identify critical periods during which increased consumption of berry fruits is most effective and the extent to which berry fruits prevent or even reverse the deleterious effects of aging," the authors conclude. "Furthermore, the optimal dietary intake, necessary duration of supplementation, and longevity of the effects following the cessation of supplementation should also be explored."

Overstock Blowout Sale—Save 60%-75%!

Overstock Blowout Sale—Save 60%-75!

Life Extension® continues to enhance its formulations at a record-breaking pace. To make room for newer versions, we've slashed prices on advanced nutrient formulas that commercial companies still have not caught up with! This is your chance to buy these premium-quality Life Extension supplements at savings up to 75%. All made with the finest ingredients. All manufactured to the highest standards.

Super Ubiquinol CoQ10 100 mg, 60 softgels
Item #01226

$56.00
$22.40

Mega EPA/DHA 360 mg EPA/240 mg DHA, 120 softgels
Item #00625

$19.95
$6.98

Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean®† 60 vegetarian capsules
Item #01509

$39.00
$13.65

Calorie Control Weight Management Formula† 14.18 ounces powder
Item #01493

$50.00
$17.50

CoffeeGenic™ Green Coffee Extract 200 mg, 90 vegetarian capsules
Item #01604

$25.00
$8.75

Specially-Coated Bromelain 500 mg, 60 enteric-coated tablets
Item #01203

$21.00
$8.40

†This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
http://www.lef.org/overstock/

Latest Supplements

Sun Protection Spray with Beta-Glucan (SPF 30)
Item #00971

add to cart

Sun Protection Spray contains a blend of sunscreens that provide extensive protection against UVA and UVB light. The ingredient octinoxate (or octyl methoxycinnamate) is an FDA-rated Category I sunscreen that offers outstanding protection against UVB waves. Studies have shown that octinoxate not only protects against sunburn, but even defends you below the skin line against UV light-induced trauma. Avobenzone, an oil-soluble ingredient, has a unique ability to absorb a much wider range of ultraviolet light including UVA and UVB wavelengths. Sun Protection Spray also features vitamins C and E as protection against free radicals and to nourish healthy collagen, while NaPCA helps skin regain its youthful softness. The inclusion of beta glucan improves the outward signs of aging for healthier, younger-looking skin.

Enhanced Natural Sleep® with Dual-Action Melatonin
Item #01507

add to cart

Enhanced Natural Sleep® with Dual-Action Melatonin helps promote optimal sleep and youthful appearance. It contains these three clinically validated, natural compounds shown to support healthy, restful sleep, promote healthy response to stress, and target sleep debt-related factors associated with skin aging:

  1. Bioactive milk peptides (Lactium®) are a cutting-edge nutrient complex consisting of patented bioactive peptides found naturally in milk. Used widely in Europe to promote sustained and restful sleep patterns, published studies reveal that these bioactive milk peptides also promote relaxation, help with stress, and support daytime cognition.
  2. Melatonin (very low dose). A compound produced in the brain to regulate the sleep-wake cycle, melatonin levels naturally decline with age, which can adversely affect sleep patterns in many people. In both immediate and time-release form, melatonin has been shown to support sustained and restful sleep.
  3. Sendara® is a proprietary nutrient complex consisting of ashwagandha and Indian gooseberry extracts.
shadow

Highlight

Life Extension Update What's Hot
Consuming more flavonoid-rich foods could offer protection against Parkinson's Berries benefit blood pressure
Grapes and berries may help protect the brain Grapes and berries may help protect the brain
Blueberry juice enhances memory in older adults Prevention of "normal" brain aging
       
Life Extension Magazine® Health Topics
Age related cognitive decline Atherosclerosis and cardiovascular disease
Blueberries: colorful protection for a healthier heart, sharper brain, and cancer defense Chronic inflammation
The disease-fighting power of berries    
       

shadow