Life Extension Blood Test Super Sale

Life Extension Update

CoQ10 shows promise for Huntington's disease

CoQ10 shows promise for Huntington's disease

Friday, June 22, 2012. Research conducted by Kevin M. Biglan, MD, MPH of the University of Rochester and his colleagues, described in the inaugural issue of the Journal of Huntington's Disease, provides more evidence for the use of coenzyme Q10 (CoQ10) to retard Huntington disease's progression. Huntington's disease is a neurodegenerative disorder caused by a genetic error that produces abnormal proteins in the brain's cells. Scientists believe that these protein deposits result in oxidative stress that ultimately kills the cells that contain them.

CoQ10, due to its support of the cells' mitochondria and its antioxidant effect, has been investigated as a possible agent to treat Huntington's disease. The current research evaluated 14 Huntington's disease patients and 6 healthy controls that had been given CoQ10 in a clinical trial known as Pre-2Care. Participants in Pre-2Care received 1200 milligrams CoQ10 daily for eight weeks and 3600 milligrams per day for the remaining 12 weeks of the study.

Stored blood samples obtained at the beginning and end of the treatment period were analyzed for serum 8-hydroxy-2'-deoxyguanosine (8OHdG), which has been correlated with the presence of oxidative stress in the brain's cells and has been found to be elevated in those with Huntington's disease and other neurologic disorders. While the Pre-2Care study had found a reduction in Huntington's disease symptoms after treatment with CoQ10, the current research uncovered a 20 percent reduction in 8OHdG levels in CoQ10-treated Huntington's disease patients as well as a nonsignificant reduction in subjects who did not have the disease. "Identifying treatments that slow the progression or delay the onset of Huntington's disease is a major focus of the medical community," observed Dr Biglan, who is a neurologist at the University of Rochester Medical Center. "This study demonstrates that 8OHdG could be an ideal marker to identify the presence oxidative injury and whether or not treatment is having an impact."

He noted that "While the current data can't address the use of 8OHdG as a surrogate marker for the clinical effectiveness of antioxidants in Huntington's disease, we've established that 8OHdG can serve as a marker of the pharmacological activity of an intervention."

"This study supports the hypothesis that CoQ exerts antioxidant effects in patients with Huntington's disease and therefore is a treatment that warrants further study," he concluded. "As importantly, it has provided us with a new method to evaluate the efficacy of potential new treatments."

shadow
What's Hot Highlight

Berry brain benefit

What's Hot

A review published online on January 23, 2012 in the Journal of Agricultural and Food Chemistry describes a multitude of positive effects for berries on neurologic function. "A growing body of preclinical and clinical research has identified neurological benefits associated with the consumption of berry fruits," write Marshall G. Miller and Barbara Shukitt-Hale, PhD of Tufts University in their introduction to the article. "In addition to their now well-known antioxidant effects, dietary supplementation with berry fruits also has direct effects on the brain. Intake of these fruits may help to prevent age-related neurodegeneration and resulting changes in cognitive and motor function."

Berries have antioxidant effects, such as that demonstrated for mulberry in Parkinson's disease. Wolfberry, also called gogi berry, may have direct neuroprotective effects that are independent of its antioxidant benefits. In animal studies, blueberries have been associated with a variety of brain benefits, including a reduction in age-related increases in nuclear factor-kappa beta. Aged rats given blueberries, cranberries or blackberries have better balance and control, and a reduction in amyloid beta has been observed in association with blueberry intake in mice bred to develop specific aspects of Alzheimer's disease. In humans with mild cognitive impairment, daily consumption of blueberry juice resulted in improved word list recall and better performance in comparison with subjects who receive a placebo.

"Given that neurodegeneration and cognitive decline are chronic processes, throughout adulthood, future research should also identify critical periods during which increased consumption of berry fruits is most effective and the extent to which berry fruits prevent or even reverse the deleterious effects of aging," the authors conclude. "Furthermore, the optimal dietary intake, necessary duration of supplementation, and longevity of the effects following the cessation of supplementation should also be explored."

Shop Life Extension's Weight Loss Sale

Overstock Blowout Sale—Save 60%-75!

Get the edge you need to succeed! Enjoy up to a 65% savings on our most popular weight management products. But hurry, this offer ends July 30, 2012.

Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean®, 60 vegetarian capsules
Item #01509

$39.00
$13.65

Anti-Adipocyte Formula with AdipoStat, 60 vegetarian capsules
Item #01510

$35.00
$12.25

Calorie Control Weight Management Formula with CoffeeGenic™ Green Coffee Extract, box of 60 stick packs
Item #01694

$64.00
$25.60

Calorie Control Weight Management Formula with CoffeeGenic™ Green Coffee Extract, 14.6 ounces powder
Item #01693

$60.00
$24.00

LuraLean® Caps, Special Propolmannan Particle Size, 120 vegetarian capsules
Item #01470

$28.00
$11.20

http://www.lef.org/lpages/weightloss/

These supplements should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Latest Supplements

Advanced Lipid Control
Item #01308
Featured Video

add to cart

For those who want to maintain healthful levels of lipids in the blood, Advanced Lipid Control contains two powerful nutrients that help protect key aspects of cardiovascular function.

Advanced Lipid Control contains theaflavins, which scientists have discovered provide multiple benefits for arterial health.

The second ingredient in Advanced Lipid Control is called AmlaMax®, a patent-pending extract of Indian gooseberry.

Hi-Lignan® NutriFlax®, 16 ounces
Item #00873

add to cart

Lignans are natural phytochemicals. Scientific research has shown lignans to have numerous health benefits for men and women:

  • High in dietary fiber, containing both soluble and insoluble fiber
  • Good source of plant-derived omega-3 fatty acids
  • Very low sodium content
  • Potassium to sodium ratio of 17:1
  • Preserves nature's balance of electrolytes
shadow

Highlight

Life Extension Update What's Hot
Melatonin prolongs life in animal model of Huntington's disease Fisetin shows promise in Huntington's disease experiments
High dose CoQ10 safe and well tolerated Longevity-linked pathway studied
CoQ10 and vitamin E combo improve learning in old animals Review finds CoQ10 safe and well tolerated by patients with neurodegenerative diseases
       
Life Extension Magazine® Health Topics
Has your CoQ10 become obsolete? Parkinson's disease
CoQ10's "other" health benefits Prevention protocols
How CoQ10 protects brain cells    
       

shadow

Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. AdipoStat is a proprietary ingredient derived from natural plant extracts exclusively distributed by InterHealth N.I. LuraLean® is a registered trademark of AHD International LLC. AmlaMax® is a registered trademark of DolCas Biotech, LLC. and is protected by U.S. patent No. 7,780,996.