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Life Extension® supports nutritional research in chronic kidney disease

Life Extension supports nutritional research in chronic kidney disease

Tuesday, July 17, 2012. In a study supported by Life Extension, recognized by the National Kidney Foundation, and published in Journal of Renal Nutrition, researchers at Baylor University in Texas evaluated the effects of fish oil ingestion in thirty-one patients with chronic kidney disease (CKD).

An important consideration in chronic kidney disease, a leading cause of disability in the United States, is excess production of proinflammatory factors called cytokines. These inflammatory factors are implicated in a variety of health conditions, including cardiovascular and joint health, as well as kidney health. Although numerous studies support the health benefits of the omega-3 fatty acids EPA and DHA found naturally in fish oil, the potential effects of supplementation with fish oil in chronic kidney disease have not been well characterized in the scientific literature.

The Baylor scientists conducted a double-blind, randomized, placebo-controlled trial in non-dialysis chronic kidney disease patients to evaluate a nutritional supplement vs. placebo upon a variety of proinflammatory parameters. The cytokines evaluated in the study included interleukin 1b (IL-1b) and interleukin 6 (IL-6). The active treatment group received fish oil containing 1,400 mg of EPA and 1,000 mg of DHA daily, along with olive fruit extract (600 mg daily), and sesame lignans (20 mg daily).

The researchers discovered that fish oil, olive fruit extract, and sesame lignans had a significant, beneficial effect upon the inflammatory cytokine IL-1b compared with placebo, with lower levels in the active treatment group. Interleukin-6 levels did not change significantly in chronic kidney disease patients during the short trial.

Future research to include larger numbers of patients as well as longer duration trials will help clarify the effects of nutritional supplementation upon inflammatory factors in chronic kidney disease over time.

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Vitamin B6 deficiency associated with inflammation

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In a study described online on May 23, 2012 in the Journal of Nutrition, researchers at Tufts University in Boston report a relationship between low levels of plasma pyridoxal-5'-phosphate (PLP), which indicate reduced levels of vitamin B6, with an increase in markers of inflammation.

"Low vitamin B6 status, based on plasma concentrations of pyridoxal-5-phosphate, has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes," write Lydia Sakakeeny of Tufts Jean Mayer USDA Human Nutrition Research Center and her colleagues. "Our objective was to examine the association between plasma PLP and multiple markers of inflammation in a community based cohort."

The current study included 2229 men and women enrolled in the Framingham Offspring study, who were recruited in 1971 and have undergone periodic examinations thereafter. Blood drawn between 1998 and 2001 was analyzed for plasma PLP and 13 markers of inflammation, including C-reactive protein, fibrinogen, interluekin-6, tumor necrosis factor-alpha and other factors.

The researchers created inflammation scores based on the values of each inflammatory marker. An inverse relationship was observed between high inflammation scores and low levels of PLP. The authors note that decreased plasma PLP levels may reflect mobilization of PLP into inflammatory sites and that a causative relationship between reduced vitamin B6 levels and inflammation cannot be determined. However, they conclude that "This study in combination with past findings further supports our hypothesis that inflammation is associated with a functional deficiency of vitamin B6."

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