Fall Skin Care Sale

Life Extension Update

Vitamin D supplementation cuts childhood colds and flu in half

Vitamin D supplementation cuts childhood colds and flu in half

Tuesday, August 28, 2012. A report published online on August 20, 2012 in the journal Pediatrics reveals a dramatic decrease in the incidence of wintertime acute respiratory tract infections (ARIs) in children supplemented with vitamin D. Although observational studies have associated a lower risk of the infections with higher vitamin D levels, the investigation is one of the first randomized, double-blinded trials to study the effects of vitamin D supplementation on childhood ARI.

The trial included 247 children residing in Mongolia, which receives limited winter sunlight. Participants had a median serum 25-hydroxyvitamin D concentration of 7 nanograms per milliliter (ng/mL) at the beginning of the study (a deficient level associated with reduced sunlight exposure). One hundred forty-three children received milk fortified with 300 international units (IU) vitamin D per day and 104 subjects received unfortified milk for seven weeks beginning in late January.

At the trial's conclusion, vitamin D levels increased to a median of 19 ng/mL among those who received vitamin D fortified milk while remaining the same among the control group. Parents of subjects who received vitamin D reported 48 percent fewer respiratory infections in their children over the course of the study compared with those whose children did not receive the vitamin. Adjustment for age and other factors resulted in a similar, 50 percent lower risk in the supplemented group.

"Our randomized controlled trial shows that vitamin D has important effects on infection risk," stated first author and Harvard Medical School professor of Medicine Carlos Camargo, MD. "In almost 250 children with low blood levels of vitamin D during winter, we found that taking a daily vitamin D supplement cut in half the risk of a respiratory infection."

"Our study design provides strong evidence that the association between low vitamin D and respiratory infections is causal and that treating low vitamin D levels in children with an inexpensive and safe supplement will prevent some respiratory infections," he added. "The large benefit was undoubtedly related to the low baseline vitamin D levels of these children, so I would not expect the supplement to provide similar benefit in children who start with healthy levels of vitamin D. The key question for future research is at what initial vitamin D level would children no longer receive benefit from winter supplementation?"

"At the time the trial was designed, the Institute of Medicine recommended 200 IU daily for all individuals from birth to age 50 years," the authors write. "The 2011 Institute of Medicine report has since increased the recommendation to 400 IU daily for children. Although this higher dose is certainly an improvement, we suspect that even 400 IU daily will fall short for many children with vitamin D deficiency. Other groups, such as the Canadian Paediatric Society, recommend 1000 IU daily for children, and we believe that this higher dose is more likely to achieve adequate 25-hydroxyvitamin D levels for almost all children without pushing them to a potentially toxic level."

shadow
What's Hot Highlight

Immune function impairment correlated with reduced vitamin D levels

What's Hot

In the May, 2012 issue of the Journal of Leukocyte Biology, Spanish researchers describe impairments in immune function in association with reduced levels of vitamin D.

Victor Manuel Martinez-Taboada, MD and his associates at the Unversidad de Cantabria, in Santander, Spain measured serum 25-hydroxyvitamin D levels in subjects aged 20 to 30, 31 to 59 and 60 to 86 years. They observed an age-related decline in serum vitamin D, with 5% of young, 21.7% of middle aged and 31.6% of the elderly subjects having levels less than 20 nanograms per milliliter, which was the level considered normal by the researchers. This led to the evaluation of vitamin D's relationship with toll-like receptor expression on white blood cells known as lymphocytes and monocytes. Toll-like receptors are proteins involved in innate immune system function that alert the immune system to microbial infections. The researchers discovered that the toll-like receptor that was impacted the most by insufficient vitamin D levels is toll-like receptor 7 (TLR7), which regulates the immune response to viruses.

"There are numerous studies showing the benefits of maintaining adequate vitamin D levels," commented Dr Martinez-Taboada. "As more and more research into vitamin D is conducted, we are learning that it is extremely important for human health. Our study is no different, and vitamin D supplements should be considered one of many tools that might help when conventional therapies are not enough."

"This study shows that sunlight, or more precisely the lack of vitamin D, could have a role in the seasonally higher rates of infection," commented John Wherry, PhD, who is the Journal of Leukocyte Biology's deputy editor. "More extensive studies must be conducted for this link to be conclusive, but since vitamin D supplements are inexpensive and generally safe, this is a really exciting discovery."

Final Clearance Sale of the Year
Save up to 75% on Premium Quality Supplements

Final Clearance Sale of the Year

This is your last chance to buy these remarkable supplements at dramatically discounted prices. Take advantage of this Final Clearance Sale to get incredible deals on top-quality products. But order soon, this sale ends September 17, 2012, or while supplies last. Call toll-free 1-866-606-9806 or simply order online!

If you're a resident of South Florida, you can visit the Life Extension Nutrition Center, conveniently located one mile north of Commercial Boulevard on the east side of US-1.

Advanced Natural Sex for Women®, 60 vegetarian capsules
Item #01627

$42.00
$16.80

GH Pituitary Support Day Formula, 120 vegetarian tablets
Item #01301

$48.00
$19.20

GH Pituitary Support Night Formula, 120 vegetarian capsules
Item #01302

$25.00
$10.00

Rosmarinic Acid Extract,
60 vegetarian capsules

Item #00917

$59.00
$23.60

Water-Soluble Pumpkin Seed Extract with Soy Isoflavones,
60 vegetarian capsules

Item #01210

$22.00
$7.70

http://www.lef.org/lpages/finalclearance/

Latest Supplements

Super K with Advanced K2 Complex

Omega-3 Tropical Whirl, 16 oz
Item #01633

add to cart

For decades, companies have sent samples of liquid fish oil supplements to Life Extension® that claimed to taste good. These were all rejected because they either tasted bad or had an unpleasant aftertaste. Finally a method has been developed to make a sugar-free liquid fish oil that tastes great, and has no unpleasant aftertaste.

An abundance of scientific research suggests wide ranging health dividends from the omega-3 fatty acids found in fish oil. Unfortunately, the typical Western diet is still disproportionately high in the omega-6 family of fatty acids and low in healthy omega-3 fatty acids.

For Life Extension® members who want another way to obtain the rich benefits of fish oils, there is now pleasantly natural flavored, easy to use, liquid omega-3 fish oil.

Pyridoxal 5'-phosphate capsules

Omega-3 Lemon Whirl, 16 oz
Item #01632

add to cart

Decades of research and over 15,000 studies confirm the vital importance of the omega-3 fatty acids known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Life Extension® members already know that the EPA and DHA found in fish oil provide substantial support for normal heart and brain health. But research has increasingly shown that the health-promoting effects of EPA and DHA may extend to an even larger range of benefits.

Life Extension® Omega-3 Highly Refined Fish Oil is a premium fish oil derived from sustainable small-species fish sources (anchovy, sardine and/or mackerel) harvested from the deep cold waters of Chile. Through careful molecular distillation and gentle processing, this fish oil is tested and found extremely low levels of environmental pollutants and safe for everyone in the family. These sensationally-flavored liquid fish oils are available in natural lemon or piña colada flavors.

shadow

Highlight

Life Extension Update What's Hot
Review concludes effectiveness for zinc supplements against common cold Vitamin D essential to combat TB
Lower vitamin D levels associated with common cold Vitamin D has long been essential to primate immune function
Probiotic plus vitamin/mineral supplement reduces upper respiratory tract infection incidence and symptoms Vitamin D is activated in the lungs to fight infection
       
Life Extension Magazine® Health Topics
Are you getting optimal flu prevention? The common cold
Unraveling a centuries-old mystery Influenza
What to do if you contract influenza including H1N1 (swine) flu or the common cold Bacterial infections
       

shadow