On August 30, 2012, the journal Arteriosclerosis, Thrombosis and Vascular Biology reported a protective effect for higher vitamin D levels against the risk of cardiovascular disease, heart attack and death from any cause over up to 29 years of follow-up.
Børge Nordestgaard of the University of Copenhagen and his associates evaluated data from 4,410 men and 5,709 women enrolled in the Copenhagen City Heart Study whose plasma 25-hydroxyvitamin D levels were measured between 1981 and 1983. The subjects were followed up to the present, during which 3,100 ischemic heart disease events, 1,625 heart attacks and 6,747 deaths occurred.
Participants whose vitamin D levels were among the lowest 5% at less than 15 nanomoles per liter were compared with those whose levels were among the top 50% at over 50 nanomoles per liter. "We have now examined the association between a low level of vitamin D and ischemic heart disease and death in the largest study to date," announced first author Peter Brøndum-Jacobsen. "We observed that low levels of vitamin D compared to optimal levels are linked to 40% higher risk of ischemic heart disease, 64% higher risk of heart attack, 57% higher risk of early death, and to no less than 81% higher risk of death from heart disease."
"With this type of population study, we are unable to say anything definitive about a possible causal relationship," Dr Nordestgaard noted. "But we can ascertain that there is a strong statistical correlation between a low level of vitamin D and high risk of heart disease and early death. The explanation may be that a low level of vitamin D directly leads to heart disease and death. However, it is also possible that vitamin deficiency is a marker for poor health generally."
"Our study suggests an inverse association between long-chain dietary omega-3 fatty acids EPA and DHA and fish oil supplement use with risk of endometrial cancer," the authors conclude. "Future studies should further explore associations with intake of specific fatty acids, food sources, and blood and tissue biomarkers to understand better the associations between these fatty acids and endometrial cancer risk."
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Epigenetics for breast cancer prevention, by Alexander Johnson
The science of epigenetics uses nutrients and certain drugs to regulate genes, thereby changing the way breast cancer cells age and reproduce.
Innovative laser therapy offers new hope for breast cancer patients, by Logan Bromwell
In a human clinical research trial supported by Life Extension®, scientists are testing an innovative, laser-assisted immune therapy against advanced breast cancer.
Dorothy Hamill: An inspiration on and off the ice, by Jon Finkel
Five years ago, America's Sweetheart—Olympic Gold Medal winner and longtime Ice Capades star, Dorothy Hamill─was diagnosed with breast cancer.
DHA: An essential brain food, by Kirk Stokel
Studies show that brain tissue contains the highest concentration of DHA in the body.
How bioflavonoids create youthful skin tone, by Gary Goldfaden, MD and Robert Goldfaden
A topical formulation harnesses the rejuvenating synergy of three flavonoids—quercetin, hesperidin, and rutin—to nourish and heal skin cells through multiple pathways.