Fall Skin Care Sale

Life Extension Update

Study finds no association between calcium intake and arterial calcification

Study finds no association between calcium intake and arterial calcification

Tuesday, November 13, 2012. Research described in a report published online on November 7, 2012 in the American Journal of Clinical Nutrition failed to establish a relationship between greater calcium intake and increased calcification of the coronary artery, a condition that characterizes heart disease. The finding contradicts the conclusions of a recent, widely publicized study, which suggested that calcium supplements might increase heart attack risk.

American researchers analyzed data from 588 men and 690 women between the ages of 36 and 83 years enrolled in the Framingham Offspring Study, which includes children and spouses of participants in the Framingham Heart Study. Responses to questionnaires completed between 1998 and 2001 were analyzed for calcium intake from food and supplements. Computed tomography (CT) scans conducted between 2002 and 2005 evaluated coronary artery calcification, an indication of calcified plaque in the heart's arteries.

Participants' calcium intake ranged from 8 milligrams to 3,050 milligrams per day. Twenty-five percent of the men and 65 percent of the women in the study reported using calcium supplements. Adjusted analysis of the data failed to find a significant association between total calcium intake and coronary artery calcium scores. Similar findings were obtained in separate analyses of calcium supplements and calcium from food.

The authors note that the Institute of Medicine recently concluded that evidence from clinical trials currently does not support an effect of calcium intake on cardiovascular disease risk. "Although the discussion of methodologic issues of studies that reported an adverse effect of calcium supplements on cardiovascular events has been presented elsewhere, some concerns include a lack of adjudicated endpoints, the undermining of random assignment, a low compliance with calcium supplements, and inadequate access to patient-level data" they write.

"This study addresses a critical question about the association between calcium intake and a clinically measurable indicator of atherosclerosis in older adults," stated lead author Elizabeth Samelson, PhD, who is an associate scientist at the Institute for Aging Research in Boston and an assistant professor at Harvard Medical School. "There was no increased risk of calcified arteries with higher amounts of calcium intake from food or supplements."

Nevertheless, she added that, "it is critically important that each individual discuss with a health care provider whether the recommendations are appropriate given his or her personal medical history."

shadow
What's Hot Highlight

Women lacking calcium at risk of primary hyperparathyroidism

What's Hot

October 19, 2012, the British Medical Journal reported the finding of researchers at Brigham and Women's Hospital of a protective effect for calcium from diet and supplements against primary hyperparathyroidism, a condition in which overactive parathyroid glands secrete too much parathyroid hormone, which can result in bone weakness and fractures.

The current study evaluated data from 58,354 nurses who were between the ages of 39 and 66 years upon enrollment in the Nurses' Health Study I in 1986. Responses to dietary questionnaires completed after enrollment were evaluated for the intake of calcium from diet and supplements. Over a 22 year follow-up period, 277 cases of primary hyperparathyroidism were diagnosed.

Women whose dietary calcium was among the top one-fifth of participants had a 44 percent lower adjusted risk of developing primary hyperparathyroidism compared to those whose intake was among the lowest fifth. When the intake of calcium from supplements containing more than 500 milligrams per day was analyzed, the risk of primary hyperparathyroidism was 31 percent less among those who supplemented in comparison with those who did not use calcium supplements.

"To our knowledge, we report results from the first prospective study of the relation between calcium intake and risk of primary hyperparathyroidism," Julie M. Paik and her colleagues announced. "In women, increased dietary and supplemental calcium intake was associated with a reduced risk for developing primary hyperparathyroidism, independent of age, body size, diet, and other factors."

In an accompanying commentary, James Norman of the Norman Parathyroid Center concludes that "Paik and colleagues' study provides evidence to support physicians in confidently encouraging female patients to take calcium supplements. Daily calcium supplements in modest doses are likely to provide more benefits than risks given that even mild primary hyperparathyroidism has important clinical associations and, over many years, even a moderate increase in calcium concentration probably helps reduce the incidence of parathyroid tumors."

Annual Super Sale on Now!

Annual Super Sale on Now!

Get these breakthrough products to help you stay younger and healthier longer. Stock up on all the health essentials you need all year. And while you're at it, share the health with gifts for those you love.

Below are just a few examples of the maximum savings you can receive during Life Extension's Annual Super Sale:

PQQ Caps with BioPQQ™ 10 mg, 30 vegetarian capsules
Item #01500

$24.00
$14.85*

Krill Healthy Joint Formula, 30 softgels
Item #01600

$32.00
$19.58*

Two-Per-Day Tablets, 120 tablets
Item #01715

$20.00
$12.15*

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, 100 mg, 60 softgels
Item #01426

$62.00
$35.10*

Super Omega-3 EPA/DHA with Sesame Lignans and Olive Fruit Extract, 120 softgels
Item #01482

$32.00
$16.81*

Cognitex® without Pregnenolone with Neuroprotection Complex, 90 softgels
Item #01696

$72.00
$41.85*

*Price based on super sale member volume purchase.

http://www.lef.org/SuperSale/

Latest Supplements

Optimized Quercetin

Extraordinary Enzymes, 60 capsules
Item #01706

add to cart

Human studies suggest that supplementary enzymes may improve digestion and help minimize post-meal glucose surges. Since proteins, plant fibers, and fats are broken down differently, one needs the proper spectrum of enzymes for optimal digestion. A new multienzyme formula facilitates both optimal nutrient absorption and broad relief from digestive discomforts without promoting after-meal glucose surges.

Extraordinary Enzymes provides a potent array of protease, cellulase, and lipase enzymes specially formulated to adapt to a variety of stomach acid pH conditions and powerfully support digestion. With a total of twelve different enzymes, this unique formula supports the digestion of just about any food that may pose a problem for you—whether a protein, fiber, or fat. Extraordinary Enzymes provides a blend of powerful enzymes to help your system convert a variety of foods to energy and readily absorb the nutrients in the foods you consume. This formulation may enhance protein content in your body and allow for better fat utilization.

 

Kyolic® Garlic Formula 102

Rich Rewards™ Lentil Vegetable Soup
Item #01705

add to cart

Life Extension® has formulated a lentil vegetable soup suitable for vegans that contains only garden-fresh ingredients, including lentils, mushrooms, tomatoes, carrots, extra-virgin olive oil, and a host of other beneficial plant foods.

Each serving of Rich Rewards Lentil Vegetable soup contains only 120 calories of the best-documented foods to maintain your precious health. You can consume the entire contents or use a smaller portion of the soup as part of a meal for you (or several people). The entire container supplies about 3.5 servings of these lentils, mushrooms, and vegetables — with none of the glucose-spiking fillers found in commercial soups. Rich Rewards Lentil Vegetable Soup is packaged in a re-closable bottle free of BPA. While the FDA says the BPA lining in most cans is safe, we at Life Extension have always used BPA-free containers.

shadow

Highlight

Life Extension Update What's Hot
Supplementing with calcium and vitamin D associated with lower risk of dying over three year period Without fortification and supplementation of some nutrients, many Americans would not meet recommended intake
Insufficient calcium may link hypertension, osteoporosis Vitamin K supplementation slows coronary artery calcification
Calcium supplements don't work if you don't take them Improved mineral intake could significantly reduce major heart disease risk factor
       
Life Extension Magazine® Health Topics
Flawed analysis misleads public about calcium and heart attack risk Atherosclerosis and cardiovascular disease
Calcium intake and vascular calcification Osteoporosis
Weak bones cause heart attack and stroke Prevention protocols
       

shadow

BioPQQ™ is a trademark of MGC (Japan).