Life Extension Final Clerance Sale

Life Extension Update

Vitamin D supplementation improves outcome in men with low-risk prostate cancer

Vitamin D supplementation improves outcome in men with low-risk prostate cancer

Friday, December 21, 2012. An article published this year in the Journal of Clinical Endocrinology & Metabolism reports the findings of a trial conducted by researchers at the Medical University of South Carolina which revealed a benefit for supplementing with vitamin D among men whose prostate cancer was at low risk of progression into a more aggressive form. Men with low risk prostate cancer frequently receive regular monitoring, as opposed to undergoing surgery or radiation which can cause unwanted effects such as urinary incontinence.

The trial included 48 African-American and Caucasian men with low-risk prostate cancer who received 4,000 international units (IU) vitamin D3 for one year. Prostate biopsies were conducted before and after the treatment period. Nineteen men diagnosed with prostate cancer who underwent biopsies at a similar interval served as controls. Prostate-specific antigen (PSA), 25-hydroxyvitamin D and other factors were measured in treated subjects at the beginning of the trial and every two months through its conclusion.

Supplementation corrected all cases of vitamin D insufficiency of deficiency observed prior to treatment. Fifty-five percent of the vitamin D-treated subjects had fewer cancerous cores in their biopsied tissue or improved Gleason scores (which evaluate the prognosis of cancerous prostate tumors) at the end of the trial. In contrast, progression occurred in 63 percent of the men in the untreated control group. No significant change in PSA levels were noted.

"Increasing numbers of patients diagnosed with low-risk prostate cancer are electing active surveillance due to the relative indolent nature of the disease as well as the risks of side effects from definitive treatment (surgery or radiation therapy)," David T. Marshall and colleagues write. "The combination of active surveillance and vitamin D3 supplementation at 4000 IU/d resulted in a decreased number of positive cores at repeat biopsy in more than half of patients diagnosed with low-risk prostate cancer."

"Our next objective is to conduct a definitive, randomized trial to validate the effectiveness of vitamin D3 supplementation in active surveillance, using an intervention strategy that is extremely cost effective and easy to implement."

The trial's findings were included in a review article by the same authors which appeared online on December 7, 2012 in The Journal of Steroid Biochemistry and Molecular Biology. Bruce W. Hollis and coauthors note that a year of supplementation eliminated differences in circulating vitamin D levels observed between Caucasian and African American participants, and they suggest that vitamin D3 supplementation could reduce prostate cancer-related health disparities.

"Vitamin D3 supplementation may not only provide a significant addition to active surveillance, but also help us avoid the overtreatment of low-risk disease in subjects who respond to an intervention strategy that appears to be safe and is extremely cost-effective," they write. "At the same time, this non-toxic regimen would help us identify those patients (non-responders) who are affected by potentially aggressive disease and should consider definitive treatment."

shadow
What's Hot Highlight

Prostate cancer risk increases with pan fried meat consumption

What's Hot

In an article published online on July 20, 2012 in the journal Carcinogenesis, associate professor of preventive medicine Mariana Stern of the University of Southern California's Keck School of Medicine and her colleagues reveal an association between pan fried meat intake and a higher risk of prostate cancer.

"We found that men who ate more than 1.5 servings of pan-fried red meat per week increased their risk of advanced prostate cancer by 30 percent," reported Dr Stern. "In addition, men who ate more than 2.5 servings of red meat cooked at high temperatures were 40 percent more likely to have advanced prostate cancer."

The study analyzed data from 717 men with localized prostate cancer, 1,140 advanced cases and 1,096 men without the disease who were enrolled in the California Collaborative Prostate Cancer Study. Questionnaires completed by the subjects provided information on poultry and red meat intake, including cooking practices.

The team uncovered an association between advanced prostate cancer and a high intake of red meat cooked at high temperatures, as well as with well done meat. A reduction in the risk of advanced disease was correlated with baked poultry intake. When meat intake was examined by type, hamburger was found to increase prostate cancer risk. "We speculate that these findings are a result of different levels of carcinogen accumulation found in hamburgers, given that they can attain higher internal and external temperatures faster than steak," Dr Stern commented.

"The observations from this study alone are not enough to make any health recommendations, but given the few modifiable risk factors known for prostate cancer, the understanding of dietary factors and cooking methods are of high public health relevance," she remarked.

Wishing You a Wonderful Holiday Season with Super Sale Savings!

Annual Super Sale on Now!

Get these breakthrough products to help you stay younger and healthier longer. Stock up on all the health essentials you need all year!

Below are only a few examples of the significant savings you'll find during this year's Super Sale:

Extraordinary Enzymes,
60 capsules

Item #01706

$26.00
$16.20*

PQQ Caps with BioPQQ™,
10 mg, 30 vegetarian capsules

Item #01500

$24.00
$14.85*

Krill Healthy Joint Formula,
30 softgels

Item #01600

$32.00
$19.58*

Super K with Advanced K2 Complex, 90 softgels
Item #01724

$30.00
$18.23*

Optimized Resveratrol with Synergistic Grape-Berry Actives, 250 mg, 60 vegetarian capsules
Item #01430

$46.00
$27.90*

Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™, 100 mg, 60 softgels
Item #01426

$62.00
$35.10*

*Price based on super sale member volume purchase.

http://www.lef.org/SuperSale/

Latest Supplements

Optimized Quercetin

Rich Rewards™ Breakfast Blend,
12 oz.

Item #01609

add to cart

Like fruits and vegetables, unroasted coffee beans are naturally packed with antioxidant polyphenols. Among the most beneficial of these is chlorogenic acid, a potent antioxidant which promotes optimal health.

Unfortunately, the antioxidants in most coffee beans are typically destroyed during the roasting process that's required to create a rich dark blend. So Rich Rewards™ Breakfast Blend is made from organic Arabica beans using a patented, 100% natural process called HealthyRoast™ which delivers a more complete nutritional profile of the coffee bean, yielding chlorogenic acid levels far greater than other premium brands. And all without sacrificing a drop of rich gourmet flavor.

Kyolic® Garlic Formula 102

Advanced Anti-Adipocyte Formula with AdipoStat and Integra-Lean®*,
60 vegetarian capsules

Item #01509

add to cart

AdipoStat targets the mechanisms by which fat-storing cells or adipocytes become bloated and metabolically dysfunctional . . . leading to excess fat accumulations in the belly and throughout your body.

  1. AdipoStat targets adipocyte (fat cell) creation.
  2. It impedes adipocyte growth (adipogenesis).
  3. And induces fat in adipocytes to break down (lipolysis).

After careful scientific analysis of numerous plant extracts, researchers identified the two species included in AdipoStat that target adipocytes: Sphaeranthus indicus flower and the mangosteen fruit (Garcinia mangostana). Optimal results were shown in studies when these two plant extracts were combined.

AdipoStat's performance in clinical studies indicates it can safely deliver impressive results.

*This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

shadow

Highlight

Life Extension Update What's Hot
Poor survival among African-American cancer patients could be explained by low vitamin D levels High dose vitamin D supplementation eliminates disparity
Government-sponsored study reveals current vitamin D recommendations are inadequate for African-Americans and others Vitamin D protects the prostate
High blood vitamin D levels reduce risk of prostate cancer Vitamin D receptor gene variations increase the risk of breast and prostate cancer
       
Life Extension Magazine® Health Topics
Advances in prostate cancer chemoprevention and treatment Prostate cancer / prostate health
Vitamin D: cancer prevention and other new uses Cancer adjuvant therapy
Avoiding prostate cancer Complementary alternative cancer therapies
       

shadow

AdipoStat is a proprietary ingredient derived from natural plant extracts exclusively distributed by InterHealth N.I.
Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. BioPQQ™ is a trademark of MGC (Japan).