Life Extension Final Clerance Sale

Life Extension Update

Late age-related macular degeneration risk lower among men and women with high omega-3

Late age-related macular degeneration risk lower among men and women with high omega-3

Tuesday, February 19, 2013. An article published online on February 13, 2013 in The Journal of Nutrition reports an association between high omega-3 polyunsaturated fatty acid (PUFA) levels and a reduced risk of age-related macular degeneration (AMD) in older men and women.

The investigation included 963 participants in The Antioxydants Lipides Essentiels Nutrition et Maladies Occulaires (Alienor) Study of residents of Bordeaux, France aged 73 and older. Blood samples collected between 1999 and 2001 were analyzed for plasma alpha-linolenic acid and the long-chain omega-3 fatty acids eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA). The subjects underwent eye examinations during 2006-2008 and were followed for an average of 31 months, during which 72.4 percent of the participants were re-examined.

Macular degeneration was more prevalent in older versus younger participants although its incidence in men and women was similar. Having a higher level of total omega-3 fatty acids was associated with a decreased adjusted risk of late AMD in comparison with lower levels. When the effects of individual omega-3 fatty acids were separately analyzed, higher levels of alpha-linolenic acid and DHA were found to be significantly protective.

"Biomarkers of omega-3 PUFA, including plasma and erythrocyte omega-3 PUFA, have been evaluated in numerous studies, showing good correlation with dietary intake and sensitivity to change in supplementation studies," Bénédicte M. J. Merle and colleagues write. "Such biomarkers have been widely used in studies on the associations of omega-3 PUFA with a variety of health outcomes (cardiovascular diseases, obesity and diabetes, neuropsychiatric disorders, cancers). However, to our knowledge, no published epidemiological study of AMD included measurements of biomarkers of omega-3 PUFA status."

"This study gives further support to the potential role of omega-3 PUFAs in the prevention of late AMD and highlights the necessity of randomized clinical trials to determine more accurately the value of omega-3 PUFAs as a means of reducing AMD incidence."

shadow
What's Hot Highlight

Experiments show Alzheimer plaques reduced by vitamin D and DHA

What's Hot

The February 5, 2013 issue of the Journal of Alzheimer's Disease published the finding of researchers at the University of California, Los Angeles that active forms of vitamin D3 and docosahexaenoic acid (DHA) improve the ability of immune cells known as macrophages to clear amyloid-beta, a toxic protein that occurs in elevated amounts in the brains of Alzheimer's disease patients. Milan Fiala and his colleagues "suggest that low vitamin D3 and docosahexaenoic acid intake and/or poor anabolic production of 1,25D3/resolvin D1 in peripheral blood mononuclear cells could contribute to Alzheimer's disease onset/pathology."

The team isolated macrophages from the blood of individuals with Alzheimer's disease and healthy control subjects and incubated them with amyloid-beta prior to administering 1alpha, 25-dihydroxyvitamin D3 (1,25D3) or resolvin D1, an active form of DHA. While both nutrients increased the macrophages' ability to remove amyloid-beta and decrease amyloid-beta-induced cell death, they did so by utilizing different receptors.

The authors observe that macrophages from Alzheimer's disease patients express inflammatory genes in different ways than the controls and that transcription of specific inflammatory genes is increased or decreased in these patients. "Further study may help us identify if these two distinct transcription patterns of inflammatory genes could possibly distinguish either two stages or two types of Alzheimer's disease," remarked coauthor Mathew Mizwicki.

"Our new study sheds further light on a possible role for nutritional substances such as vitamin D3 and omega-3 in boosting immunity to help fight Alzheimer's," Dr Fiala stated. "We may find that we need to carefully balance the supplementation with vitamin D3 and omega-3 fatty acids, depending on each patient in order to help promote efficient clearing of amyloid-beta. This is a first step in understanding what form and in which patients these nutrition substances might work best."

Free Webinar

Preventing Heart Attacks, Naturally

Hosted by Michael A. Smith, M.D.

Wednesday, February 20, 2013
7 PM—8 PM ET

Please join Life Extension®'s webinar on Preventing Heart Attacks, Naturally. Michael Smith, MD, will present steps for protecting yourself against our nation's number one killer. Dr. Mike is known by his fans as the "country doctor with a city education." He's passionate, energetic and informative.

You can also listen to Dr. Mike live on Healthy Talk radio, Wednesdays from 1-2 PM ET. For more information, visit www.lef.org/healthytalk.

Register Now
Reserve your webinar seat now at: https://www2.gotomeeting.com/
register/911350354

After registering, you will receive a confirmation e-mail containing information about joining the webinar.

System Requirements

PC-based attendees
Required: Windows® 7, Vista, XP or 2003 Server

Macintosh®-based attendees
Required: Mac OS® X 10.5 or newer

Mobile attendees
Required: iPhone®, iPad®, Android™ phone or Android Tablet

Visit www.lef.org/media to view past webinars!

Latest Supplements

Super Saw Palmetto/Nettle Root Formula with Beta-Sitosterol, 60 softgels
Item #01408

add to cart

The saw palmetto berry (Serenoa repens) is rich in bioactive, high-molecular weight compounds including beta-sitosterol. It has been shown to interfere with DHT activity in the prostate, inhibit alpha-adrenergic receptor activity (to support normal urinary flow), and help control inflammatory actions in the prostate gland.

Super Saw Palmetto/Nettle Root Formula with Beta-Sitosterol combines the USPlus® saw palmetto CO2 DeepExtract™ with a nettle root extract (Urtica dioica), boron, and rosemary to support a healthy prostate.

USPlus® and DeepExtract™ are trademarks of Valensa International and are used under license. US Patents 6,319,524 and 6,669,968.

Kyolic® Garlic Formula 102

Vitamin D3 with Sea-Iodine™, 5,000 IU, 60 capsules
Item #01573

add to cart

Sea-Iodine™ is a low-cost proprietary formula that health conscious individuals can take each day to support optimal iodine levels. Using standardized extracts harvested from a blend of marine algae, Sea-Iodine™ brings you the health of the sea while avoiding the well known dangers of excessive salt intake. The purified extracts found in Sea-Iodine™ come from the pristine waters of Iceland and Nova Scotia, providing over 667% of the Recommended Daily Value of natural iodine.

For those members who would like the convenience and economy of taking vitamin D and Sea-Iodine™ in just one capsule, Life Extension® offers Vitamin D3 with Sea-Iodine™. As a result of startling evidence of a widespread vitamin D deficiency, prominent nutritional scientists are calling on Americans to increase their vitamin D intake to 1000 IU per day and higher.

shadow

Highlight

Life Extension Update What's Hot
Omega 3, vitamin A slow the progression of devastating eye disease Decreased risk of macular degeneration found in women who consume more fish and omega-3
Greater omega-3 fatty acid intake associated with protection against advanced age-related macular degeneration Researchers explore omega-3 mechanisms in neovascular eye disease
Studies associate omega-3 fatty acid intake with reduced risk of macular degeneration Omega-3 fatty acids associated with protection against macular degeneration
       
Life Extension Magazine® Health Topics
Halt the leading cause of age-related blindness Age-related macular degeneration
The missing link in combating macular degeneration Eye health
Omega-3 fatty acids: vital to a longer, healthier life Prevention protocols
       

shadow