Whole Body Health Sale

Life Extension Update

Activation of SIRT1 through calorie restriction or drug treatment delays neurodegeneration in experimental model

Activation of SIRT1 through calorie restriction or drug treatment delays neurodegeneration in experimental model
Photo courtesy of Li-Huei Tsai, PhD

Tuesday, May 21, 2013. The May 22, 2013 issue of the Journal of Neuroscience includes an article by researchers at the Massachusetts Institute of Technology (MIT) which reports an association between a calorie restricted diet and a delay in the decline in brain function that occurs in a mouse model of neurodegeneration.

The study utilized a breed of mice in which neurodegeneration is induced by administration of the drug doxycycline. Li-Huei Tsai, PhD of the Picower Institute for Learning and Memory, Howard Hughes Medical Institute, and Broad Institute of Harvard University and Massachusetts Institute of Technology and associates fed the animals a diet which reduced by 30 percent the amount of calories that would have been normally consumed by mice given unlimited food access. A control group of the same breed of mice matched for age and gender were allowed unlimited feeding.

After three months on the diet, tests of learning and memory revealed better cognitive function in the mice that received restricted diets. Examination of the animals' brains revealed a reduction in the loss of neurons and greater brain mass and synaptic density in the restricted animals in comparison with those provided with unrestricted diets. "We not only observed a delay in the onset of neurodegeneration in the calorie-restricted mice, but the animals were spared the learning and memory deficits of mice that did not consume reduced-calorie diets," Dr Tsai reported.

The researchers found an increase in the expression of a protein believed to regulate lifespan known as SIRT1 in the hippocampus area of the calorie restricted animals' brains as well as an increase in SIRT1 activity, which is consistent with other studies involving calorie restriction. When a separate group of mice were given a SIRT1-activating compound, benefits similar to those elicited by calorie restriction were observed. "The question now is whether this type of treatment will work in other animal models, whether it's safe for use over time, and whether it only temporarily slows down the progression of neurodegeneration or stops it altogether," Dr Tsai remarked.

"There has been great interest in finding compounds that mimic the benefits of caloric restriction that could be used to delay the onset of age-associated problems and/or diseases," commented Luigi Puglielli, MD, PhD, who has participated in research involving calorie restriction and aging at the University of Wisconsin, Madison. "If proven safe for humans, this study suggests such a drug could be used as a preventive tool to delay the onset of neurodegeneration associated with several diseases that affect the aging brain."

shadow
What's Hot Highlight

Berries improve neuronal housekeeping

What's Hot

In an abstract summarizing the results of a study reported at the Experimental Biology 2013 meeting, published on April 9, 2013 in The FASEB Journal, researchers from Tufts University report a benefit for strawberry and blueberry consumption in improving autophagy in the brain. Autophagy is a process employed by the body to clear the accumulation of unnecessary or damaged cellular components that have been implicated in some disorders. "Most diseases of the brain such as Alzheimer's and Parkinson's have shown an increased amount of toxic protein," explained research team member Shibu Poulose, PhD, of Tufts' Human Nutrition Research Center on Aging. "Berries seem to promote autophagy, the brain's natural housekeeping mechanism, thereby reducing the toxic accumulation."

In a study led by Dr Barbara Shukitt-Hale, rats were provided with a control diet or a diet supplemented with strawberries or blueberries for two months prior to and 30 days following irradiation of the brain (which results in oxidative and inflammatory stress to that organ). Some of the animals underwent examination of their brains 36 hours following irradiation and the remaining animals were examined after 30 days.

The team observed a reduction in inflammation and oxidative stress in rats that received diets enhanced with either berry, as well as improved indicators of autophagy activation in comparison with untreated animals. "After 30 days on the same berry diet, the rats experienced significant protection against radiation compared to control," Dr Poulose reported. "We saw significant benefits to diets with both of the berries, and speculate it is due to the phytonutrients present."

"We have a lot of animal work that suggests these compounds will protect the aged brain and reverse some of behavioral deficits," stated Dr Shukitt-Hale. "We are hoping it will translate to human studies as well."

Healthy Talk Radio

Are Statin Drugs really the answer?

Activation of SIRT1 through calorie restriction or drug treatment delays neurodegeneration in experimental model 

Hosted by Michael A. Smith, M.D.

Thursday, May 23 at 3 p.m.

Want to hear some Healthy Talk? Then tune in to Dr. Michael Smith's talk show on Thursday, May 23 at
3 p.m. on www.RadioMD.com. Learn about a remarkable new book entitled Statins: Miraculous or Misguided, written by Mark J. Estren, Ph.D. This Pulitzer-winning journalist was formerly the producer of "Report on Medicine" for CBS Radio.

Dr. Mike and Dr. Estren will discuss the misinformation that abounds about statin drugs. Contrary to popular belief, most cholesterol in the body doesn't come from foods. It is made by the body itself. And statins work because they interfere with the body's ability to manufacture cholesterol. But is that really a good thing? If you or someone you love has been taking statins, you won't want to miss this episode of Healthy Talk with Dr. Mike … the "country doctor with a city education." It's your chance to discover smart new ways to deal with your cholesterol!

http://www.healthytalkmd.com/

Latest Supplements 


Natural Estrogen with Pomegranate Extract, 60 caplets
Item #01692

add to cart

Natural Estrogen with Pomegranate Extract contains standardized plant extracts that may help produce hormone-like modulating effects that are beneficial for most women over 40. This formula contains health-promoting phytoestrogens and polyphenols that confer powerful hormone-modulating and DNA-protecting effects.

Natural Estrogen provides the following complementary plant extracts:

  • Black cohosh to reduce menopausal discomforts
  • Licorice to provide beneficial estrogen-like effects
  • HMRlignan™ extract to protect against some of estrogen's unwanted effects
  • Broccoli extract to help modulate estrogens and maintain healthy cell division
  • Dong quai is believed in Chinese medicine to help with menstruation and menopausal symptoms
  • Vitex agnus-castus to establish hormone balance and suppress excess prolactin
  • Punicalagins, derived from pomegranate, are the main polyphenol responsible for this super fruit's multiple health benefits, to provide antioxidant activity
Kyolic® Garlic Formula 102

Water-Soluble Pumpkin Seed Extract, 60 vegetarian capsules
Item #01209

add to cart

Aging individuals frequently encounter a weakening of the bladder and its sphincter muscle that controls the release of urine.

Laboratory and human clinical studies demonstrate that ingestion of water-soluble pumpkin seed extract can significantly improve the structural support of the bladder and the function of the sphincter muscle. The data supporting the value of water-soluble pumpkin seed extract is particularly strong in studies performed in women. A clinical study of aging men also demonstrated positive results.

The pumpkin seed has a long history of use in helping to maintain healthy bladder function. Japanese scientists have patented a method to obtain the water-soluble constituents of the pumpkin seed, which are absorbed far more efficiently into the bloodstream. These water-soluble pumpkin seed extracts appear to be the active constituents to help with the urinary discomforts endured by so many maturing women and men.

shadow

Highlight 

Life Extension Update What's Hot
Calorie restriction, exercise rejuvenate nerve connections Calorie restriction helps regulate glucose and maintain gray matter volume in aged primate model
Calorie restriction reduces Alzheimer's disease neuropathology in monkeys Fewer calories mean better memory for seniors
Mechanism defined for calorie restriction's preventive benefit in Alzheimer's disease Calorie restriction protects brains
Life Extension Magazine® Health Topics
Activate your longevity genes: five natural compounds simulate caloric restriction Caloric restriction for improved health and lifespan
Longevity genes and caloric restriction Age related cognitive decline
Calorie restriction, exercise, hormone replacement and phytonutrients fight aging Alzheimer's disease

shadow