Life Extension Final Clerance Sale

Life Extension Update

Metformin aids in the stabilization of metastatic prostate cancer

Metformin aids in the stabilization of metastatic prostate cancer

Tuesday, May 6, 2014. An article published this year in European Urology reports the outcome of a Swiss trial involving men with castration-resistant prostate cancer (defined as a testosterone level of less than 50 ng/dL with progressive disease) who were given the antidiabetic drug metformin.

"Metformin has antiproliferative effects in preclinical models of prostate cancer via reduction of systemic insulin levels and inhibition of mammalian target of rapamycin (mTOR)," write authors Christian Rothermundt and his colleagues in their introduction. "In a recent population-based evaluation among 3837 diabetic patients with prostate cancer, metformin use was associated with reduced prostate cancer-specific mortality and reduced all-cause mortality."

For the trial, 44 nondiabetic men who had not been treated with chemotherapy for progressive, metastatic prostate cancer causing few or no symptoms were given 1000 milligrams metformin two times per day until disease progression. Assessment of disease status, including computed tomography of the abdomen, pelvis and chest; bone scanning, and serum prostate cancer specific antigen (PSA) level measurement was conducted every twelve weeks.

At twelve weeks, 36% of the group was progression-free, and 9% were still progression-free at 24 weeks. PSA doubling time, a measure of disease progression, was prolonged in more than half of the participants after starting metformin. The drug was also associated with improved insulin sensitivity.

"To our knowledge, this is the first prospective clinical trial reporting on treatment with the biguanide metformin in patients with progressive castration-resistant prostate cancer," the authors announce. "Testing metformin in an earlier prostate cancer disease setting and in combinations is of great interest, especially considering the additional effect of metformin on metabolic parameters," they conclude.


What's Hot

Higher dose metformin associated with improved survival among colorectal cancer patients

What's Hot

The journal Cancer Epidemiology, Biomarkers & Prevention published an article on June 10, 2013 which reports a benefit for the antidiabetic drug metformin in colorectal cancer survival.

The study involved 3,816 men and women with stage I-III colorectal cancer diagnosed between 2001 and 2006, including 207 diabetics who had been prescribed metformin, 108 diabetics who did not use the drug and 3,501 nondiabetics. The subjects were followed through 2010, during which 196 deaths occurred among those with diabetes and 1,897 occurred among the nondiabetics. Among the diabetic patients, 93 deaths were due to colorectal cancer, and 1,082 nondiabetic deaths were attributable to the disease.

When subjects treated with metformin were compared to diabetics who did not use the drug, a reduction in the risk of death due to colorectal cancer that "approached significance" was observed. However, those whose use of metformin was categorized as high intensity (higher dose), had a 56% lower risk of dying of the disease than diabetics who did not use the drug. Metformin use was additionally associated with a 31% lower adjusted risk of dying from any cause among diabetic subjects over follow-up.

"This study is the first, to the authors' knowledge, to assess the presence of an exposure response effect between increasing metformin use and colorectal cancer outcomes," authors Susan C. Spillane and her colleagues at St James Hospital in Dublin announce. "Significant associations were observed in stratified analyses of high intensity exclusive metformin usage and the results also suggest that metformin exposure may potentially improve survival relative to non-diabetic patients. Additional studies in larger population-based cohorts are required to further explore the influence of varying exposure levels and timing and to determine if any patient subgroups are more likely to benefit from metformin."



Pay Remarkably Low Prices for your Blood Tests!

Super Sale

Annual blood tests are far and away the best tool for heading off disease. And right now, during the Annual Life Extension Blood Test Super Sale, members can save up to 50% off the retail price on over 200 different blood tests and blood panels. Assess your cardiac risk factors, hormone levels, nutritional status, and much more.

Aging is fundamentally a metabolic process. With the right science-based health information, you could be more proactive now to pre-empt or postpone the diseases of aging. That's where the Healthy Aging Panels come in.

Healthy Aging Panel—Basic
Item #LC100025


Healthy Aging Panel—Comprehensive
Item #LC100026

Is hormonal imbalance keeping you from reaching your weight loss goals? The new Weight Loss Panels are designed to measure the basic hormones that can contribute to weight gain.

Weight Loss Panel—Basic
Item #LC100027


Weight Loss Panel—Comprehensive
Item #LC100028


Now through June 2, 2014, take advantage of the extra-discounted price on any Life Extension blood tests* that focus on a particular health concern of yours. There is a wide selection of tests available. So don't wait.

*The only exceptions are the 24-hour urinary hormone profile, LEAP food sensitivity, and cytokine tests.
** Blood tests available only in the continental United States. Restrictions apply in NY, NJ, PA, RI and MA. Not available in Maryland.


Latest Products

Vitamin D3, 1000 IU, 90 softgels
Item #01753

add to cart

Vitamin D has long provided significant support for healthy bone density. However, scientists have also validated the critical role that vitamin D plays in regulating healthy cell division and differentiation, and its profound effects on human immunity. These findings link a deficiency of vitamin D to a host of common age-related problems.

The current RDA is only 600 IU. As a result of startling evidence of a widespread vitamin D deficiency, prominent nutritional scientists are calling on Americans to increase their vitamin D intake to 1,000 IU per day and higher. Currently, most experts in the field believe that intakes of between 1,000 and 10,000 IU for adults will lead to serum 25(OH)D levels above those indicative of vitamin D deficient levels, at approximately 80 nmol/L or 32 ng/mL.

Kyolic® Garlic Formula 102

Super Omega-3 EPA/DHA with Sesame Lignans & Olive Fruit Extract, 240 easy to swallow softgels
Item #01619
add to cart

add to cart

Studies associate the Mediterranean diet — rich in omega-3 fatty acids, monounsaturated fatty acids such as that found in olive oil, and antioxidant-rich fruits, vegetables, and herbs — with cardiovascular health and increased life span. Other studies support omega-3's importance in cardiovascular health.

Life Extension's Super Omega-3 is a premium, scientifically validated fish oil concentrate, derived from sustainable sources, that contains a proprietary, full-spectrum blend of synergistic nutrients to provide scientifically validated cardioprotective health benefits.

An abundance of scientific research substantiates the wide-ranging health benefits of omega-3 fatty acids in fish oil and monounsaturated fatty acid and polyphenols in olive fruit. No other commercially available fish oil supplement contains this level of essential fatty acids, sesame lignans and olive fruit polyphenols.


Related Articles

Life Extension Update
Life Extension Update
What's Hot
What's Hot
Life Extension Magazine®
Life Extension Magazine®
Health Topics
Health Topics