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Vitamins, Health Supplements, Anti Aging Supplements: Life Extension Update

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Vitamins, Health Supplements, Anti Aging Supplements: Life Extension Update 

Metformin aids in the stabilization of metastatic prostate cancer

Tuesday, May 6, 2014. An article published this year inEuropean Urology reports the outcome of a Swiss trial involving men with castration-resistant prostate cancer (defined as a testosterone level of less than 50 ng/dL with progressive disease) who were given the antidiabetic drug metformin.

"Metformin has antiproliferative effects in preclinical models of prostate cancer via reduction of systemic insulin levels and inhibition of mammalian target of rapamycin (mTOR)," write authors Christian Rothermundt and his colleagues in their introduction. "In a recent population-based evaluation among 3837 diabetic patients with prostate cancer, metformin use was associated with reduced prostate cancer-specific mortality and reduced all-cause mortality."

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