Tuesday, May 19, 2015. On April 27, 2015, the journal Diabetes & Metabolism reported the outcome of a trial of men and women with low magnesium levels and prediabetes which found an improvement in glycemic status among those who received magnesium.
The study included 116 participants between the ages of 30 to 65 years with newly diagnosed prediabetes and serum magnesium levels of 1.8 milligrams per deciliter (mg/dL) or less. Subjects were advised to follow dietary and physical activity guidelines over the course of the study and were randomized to groups that received a magnesium chloride solution providing 382 mg magnesium or a control solution daily for four months. Fasting and two-hour post-load plasma glucose, serum magnesium and other factors were assessed at the beginning and end of the treatment period.
At the study's conclusion, fasting and post-load glucose levels, insulin resistance and triglycerides had significantly decreased among those who received magnesium, and an increase was observed in magnesium levels and high density lipoprotein (HDL) cholesterol levels.
"The percentage of subjects who improved their prediabetic state was significantly larger among those taking magnesium chloride compared with those in the control group, whereas unfavorable changes in prediabetic state were significantly higher in the controls than in those taking magnesium," authors Martha Rodriguez-Morán and colleagues report. "Our results support the hypothesis that, as a complement to lifestyle interventional programs, people with prediabetes and hypomagnesemia also should take magnesium supplements to decrease plasma glucose levels and potentially reduce the transition rate from prediabetes to diabetes. In this regard, given that measurement of serum magnesium is easy and accessible, the potential benefits of magnesium supplementation could readily be achieved in clinical settings."