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Granulocyte colony-stimulating factor improves liver function in alcoholic hepatitis

Granulocyte colony-stimulating factor improves liver function in alcoholic hepatitis Tuesday, September 23, 2014. A pilot study reported in the September, 2014 issue of The American Journal of Gastroenterology found a benefit for the administration of granulocyte colony-stimulating factor (G-CSF) in patients with severe alcoholic hepatitis, a condition with high short-term mortality. "Both animal and human studies have suggested that CD34 + cells might contribute to hepatic regeneration and repair after various forms of acute liver injury," write authors Virendra Singh, MD, and colleagues. "In animal models of liver injury, bone marrow–derived circulating pluripotent cells [stem cells] are reported to participate in hepatic regeneration, which may be dependent on the type of liver injury and experimental conditions. Several studies have demonstrated the safety and efficacy of granulocyte colony-stimulating factor in promoting the mobilization of bone marrow stem cells, leading to improved histology and survival after liver injury. Recent studies using G-CSF as a treatment modality in patients with acute-on-chronic liver failure (ACLF) have shown clinical, biochemical, and histological improvement in liver function." Among 46 men who received standard medical therapy for severe alcoholic hepatitis, 23 received subcutaneous G-CSF twice daily for five days.

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