Life Extension Update

Vitamins, Health Supplements, Anti Aging Supplements: Life Extension Update

Life Extension Update is a free email newsletter sent to subscribers twice weekly. Our premier e-mail update features information and breaking news about longevity, vitamins, nutritional health supplements, anti aging supplements, and other life extension topics to assist you in living longer and healthier.

Newsletters will be posted in this archive two weeks after they are sent to subscribers. Subscribe today to stay informed of the latest in health and nutrition news as it happens!

Life Extension Update

SAMe improves depression

Life Extension Update

Tuesday, June 16, 2015. Research described in the April 2015 issue of Advances in Integrative Medicine revealed that the addition of the nutritional supplement S-adenosylmethionine (SAMe) to selective serotonin reuptake inhibitor (SSRI)-therapy improved symptoms in adults who failed to optimally respond to drugs.

"Pharmacotherapy achieves acceptable results for about 30% of patients, mixed results for 40% and poor results for 30% of patients," write authors Matthew Bambling of Australia's University of Queensland and colleagues in their introduction to the article. "As a result of poor or variable response to treatment, a significant proportion of depressed patients may not experience complete clinical remission of their depression. Treatment response is complicated further by poor patient tolerability of medications due to unwanted side effects."

Acting on the positive findings of a clinical trial that involved the use of high dose SAMe in depressed serotonin-reuptake inhibitor non-responders, Dr Bambling and associates compared the effects of adding fifteen weeks of high dose (1600 mg) and low dose (800 mg) SAMe supplementation to the regimens of 36 SSRI-treated men and women who had suboptimal treatment response. Tests administered before and after treatment evaluated depressive symptoms.

Thirty-five percent of those who completed the first study experienced improvement in mood and symptoms by the end of the trial in comparison with pretreatment measures. The researchers found that the low and high doses of SAMe were equally effective.

In their discussion of the findings, the authors note "We consider it likely that 800 mg a day of SAMe is the required therapeutic dose for treatment response". The researchers also reported that treatment with SAMe "…resulted in significant and meaningful improvements in mood and quality of life for the majority of participants."

The authors acknowledged the Life Extension Foundation® for donating the SAMe product used in the study.

View This Issue

Recent NewsLetter Articles

Back issues of Life Extension Update are archived approximately two weeks following their publication. To make sure you have not missed out on exciting news concerning health and nutrition, vitamins, and the health supplements you rely on for optimal health, check here for a list of issues of Life Extension Update.

Life Extension Update Archive