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DEPRENYL



Table of Contents

image Deprenyl Prevents Protein Oxidation
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Deprenyl And 'Excess Mortality'

image The clinical potential of Deprenyl in neurologic and psychiatric disorders
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Monoamine oxidase B inhibitors. Current status and future potential

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The effect of L-deprenyl on spatial short term memory in young and aged dogs

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Effects of selegiline (deprenyl) on cognition in early Parkinson's disease

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Rationale for (-)-deprenyl (Selegiline) therapy in Parkinson's disease and Alzheimer's disease

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Rationale for (-)deprenyl (selegiline) medication in Parkinson's disease and in prevention of age-related nigral changes

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Effect of long-term treatment with L-deprenyl on the age-dependent microanatomical changes in the rat hippocampus

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Therapy with l-deprenyl (selegiline) and relation to abuse liability

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The interaction of L-deprenyl and scopolamine on spatial learning/memory in rats

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The pharmacological basis of the beneficial effects of (-)deprenyl (selegiline) in Parkinson's and Alzheimer's diseases

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An interim report of the effect of selegiline (L-deprenyl) on the progression of disability in early Parkinson's disease

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Pharmacological basis of the therapeutic effect of (-)deprenyl in age-related neurological diseases

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(-)Deprenyl-medication: A strategy to modulate the age-related decline of the striatal dopaminergic system

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Monoamine oxidase inhibitors: Reversible and irreversible

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The pharmacological profile of (-)deprenyl (selegiline) and its relevance for humans: A personal view

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L-deprenyl therapy improves verbal memory in amnesic alzheimer patients

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A pilot study of low-dose L-deprenyl in Alzheimer's disease

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Potential applications for monoamine oxidase B inhibitors

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Monoamine oxidase and dementia: Treatment with an inhibitor of MAO-B activity

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Neuropsychological effects of L-deprenyl in Alzheimer's type dementia

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The effect of R-(-)-deprenyl in de novo parkinsonian patients pretreated with levodopa and decarboxylase inhibitor correlated to depression and MHPG, HIAA and HVA levels in the cerebrospinal fluid

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Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma

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Selective inhibition of MAO-A, not MAO-B, results in antidepressant-like effects on DRL 72-s behavior



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Brief information on an early phase-II-study with deprenyl in demented patients

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L-Deprenyl in Alzheimer's disease. Preliminary evidence for behavioral change with monoamine oxidase B inhibition

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Cognitive effects of L-deprenyl in Alzheimer's disease

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Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: Electrophysiological studies in the rat central nervous system

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Tyramine pressor sensitivity changes during deprenyl treatment

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The facilitation of dopaminergic activity in the aged brain by (-)deprenyl. A proposal for a strategy to improve the quality of life in senescence

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l-Deprenyl in atypical depressives

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The effect of deprenyl (selegiline) on cognition and emotion in parkinsonian patients undergoing long-term levodopa treatment

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Deprenyl (selegiline) combined with levodopa and a decarboxylase inhibitor in the treatment of Parkinson's disease

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Deprenyl (selegiline) in combination treatment of Parkinson's disease

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L-deprenyl plus L-phenylalanine in the treatment of depression

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L-deprenyl, a selective monoamine oxidase type-b inhibitor in endogenous depression

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Effects of selective monoamine oxidase (MAO) inhibitors on conditioned avoidance responses (CAR) of rats

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Deprenyl in Parkinson's disease

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The effect of selective MAO inhibitors on the conditioned avoidance response of Wistar rats

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Deprenyl induces the tyrosine hydroxylase enzyme in the rat dopaminergic nigrostriatal system

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Selegiline in the treatment of behavioural disturbance in Alzheimer's disease

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Deprenyl in the treatment of Parkinson's disease: Clinical effects and speculations on mechanism of action

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Modulation of gene expression rather than monoamine oxidase inhibition: (-)-Deprenyl-related compounds in controlling neurodegeneration

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L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro

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The natural history of Parkinson's disease

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Effect of lazabemide on the progression of disability in early Parkinson's disease

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Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP subjects not requiring levodopa

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New approaches to drug treatment of Parkinson's disease

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Novel sites of action for deprenyl in MPTP-parkinsonism: Metabolite-mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C57BL mice

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Combined treatment in Parkinson's disease

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In vivo comparison of the effects of inhibition of MAO-A versus MAO-B on striataI L-DOPA and dopamine metabolism

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Selegiline: A review of its clinical efficacy in Parkinson's disease and its clinical potential in Alzheimer's disease

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Combined treatment in Parkinson's disease

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Treatment of Parkinson's disease

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Clinical pharmacokinetics of drugs for Alzheimer's disease

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Anticonvulsant and antiepileptogenic effect of L-deprenyl (selegiline) in the kindling model of epilepsy

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Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats

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What is it that l-deprenyl (selegiline) might do?

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Slow recovery of human brain MAO B after L-deprenyl (selegeline) withdrawal

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Deprenyl enhances neurite outgrowth in cultured rat spinal ventral horn neurons

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Effect of L-Deprenyl, its structural analogues and some monoamine oxidase inhibitors on dopamine uptake

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Neuropsychological correlates of L-deprenyl therapy in idiopathic parkinsonism

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Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat

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Monoamine oxidase (MAO): Relationships to foods, poisons and medicines

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Deprenyl increases survival of rat foetal nigral neurones in culture

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Chronic treatment of aged mice with L-deprenyl produces marked striatal MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral lipofuscin accumulation

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Effect of selegiline (deprenyl) on the progression of disability in early Parkinson's disease

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Parkinson's disease: Past, present, and future

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Short-term beneficial effect of deprenyl monotherapy in early Parkinson's disease: A quantitative assessment

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Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

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Enhanced hydroxyl radical generation by 2'-methyl analog of MPTP: Suppression by clorgyline and deprenyl

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Neurotoxicity of levodopa on catecholamine-rich neurons

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A review of the pharmacology of selegiline

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Parkinson's disease: An epidemiologic method for distinguishing between symptomatic and neuroprotective treatments

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L-Deprenyl, levodopa pharmacokinetics, and response fluctuations in Parkinson's disease

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New approaches in the use of selegiline for the treatment of Parkinson's disease

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Two weeks of treatment with deprenyl (selegiline) does not prolong L-dopa effect in parkinsonian patients: A double-blind cross-over placebo-controlled trial

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Deprenyl in the treatment of symptom fluctuations in advanced Parkinson's disease

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Selegiline (1-deprenyl) and low-dose levodopa treatment of Parkinson's disease. A double-blind crossover trial

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Neurochemical insights into monoamine oxidase inhibitors, with special reference to deprenyl (selegiline)

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Problems associated with long-term levodopa treatment of Parkinson's disease

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Overview of present day treatment of Parkinson's disease

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The possible mechanisms of action of (-)deprenyl in Parkinson's disease