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PHOSPHATIDYLCHOLINE

TABLE OF CONTENTS

The hypocholesterolemic and antiatherogenic effects of topically applied phosphatidylcholine in rabbits with heritable hypercholesterolemia.

A report on phosphatidylcholine therapy in a Down Syndrome child.

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: Results of prospective double-blind controlled trial


PHOSPHATIDYLCHOLINE

The hypocholesterolemic and antiatherogenic effects of topically applied phosphatidylcholine in rabbits with heritable hypercholesterolemia.

 Hsia SL; He JL; Nie Y; Fong K; Milikowski C

 Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Florida 33101, USA.

 Artery (UNITED STATES) 1996, 22 (1) p1‑23

 

To test possible hypocholesterolemic and antiatherogenic effects of transdermally administered phosphatidylcholine (PC), we applied a 33% solution of PC in ethanol containing 0.01% butylated hydroxytoluene as antioxidant, to the shaved back of a strain of inbred rabbits which spontaneously developed hypercholesterolemia (serum cholesterol above 110 mg/dl) and severe atherosclerotic lesions especially in the aortic arch. After the topical application of PC, increases of choline‑containing phospholipids in blood were observed, reaching a plateau in 24‑48 hr. There were significant reductions in serum cholesterol and LDL cholesterol in thesions in the aortic arch were clearly less severe in the animals repeatedly treated with topical PC. The hypocholesterolemic and antiatherogenic effects of topical PC could be the result of increased cholesterol efflux from extrahepatic tissues and enhanced reverse cholesterol transport.

 

A report on phosphatidylcholine therapy in a Down Syndrome child.

 Psychological Reports 1986 Feb Vol 58(1) 207-217

 

Presents the case of a 21/2-yr-old Downs syndrome (DS) boy who was given a phosphatidylcholine supplement (150 mg/kg, day) over a 7-mo period. Measures of the EEG indicate a normalization during the treatment period with minor reoccurrence of abnormalities during a placebo period. S showed a definitive increase in speech and language skills as well as general motor skills that exceeded same-aged DS peers experiencing like training programs. Data suggest that phosphatidylcholine therapy may be useful for improving neurophysiological and intellectual functioning of some DS children.

 

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: Results of prospective double-blind controlled trial

 LIVER (DENMARK), 1982, 2/2 (77-81)

 

In a prospective double-blind trial, polyunsaturated phosphatidyl choline therapy (3 g/day) was given in addition to normal maintenance immunosuppressive therapy to 15 patients with HBsAg negative chronic active hepatitis. Histological evidence of disease activity was significantly reduced in the phospholipid-treated group. The results indicate that polyunsaturated phosphatidyl choline is of value as additional treatment in the management of patients with HBsAg negative chronic active hepatitis whose disease is inadequately controlled with conventional doses of immunosuppressive therapy.