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DIGESTIVE DISORDERS
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book Relief of chronic arterial obstruction using intravenous brinase. A control study.
book Pancreatic enzyme replacement therapy: comparative effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations on steatorrhoea in chronic pancreatitis.
book Unique features and application of non-animal derived enzymes.
book Enzyme Nutrition: The Food Enzyme Concept.
book Hepatoprotective activity of polyphenolic compounds from Cynara scolymnus against CCl4 toxicity in isolated rat hepatocytes.
book Die Artischocke - eine Heilpflanze mit Geschichte und zukunftperspektive.
book Antidyspeptische und lipidsenkende Wirkungen von Artischockenextrakt. Ergebnisse klinischer Untersuchungen zur Wirksamkeit und Vertraglichkeit von Hepar SL Forte an 553 Patienten.
book Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties.
book Uber die lipidsenkende Wirkung von Cynarin.
book Artischockenblatterextrakt: In vitro Nachweis einer Hemmwirkung auf die cholesterin-Biosynthese.
book Neue experimentelle Erkenntnisse zur Wirkung von Artischockenblatterextrakt.
book Antioxidative and protective properties of extract from leaves of the artichoke (Cynara scolymnus L,) against hydro-peroxide-induced oxidative stress incultured rat hepatocytes.
book Inhibition of Cholesterol Biosynthesis in Primary Cultured Rat Hepatocytes by Artichoke (Cynara scolymnus L.) Extracts.
book Polyphenols and flavonoids as antioxidant and hepatoprotective principles of artichoke extracts.
book Scavenging of peroxinitrite by a phenolic/peroxidase system prevents oxidative damage to DNA.
book Uber den Einfluss von cynarin auf hyperlipidamien unter besonderer Berucksichtigung des types II (hypercholesterinamie).
book Uber eine moglichkeit der kausalen Behandlung von Erkrankungen der Gallenwege mit einem Artischockenpreparat.
book Untersuchungen uber den Einfluss eines Artischockenextraktes auf die Serumlipide in Hinblick auf die Arterioskleroseprophylaxe.
book Artischocke bei Gallenwegsdyskinesien. Neue Aspekte zur Therapie mit Choleretika.
book Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase.
book Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double-blind study.
book Effect of dietary caffeic and chlorogenic acids on in vivo xenobiotic enzyme systems.
book The supression of the N-nitrosating reaction by chlorogenic acid.
book Antioxidant activity of polyphenolics in diets.
book Prufung der choleretischen Aktivitat eines pflanzlichen Cholagogums.
book Choleretic and cholesterol lowering properties of two artichoke extracts.
book Wirkungen der Cynara scolymnus-Extrakte auf die Regeneration der Rattenleber.
book Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase.
book Inhibitory effect of chlorogenic acid on methylazoxymethanolacetate-induced carcinogenesis in large intestine and liver of hamsters.
book Regressive effects of various chemopreventive agents on azoxymethane-induced aberrant crypt foci in the rat colon.


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Relief of chronic arterial obstruction using intravenous brinase. A control study.

FitzGerald DE, Frisch EP, Milliken JC
Scand J Thorac Cardiovasc Surg 1979;13(3):327-32

A therapeutic trial using placebo or the thrombolytic enzyme brinase was carried out in a group of patients with chronic arterial obstruction. The patients were observed for 3 months before receiving six intravenous infusions of either saline or brinase over a period of 2 weeks. Ankle blood pressure, Doppler ultrasound scanning, and arteriography were used to establish diagnosis in the patients. No changes were observed during the 3-month pre-observation period. After six brinase infusions, recanalization of 17 out of 27 obstructed arterial segments was recorded and the number of patent segments increased from 11 to 27. No improvement was observed in the placebo-treated patients. The differences between brinase and placebo treatment was statistically significant.



Pancreatic enzyme replacement therapy: comparative effects of conventional and enteric-coated microspheric pancreatin and acid-stable fungal enzyme preparations on steatorrhoea in chronic pancreatitis.

Schneider MU, Knoll-Ruzicka ML, Domschke S, Heptner G, Domschke W
Hepatogastroenterology 1985 Apr;32(2):97-102

The therapeutic effectiveness of a conventional (Pankreon-Granulat) and an acid-protected (Kreon) porcine pancreatic enzyme preparation, and an acid-stable fungal enzyme preparation (Nortase) in the treatment of severe pancreatogenic steatorrhoea was investigated. The study comprised 17 patients with chronic pancreatitis and exocrine pancreatic insufficiency with (A) or without (B) a previous Whipple's procedure (B II resection + partial duodenopancreatectomy). With all three enzyme preparations, a significant (p less than 0.05) reduction in the total faecal fat excretion/day was achieved. In therapy group A, this reduction was, on average, 58% for Kreon (100,000 U lipase/day), 67% for Pankreon-Granulat (360,000 U lipase/day) and 54% for Nortase (75,000 U lipase/day), the respective figures for therapy group B being 58%, 52% and 46% at identical dosages. Thus, in both groups, the effect produced by the conventional porcine pancreatic enzyme preparation and the acid-protected porcine or the acid-stable fungal enzyme preparation was largely equivalent, although the latter two preparations were administered at only 1/4 of the dosages of the former preparation. On the basis of the respective average reduction in total faecal fat excretion and average number of stools/day, it would appear that in patients with chronic pancreatitis and prior Whipple's procedure, Pankreon-Granulat should be administered for enzyme replacement while in patients with an intact upper gastrointestinal tract, Kreon should be administered, in the treatment of steatorrhoea in chronic pancreatitis.



Unique features and application of non-animal derived enzymes.

Rachman B.
Clinical Nutrition Insights 1997; 5(10)

No abstract.



Enzyme Nutrition: The Food Enzyme Concept.

Howell E.
Wayne, NJ; Aver' Publishing Group,
1985 Percival M. Nutritional Pearls (vol 35)

No abstracts found -- book review



Hepatoprotective activity of polyphenolic compounds from Cynara scolymnus against CCl4 toxicity in isolated rat hepatocytes.

Adzet T, Camarasa J, Laguna JC
J Nat Prod. 50: 612, 1987.

No abstract.



Die Artischocke - eine Heilpflanze mit Geschichte und zukunftperspektive.

Ernst E
Naturamed 10: 7, 1995.

No abstract.



Antidyspeptische und lipidsenkende Wirkungen von Artischockenextrakt. Ergebnisse klinischer Untersuchungen zur Wirksamkeit und Vertraglichkeit von Hepar SL Forte an 553 Patienten.

Fintelmann V
Z. Allg. Med. 72:48, 1996.

No abstract.



Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties.

Fintelmann V
Phytomed. 1996. Suppl 1: 50.

No abstract.



Uber die lipidsenkende Wirkung von Cynarin.

Frohlich E, Zigler W
Subsidia Medica 25 (3): 5, 1973.

No abstract.



Artischockenblatterextrakt: In vitro Nachweis einer Hemmwirkung auf die cholesterin-Biosynthese.

Gebhardt R
Med. Welt 46: 348-35-, 1995.

No abstract.



Neue experimentelle Erkenntnisse zur Wirkung von Artischockenblatterextrakt.

Gebhardt R
Z Allg. Med. 72: 20-23, 1996

No abstract.



Antioxidative and protective properties of extract from leaves of the artichoke (Cynara scolymnus L,) against hydro-peroxide-induced oxidative stress incultured rat hepatocytes.

Gebhardt R
Toxicol Appl Pharmacol 144: 279-286, 1997

No abstract.



Inhibition of Cholesterol Biosynthesis in Primary Cultured Rat Hepatocytes by Artichoke (Cynara scolymnus L.) Extracts.

Gebhart R
J Pharmacol Exp Ther 286: 3, 1998.

No abstract.



Polyphenols and flavonoids as antioxidant and hepatoprotective principles of artichoke extracts.

Gebhardt R, Fausel M, Henke B
Cell Biology and Toxicology, 1996.

No abstract.



Scavenging of peroxinitrite by a phenolic/peroxidase system prevents oxidative damage to DNA.

Grace SC, Salgo MG, Pryor WA
FEBS Letters 426(1): 24-8, 1998.

No abstract.



Uber den Einfluss von cynarin auf hyperlipidamien unter besonderer Berucksichtigung des types II (hypercholesterinamie).

Hammerl H, Kindler K, Kranzl C, Nebosis G, Pichler O, Studlar M
Wiener Med. Wschr. 41: 601-605, 1973.

No abstract.



Uber eine moglichkeit der kausalen Behandlung von Erkrankungen der Gallenwege mit einem Artischockenpreparat.

Hammerl H, Pichler O
Wiener Med. Wschr. 107 (25/26): 545, 1957.

No abstract.



Untersuchungen uber den Einfluss eines Artischockenextraktes auf die Serumlipide in Hinblick auf die Arterioskleroseprophylaxe.

Hammerl H, Pichler O
Wiener Med. Wschr. 109 (44): 853, 1959.

No abstract.



Artischocke bei Gallenwegsdyskinesien. Neue Aspekte zur Therapie mit Choleretika.

Held C
Z. Klin. Med. 47:92, 1992.

No abstract.



Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase.

Hemmerle H et al
J Medicinal Chemistry 40(2): 137-45, 1997.

No abstract.



Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double-blind study.

Kirchhoff R, Beckers C, Kirchhoff GM, Trinczek-Gartner H, Petrowicz O, Reimann HJ
Phytomedicine 1: 107, 1994.

No abstract.



Effect of dietary caffeic and chlorogenic acids on in vivo xenobiotic enzyme systems.

Kitts DD, Wijewickreme AN
Plant Foods for Human Nutrition 45(3):287-98, 1994.

No abstract.



The supression of the N-nitrosating reaction by chlorogenic acid.

Kono et al.
Biochemical Journal 312(Pt3): 947-53, 1995.

No abstract.



Antioxidant activity of polyphenolics in diets.

Kono Y et al
Biochimica et Biophysica Acta 1335(3): 335-42, 1997.

No abstract.



Prufung der choleretischen Aktivitat eines pflanzlichen Cholagogums.

Kupke D, von Sanden H, Trinczek-Gartner H, Lewin J, Blumel G, Reimann HJ:
Z. Allg. Med. (67): 1046, 1991

No abstract.



Choleretic and cholesterol lowering properties of two artichoke extracts.

Lietti A
Filoterapia 48: 153,1977.

No abstract.



Wirkungen der Cynara scolymnus-Extrakte auf die Regeneration der Rattenleber.

Maros T et al.
Arzneim-Forsch/(Drug Res) 18: 184, 1966.

No abstract.



Dicaffeoylquinic and dicaffeoyltartaric acids are selective inhibitors of human immunodeficiency virus type 1 integrase.

McDougall B, King PJ, Wu BW, Hostomsky Z, Reinecke MG, Robinson WE Jr:
Antimicrob Agents Chemother 42(1): 140-6, 1998.

No abstract.



Inhibitory effect of chlorogenic acid on methylazoxymethanolacetate-induced carcinogenesis in large intestine and liver of hamsters.

Mori H, Tanaka T, Shima H, Kuniyasu T, Takahashi M
Cancer Letters 30(1):49-54, 1986.

No abstract.



Regressive effects of various chemopreventive agents on azoxymethane-induced aberrant crypt foci in the rat colon.

Morishita Y et al
Jpn J Cancer Res 88: 815-20. 1997

No abstract.


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