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Acetaminophen and NSAID Toxicity

Avoiding Acetaminophen/NSAID Toxicity

The most effective approach to minimizing acetaminophen and NSAID toxicity would be avoiding their usage altogether and choosing alternative means for treatment of inflammation and pain (For more information, see Life Extension’s Chronic Inflammation and Chronic Pain protocols). However, because of their efficacy at reducing fever, treating inflammation, and minimizing thrombotic and cancer risk (Mills 2012), a complete cessation of NSAIDs, aspirin, or acetaminophen usage may not be suitable for everyone.

Any time acetaminophen is taken, at least 600 mg of N-acetyl cysteine should be taken along with it to help protect against liver toxicity.

Chronic users of acetaminophen or NSAIDs should have regular blood tests to monitor the health of their liver and kidneys. A simple chemistry panel can help assess both liver and kidney function, and a cystatin-C blood test helps evaluate kidney health.

If an acetaminophen overdose is suspected, call 911 or the National Poison Control Center (1-800-222-1222) immediately (NIH MedlinePlus 2012A)