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Acetaminophen and NSAID Toxicity


Abenavoli L, Capasso R, Milic N, et al. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423–32.

Abraham P. Mega dose of vitamin C augments the nephrotoxicity of paracetamol. Nephrology (Carlton). 2005;10(6):623–4.

Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. 2012 May;13(5):518-27.

AlyAM, Al-Alousi L, Salem HA. Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS PharmSciTech. 2005;6(1):E74–82.

Amar PJ and Schiff ER. Acetaminophen safety and hepatotoxicity--where do we go from here? Expert Opin Drug Saf. 2007;6(4):341–55.

Amimoto T, Matsura T, Koyama SY, et al. Acetaminophen-induced hepatic injury in mice: the role of lipid peroxidation and effects of pretreatment with coenzyme Q10 and alpha-tocopherol. Free RadicBiol Med. 1995;19(2):169–76.

Anonymous.Boswelliaserrata.Monograph.Altern Med Rev. 2008;13(2):165–7

Back M, Yin L, Ingelsson E. Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib. 2011 Nov 21. [Epub ahead of print]

Bagchi D, Ray SD, Bagchi M, et al. Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian J Exp Biol. 2002;40(6):717–26.

Bartolucci AA, Tendera M, Howard G. et al. Meta-analysis of multiple primary prevention trials of cardiovascular events using aspirin. 2011 Jun 15;107(12):1796-801.

Bennett A, Clark-Wibberley T, Stamford IF, Wright JE. Aspirin-induced gastric mucosal damage in rats: cimetidine and deglycyrrhizinatedliquorice together give greater protection than low doses of either drug alone. 1980 Feb;32(2):151.

Bessems JG and Vermeulen NP.Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol. 2001;31(1):55–138.

Brown JM, Ball JG, Hogsett A, et al. Temporal study of acetaminophen (APAP) and S-adenosyl-L-methionine (SAMe) effects on subcellular hepatic SAMe levels and methionine adenosyltransferase (MAT) expression and activity. ToxicolApplPharmacol. 2010;247(1):1–9.

Buckley N and Eddleston M. Paracetamol (acetaminophen) poisoning. ClinEvid (Online).2007;(14):1738–44.

Campos R, Garrido A, Guerra R, et al. Silybindihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 1989;55(5):417–9.

Cekmen M, Ilbey YO, Ozbek E, et al. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food ChemToxicol. 2009;47(7):1480–4.

Chen JT, Pucino F, Resman-Targoff BH. Celecoxib versus a Non-Selective NSAID Plus Proton-Pump Inhibitor: What Are the Considerations? J Pain Palliat Care Pharmacother. 2006;20(4):11-32.

Cho CH, Luk CT, Ogle CW. The membrane-stabilizing action of zinc carnosine (Z-103) in stress-induced gastric ulceration in rats. Life Sci. 1991;49(23):L189-94.

Conaghan PG. A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatol Int. 2012;32(6):1491–502.

Craig DGN, Ford AC, Hayes PC, et al. Systematic review: prognostic tests of paracetamol-induced acute liver failure. Aliment PharmacolTher. 2010;31(10):1064–76.

Dal Pan GJ. Acetaminophen: Background and Overview. 6/2009. Available at: Accessed 7/18/2012.

Das SK, Das V, Gulati AK, Singh VP.Deglycyrrhizinatedliquorice in aphthous ulcers. 1989 Oct;37(10):647.

De Berardis G, Lucisano G, D'Ettorre A, et al. Association of aspirin use with major bleeding in patients with and without diabetes. 2012 Jun 6;307(21):2286-94.

Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. 2000 Nov 11;321(7270):1183-7.

Doi H and Horie T. Salicylic acid-induced hepatotoxicity triggered by oxidative stress. 2010 Feb 12;183(3):363-8.

Dolcet X, Llobet D, Pallares J, et al. NF-kB in development and progression of human cancer. 2005 May;446(5):475-82.

Ejaz P, Bhojani K, Joshi VR. NSAIDs and kidney.J Assoc Physicians India. 2004 Aug;52:632-40.

Ferner RE, Dear JW, Bateman DN. Management of paracetamol poisoning.BMJ. 2011;342:d2218.

Firdous AP, Sindhu ER, Kuttan R. Hepato-protective potential of carotenoid meso-zeaxanthin against paracetamol, CCl4 and ethanol induced toxicity. Indian J Exp Biol. 2011;49(1):44–9.

Fitzgerald GA and Patrono C.The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001;345(6):433–42.

Fouad AA and Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ. ToxicolPharmacol. 2012;33(2):158–67.

Furuta S, Toyama S, Miwa M, et al. Residence time of polaprezinc (zinc L-carnosine complex) in the rat stomach and adhesiveness to ulcerous sites. 1995 Apr;67(4):271-8.

García Rodríguez LA, Hernández-Díaz S, and de Abajo FJ. Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies. 2001 Nov;52(5):563-71.

Ghabril M, Chalasani N, Björnsson E. Drug-induced liver injury: a clinical update. CurrOpinGastroenterol. 2010;26(3):222–6.

Girish C, Koner BC, Jayanthi S, et al. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. FundamClinPharmacol. 2009;23(6):735–45.

Goldman L. Goldman's Cecil Medicine, 24th ed. Copyright © 2011 Saunders, An Imprint of Elsevier. Available at: Accessed 7/17/2012.

Goldstein JL, Howard KB, Walton SM, et al. Impact of adherence to concomitant gastroprotective therapy on nonsteroidal-related gastroduodenal ulcer complications. ClinGastroenterolHepatol. 2006;4(11):1337–45.

Gooch K, Culleton BF, Manns BJ, et al. NSAID use and progression of chronic kidney disease. 2007 Mar;120(3):280.e1-7.

Harper JM, Salmon AB, Chang Y, et al. Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev. 2006;127(8):687–94.

Harvard Medical School. 12 things you should know about pain relievers. 2006. Available at: Accessed 7/17/2012.

Hattori A, Yamada N, Nishikawa T, et al. Protective effect of ajoene on acetaminophen-induced hepatic injury in mice. BiosciBiotechnolBiochem. 2001;65(11):2555–7.

Hau DKP, Wong RSM, Cheng GYM, et al. Novel use of silymarin as delayed therapy for acetaminophen-induced acute hepatic injury.ForschKomplementmed. 2010;17(4):209–13.

Hinson JA, Roberts DW, James LP. Mechanisms of acetaminophen-induced liver necrosis.HandbExpPharmacol. 2010;(196):369–405.

Hwang J. Diets with corn oil and/or low protein increase acute acetaminophen hepatotoxicity compared to diets with beef tallow in a rat model. Nutr Res Pract. 2009;3(2):95–101.

Ilbey YO, Ozbek E, Cekmen M, et al. Melatonin prevents acetaminophen-induced nephrotoxicity in rats. IntUrolNephrol. 2009;41(3):695–702.

Iyanda A, Anetor J, Adeniyi F, et al. Effect of methionine on hepatic indices in male Wistar rat dosed to acetaminophen formulation. African Journal of Pharmacy and Pharmacology. 2010;4(9):653–7.

James LP, Mayeux PR. Hinson JA. Acetaminophen-induced hepatotoxicity. 2003 Dec;31(12):1499-506.

Jamshidzadeh A, Baghban M, Azarpira N, et al. Effects of tomato extract on oxidative stress induced toxicity in different organs of rats. Food ChemToxicol. 2008;46(12):3612–5.

Jeng KC, et al. Collagen induces cytokine production by synovial fluid mononuclear cells in rheumatoid arthritis. ImmunolLett 1995 Feb;45(1-2):13-7.

Johnson JB, John S, Laub DR. Pretreatment with alternate day modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates. Med Hypotheses. 2009;72(4):381–2.

Jonker D, Lee VS, Hargreaves RJ, et al. Comparison of the effects of ascorbylpalmitate and L-ascorbic acid on paracetamol-induced hepatotoxicity in the mouse.Toxicology. 1988;52(3):287–95.

Kanno SI, Tomizawa A, Hiura T, et al. Melatonin protects on toxicity by acetaminophen but not on pharmacological effects in mice. Biol Pharm Bull. 2006;29(3):472–6.

Kheradpezhouh E, Panjehshahin MR, Miri R, et al. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine. European Journal of Pharmacology. 2010;628(1-3):274–81.

Kobrinsky NL, Hartfield D, Horner H, et al. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest. 1996;14(3):202–10.

Kristensen DM, Lesné L, Le Fol V, et al. Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis. Int J Androl. 2012;35(3):377–84.

Kristensen, DM, Hass, U, Lesné, L, et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Hum. Reprod. 2011;26(1):235–44

Laine L, Kivitz AJ, Bello AE, et al. Double-blind randomized trials of single-tablet ibuprofen/high-dose famotidine vs. ibuprofen alone for reduction of gastric and duodenal ulcers.Am J Gastroenterol. 2012;107(3):379–86.

Lanas A. Gastrointestinal bleeding associated with low-dose aspirin use: relevance and management in clinical practice. 2011 Jan;10(1):45-54.

Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42(6):1364–72.

Li H, Hortmann M, Daiber A, et al. Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases. 2008 Sep;326(3):745-53.

Mahmood A, FitzGerald AJ, Marchbank T, et al. Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes. Gut. 2007;56(2):168–75.

Maity P, Bindu S, Dey S, et al. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. 2009 Apr;46(3):314-23.

Masubuchi Y, Sugiyama S, Horie T. Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury. ChemBiol Interact. 2009;179(2-3):273–9.

Matsukura T, Tanaka H. Applicability of zinc complex of L-carnosine for medical use. 2000 Jul;65(7):817-23.

Matsura T, Nishida T, Togawa A, et al. Mechanisms of protection by melatonin against acetaminophen-induced liver injury in mice. J Pineal Res. 2006;41(3):211–9.

Mayo Clinic.Arthritis. Updated 1/22/2011. Available at: Accessed 7/17/2012.

Mills EJ, Wu P, Alberton M, et al. Low-dose Aspirin and Cancer Mortality: A Meta-analysis of Randomized Trials. Am J Med. 2012;125(6):560–7.

Moodley I. Review of the cardiovascular safety of COXIBs compared to NSAIDS. 2008 Mar-Apr;19(2):102-7.

Moyer AM, Fridley BL, Jenkins GD, et al. Acetaminophen-NAPQI Hepatotoxicity: A Cell Line Model System Genome-Wide Association Study. Toxicol Sci. 2011;120(1):33–41.

Nagalekshmi R, Menon A, Chandrasekharan DK, et al. Hepatoprotective activity of Andrographispaniculata and Swertiachirayita. Food ChemToxicol. 2011;49(12):3367–73.

NIH MedlinePlus. Aspirin overdose. Available at: Accessed 7/20/2012A.

O’Connor N, Dargan PI, and Jones AL. Hepatocellular damage from non-steroidal anti-inflammatory drugs. 2003 Nov;96(11):787-91.

Omatsu T, Naito Y, Handa O, et al. Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury. J Gastroenterol. 2010;45(7):692–702.

Oz HS and Chen TS.Green-tea polyphenols downregulate cyclooxygenase and Bcl-2 activity in acetaminophen-induced hepatotoxicity. Dig Dis Sci. 2008;53(11):2980–8.

Oz HS, McClain CJ, Nagasawa HT, et al. Diverse antioxidants protect against acetaminophen hepatotoxicity. J BiochemMolToxicol. 2004;18(6):361–8.

Ozkaya O, Genc G, Bek K, and Sullu Y.A case of acetaminophen (paracetamol) causing renal failure without liver damage in a child and review of literature.Ren Fail. 2010;32(9):1125–7

Patel V, Fisher M, Voelker M, et al. Gastrointestinal effects of the addition of ascorbic Acid to aspirin. 2012 Jul;12(6):476-84.

Peterson FJ, Lindemann NJ, Duquette PH, et al. Potentiation of acute acetaminophen lethality by selenium and vitamin E deficiency in mice. J Nutr. 1992;122(1):74–81.

Peterson K, McDonagh M, Thakurta S, et al. Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report. National Institute of Health (NIH) PubMed Health. Bethesda (MD): National Library of Medicine (US). Nov. 2010.

Peura DA. Gastrointestinal safety and tolerability of nonselective nonsteroidal anti-inflammatory agents and cyclooxygenase-2-selective inhibitors. Cleve Clin J Med. 2002;69Suppl 1:SI31–9.

Ray SD, Kumar MA, Bagchi D. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. BiochemBiophys. 1999;369(1):42–58.

Reagan-Shaw S, Nihal M, and Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2007;22(3):659–61

Reiss AB, Anwar F, Chan ES, et al. Disruption of cholesterol efflux by coxib medications and inflammatory processes: link to increased cardiovascular risk. 2009 Aug;57(6):695-702.

Roth SH. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety. ClinInterv Aging. 2011;6:125–31.

Rothwell PM, Fowkes FG, Belch JF, Ogawa H, Warlow CP, Meade TW. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011 Jan 1;377(9759):31-41.

Sancar M, Hantash T, Okuyan B, et al. Comparative effectiveness of Glycyrrhizaglabra vs. omeprazole and misoprostol for the treatment of aspirin-induced gastric ulcers. African Journal of Pharmacy and Pharmacology. 2009;3(12):615–20.

Sandoval-Acuña C, Lopez-Alarcón C, Aliaga ME, et al. Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. 2012 Jul 30;199(1):18-28.

Schnell RC, Park KS, Davies MH, et al. Protective effects of selenium on acetaminophen-induced hepatotoxicity in the rat.ToxicolApplPharmacol. 1988;95(1):1–11.

Schrör K. Pharmacology and cellular/molecular mechanisms of action of aspirin and non-aspirin NSAIDs incolorectal cancer. 2011 Aug;25(4-5):473-84.

Sener G, Omurtag GZ, Sehirli O, et al. Protective effects of ginkgo biloba against acetaminophen-induced toxicity in mice.Mol Cell Biochem. 2006a;283(1-2):39–45.

Sener G, Toklu HZ, Sehirli AO, et al. Protective effects of resveratrol against acetaminophen-induced toxicity in mice.Hepatol Res. 2006b;35(1):62–8.

Sharma M. Chronic Acetaminophen Toxicity. 10/26/2009. Available at: Accessed 7/18/2011.

Sindhu ER, Firdous AP, Preethi KC, et al. Carotenoid lutein protects rats from paracetamol-, carbon tetrachloride- and ethanol-induced hepatic damage. J Pharm Pharmacol. 2010;62(8):1054–60.

Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am. J. Med. 1998;105(1B):31S–38S

Singh S, Khajuria A, Taneja, SC, et al. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswelliaserrata, in rats.Phytomedicine. 2008;15(6-7):408–15

Sivalingam N, Basivireddy J, Balasubramanian KA, et al. Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. 2008 Jul;82(7):471-81.

Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319(24):1557–62.

Stark LA, Reid K, Sansom OJ, et al. Aspirin activates the NF-kappaBsignalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. 2007 May;28(5):968-76. Epub 2006 Nov 28.

Sumioka I, Matsura T, Yamada K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice.European Journal of Pharmacology. 2001;433(2-3):177–85.

Takahashi T, Takahashi T, et al. Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral RadiolEndod 1998 Feb;85(2):135-41.

Terneus MV, Brown JM, Carpenter AB, et al. Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose. Toxicology. 2008;244(1):25–34.

Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. 2002 Feb 20;94(4):252-66.

Toussaint K, Yang XC, Zielinski MA, et al. What do we (not) know about how paracetamol (acetaminophen) works? J Clin Pharm Ther. 2010;35(6):617–38.

Trelle S, Reichenbach S, Wandal S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. BMJ. 2011;342:c7086.

van Leeuwen JS, Unlü B, Vermeulen NP, et al. Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. 2012 Mar;26(2):197-205. Epub 2011 Nov 26.

Van Mil AH, and Janssens AR. [Acetaminophen use by chronic alcohol abusers: a therapeutic dose may be too much for the liver]. 2001 Sep 29;145(39):1873-6.

Vestergaard P, Hermann P, Jensen JEB, et al. Effects of paracetamol, non-steroidal anti-inflammatory drugs, acetylsalicylic acid, and opioids on bone mineral density and risk of fracture: results of the Danish Osteoporosis Prevention Study (DOPS). Osteoporos Int. 2012;23(4):1255–65.

Visen PK, Shukla B, Patnaik GK, et al. Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol. 1993;40(2):131–6.

Vonkeman HE and van de Laar MAFJ.Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention. Semin Arthritis Rheum. 2010;39(4):294–312.

Wang EJ, Li Y, Lin M, et al. Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice. ToxicolApplPharmacol. 1996;136(1):146–54.

Watanabe T, Tanigawa T, Nadatani Y, et al. Mitochondrial disorders in NSAIDs-induced small bowel injury. 2011 Mar;48(2):117-21. Epub 2011 Feb 26.

Watkins PB, Kaplowitz N, Slattery JT, et al. Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial. JAMA. 2006;296(1):87–93.

Weir MR. Renal effects of nonselective NSAIDs and coxibs. Cleve Clin J Med. 2002;69Suppl 1:SI53-8.

Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhizaglabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009 Sep 7;125(2):218-23. Epub 2009 Jul 14.

Wolf MS, King J, Jacobson K, et al. Risk of Unintentional Overdose with Non-Prescription Acetaminophen Products. J Gen Intern Med. 2012 May 26. [Epub ahead of print]

Yalçin S, Bilgili A, Onbasilar I, et al. Synergistic action of sodium selenite and N-acetylcysteine in acetaminophen-induced liver damage. Hum ExpToxicol. 2008;27(5):425–9.

Zahra T, Butt SA, Arshad, M. Effects of Beta Carotene on Liver Enzymes in Acetaminophen Treated Rats. Journal of Rawalpindi Medical College (JRMC). 2010;14(1):7–10.

Zhao C and Shichi H. Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.J OculPharmacolTher. 1998;14(4):345–55.

Zhao L and Pickering G. Paracetamol metabolism and related genetic differences. Drug Metab Rev. 2011;43(1):41–52.