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Breast Cancer

Types of Standard Screening Techniques

In order to detect breast cancer at its earliest, most treatable stage, the importance of regular monthly breast self-exams, and yearly clinical breast exams, cannot be overemphasized. Mammography, sonography, contrasting magnetic resonance imaging (MRI) and digital infrared thermal imaging are all viable diagnostic tools, which will be discussed later in this article. Having regular breast-cancer screening exams is considered the single most effective way to lower the risk of dying from breast cancer.

"Early-stage" invasive cancer is considered very treatable because the tumor is relatively small and the cancer cells have not spread to the lymph nodes. However, when a tumor has become very large or has spread to other organs (such as the liver, lungs, or bones), it is considered "advanced-stage" invasive cancer and is far less treatable.

Breast cancer was thought to grow in an orderly progression from a small tumor in the breast tissue to a larger tumor. The cancer was believed to then travel from the breast into the adjacent lymph nodes, spreading throughout the distant nodes and finally metastasizing in other areas of the body. However, a growing body of research now contends that cancer cells are capable of traveling from the breast throughout the blood and lymphatic systems very early in the course of the disease. This strengthens the rationale for early detection and treatment.

Breast Self-Exam

A breast self-exam provides an opportunity to detect tumors that may develop in the time between yearly clinical breast exams. To increase a woman's chances of detecting a small tumor at a time when it may be more responsive to treatment, a breast self-exam should be performed monthly, usually 2-3 days after menstruation. For women with irregular periods, it is important to remember to perform a monthly exam on the same day each month. Keep in mind that prior to menstruation or during pregnancy, breasts may be somewhat lumpy or more tender than usual.

By performing self-exams once a month, women can become familiar with the normal appearance and "feel" of their breasts, increasing the likelihood of recognizing changes such as thickening, lumps, or spontaneous nipple discharge. Because breast tissue normally has a bumpy texture, it may feel lumpy. However, there can be a great deal of individual variation. If a breast has lumpiness throughout, then it is probably just the normal contours of the breast tissue and in most cases is no cause to worry. Dominant lumps are firmer than the rest of the breast and are of more concern. When a dominant lump is found, there is an increased risk that it may be cancer, even though cysts and fibroadenomas can cause similar lumps. Any time a woman discovers a lump that feels dominant, it should be checked by a medical professional.

How to Do Breast Self-Exam

  1. Lie down. Flatten your right breast by placing a pillow or towel under your right shoulder. Place your right arm behind your head. Examine your right breast with your left hand.
  2. Use the pads, not the tips, of the middle three fingers on your left hand. With fingers flat, press gently using a circular, rubbing motion and feel for lumps. In small, dime-sized circles without lifting the fingers, start at the outermost top edge of your breast and spiral in toward the nipple.
  3. Press firmly enough to feel the different breast tissues, using three different pressures. First, light pressure to just move the skin without jostling the tissue beneath, then medium pressure pressing midway into the tissue, and finally deep pressure to probe more deeply down to the ribs or to the point just short of discomfort.
  4. Completely feel all of the breast and chest area up under your armpit, up to the collarbone, and all the way over to your shoulder to cover breast tissue that extends toward the shoulder.
  5. Gently squeeze both nipples and look for discharge.

After you have completely examined your right breast, examine your left breast using the same method with your right hand. You may want to examine your breasts or do an extra exam while showering. It's easy to slide soapy hands over your skin and to feel anything unusual. You should also check your breasts in a mirror, looking for any change in size or contour, dimpling of the skin, or spontaneous nipple discharge.

Clinical Breast Exam

Clinical breast exams are physical examinations to check the appearance and "feel" of the breasts for signs of lumps. A physician, nurse practitioner, or other trained medical staff person will examine the breasts, both when the woman is sitting upright and when she is lying down.

Clinical breast exams are an important part of breast cancer screening. For younger women, clinical breast exam may have an advantage over mammography; mammography images can be more difficult to read in some younger women because of their dense breast tissue. For this reason, clinical breast exams are generally started much earlier than mammograms.

Mammography

Mammography is an x-ray technique used to locate small or indistinctly shaped breast lumps that may not be felt during an exam. A mammogram takes about 15 minutes and consists of compressing each breast individually between two plates to makean x-ray image. Afterwards, a radiologist will read the film and look for any signs of abnormal tissue.

X-ray images appear in gradations of black, gray, and white depending on the density or hardness of the tissue. For example, since bone is especially dense, it appears white on an x-ray, while fat appears dark gray. Cancerous tumors and some other noncancerous abnormalities appear as a lighter shade of gray. Unfortunately, this may pose a problem because normal, dense breast tissue may appear light gray on a mammogram. Breast density changes with age. Younger women have proportionately more breast tissue than fat and therefore denser breasts, making mammograms difficult to interpret. In older women's breasts, density dissipates with age, leaving breasts that are composed mostly of fat. A mammogram that shows the light gray patch of a tumor or lesion surrounded by the dark gray image of fat tissue is most easily recognized.

Cysts and fibroadenomas appear as circular or oval patches with stark outer edges on x-rays, allowing a radiologist to identify where the border of the benign abnormal tissue ends and the surrounding normal tissue begins. On an x-ray, the core cancerous cells appear as a light patch, while the cancer cells that invade the surrounding tissue create a fuzzy or spiky appearance along the outer edge (called "spiculated"), producing an image with no clear borders.

There is growing controversy regarding the safety and efficacy of mammography. The National Cancer Institute clearly states on their website “Being exposed to radiation is a risk factor for breast cancer” (National Cancer Institute 2003). Further, both low-filtered (30 kVp) x-rays and mammography x-rays have mutagenic effect on mammalian cells. A re-evaluation of the risk assessment of mammography, especially for familial predisposed women is recommended. People with known increased risk of breast cancer, particularly those with a familial predisposition, are advised to be cautious and avoid early and frequent mammography exposure. Alternative examination methods should be considered for women with an inherited increased risk of breast cancer (Frankenberg-Schwager et al. 2002).

There is evidence that high-quality mammography may reduce breast cancer mortality in women aged 50 to 69. In fact, the risk of radiation-induced breast cancer decreases with increasing age at radiation exposure (Jung 2001). There has been difficulty in establishing the benefit of screening mammography in younger women. This difficulty has been attributed to both the technical limitations introduced by younger women’s dense breast tissue and to differences in breast cancer biology in younger women. Equally, women with inherited increased risk for breast cancer may gain no benefits from early screening.

The false positive rate ranges from 2.6% to 15.9% (Elmore et al. 2002). False positives usually result in additional diagnostic tests, which can include an additional x-ray examination, or a biopsy, which is the removal of a small portion of breast tissue for microscopic examination. A portion of the population’s mammograms are misread as false negatives. A false negative mammogram occurs when the mammogram is read as “normal” or “negative” although a malignancy is present. Screening mammograms from a population-based screening registry estimated a missed detectable cancer rate of 29% (Yankaskas et al. 2001). Other studies report a missed detectable cancer rate by mammograms of approximately 12% to 37% (Woolf 2001).

Regardless of the high rates of false-positives and false-negatives, x-ray mammography is still considered the gold standard of breast cancer screening since it can detect tumors at an early stage when they are small and responsive to treatment. Most physicians recommend annual mammograms for women over 40, and for those at high risk with a family history of breast cancer.

Ultrasound

Ultrasound, also known as sonography, is an imaging method that utilizes very-high frequency sound waves to produce a picture that outlines the breast without exposure to ionizing radiation. During a sonogram, (also known as echogram) sound waves are transmitted through the breast. Depending on the nature of the breast tissue, the sound waves are reflected back or are transmitted through the tissue being examined. The pictures generated are the results of such echoes; they are picked up and translated by a computer resulting in the ultrasound image. Breast ultrasonography can be used to evaluate breast problems found during a mammogram or a physical exam.

Ultrasound is useful for some breast masses. It can be used to determine if a breast mass is solid (and more likely to be malignant) or if it is cystic and filled with fluid (and more likely to be benign). The ultrasound facilitates analysis by enabling the radiologist to guide a needle to biopsy a solid mass or to remove fluid if it is a cystic fluid-filled mass. The limitation of both mammography and ultrasound is that both have diagnostic features, which depend primarily on structural distinction and anatomical variation of a tumor from the surrounding breast tissue. These limitations make distinguishing benign microcalcifications from malignancies nearly impossible.

MRI

Magnetic Resonance Imaging (MRI) of the breast, also known as a breast MRI, is an imaging method consisting of a high field (1.5 Tesla) magnet with dedicated breast coils linked to a computer. The most useful MRI breast examination combines a contrast material, known as Gadolinium DTPA, magnetization, and radio waves to provide detailed pictures of an area inside the breast by a computer without the use of radiation. Every MRI produces hundreds of images of the breast from side-to-side, top-to-bottom, and front-to-back.

MRI is the most sensitive imaging modality for detection of breast cancer (Kuhl et al. 2000; Warner et al. 2001). Unfortunately, an MRI cannot always accurately distinguish between cancer and benign (noncancerous) breast conditions. Like ultrasound, MRI cannot detect microcalcifications. MRI is, however, effective in evaluating dense breast tissue and may be useful in screening younger women at high risk for breast cancer due to a predisposing family history of breast cancer.

MRI can be used to evaluate women who have had augmentation or breast enlargement surgery using implants. In such context, MRI is an excellent tool for imaging the augmented breast, including the breast implants itself, and the surrounding tissue, since abnormalities or signs of breast cancer are sometimes obscured by the implant. In contrast, the x-rays used in mammography are not able to penetrate silicone or saline implants sufficiently to image the overlying or underlying breast tissue. Compared to mammography or ultrasound, MRI is more accurate in women with augmented breasts.

Thermography

Digital Infrared Thermal Imaging, also known as thermography, is a painless, non-invasive diagnostic technique, which does not involve any radiation exposure. This technology at one time appeared promising but lost favor about 20 years ago. However, with new ultra-sensitive high-resolution digital infrared devices, its efficacy has been improved. Infrared imaging software utilizes high precision pixel temperature measurements which can detect minute temperature variations related to blood flow and can demonstrate abnormal blood flow patterns associated with the initiation and progression of a chaotic tumor vasculature (blood flow system). Angiogenesis is a key factor that facilitates the growth of cancer and it is this biological feature of cancer on which thermography is based. Due to thermography’s sensitivity to blood flow and metabolic changes, it can detect tumors at a smaller size than mammography.

Unfortunately, there are no studies involving the detection of breast cancer that compare the accuracy of Digital Infrared Thermal Imaging to that of mammography, ultrasound, and MRI. However, studies have been conducted to evaluate the accuracy of mammography versus ultrasound versus MRI. In a study that screened 192 women at high risk for breast cancer, cancer was detected in nine patients. Mammography and ultrasound detected 6 of the nine cases of cancer whereas MRI detected all nine cases of breast cancer (Kuhl et al. 2000).

Another study comparing the accuracy of these three modalities screened 196 women at high risk for hereditary breast cancer and detected a total of six cases of invasive breast cancer. Mammography detected 2 of the 6 cases, ultrasound detected 3 of the 6, and MRI detected all 6 cases(Warner et al. 2001).

High-Risk Screening

Regular screening is especially important for women who are at high risk of breast cancer. A woman can be placed in a high-risk category if she possesses either a single factor that greatly increases her risk or a combination of lesser factors that together increase her risk.

Single factors that can place a woman in a high-risk category include a personal history of breast cancer, carcinoma in situ, atypical hyperplasia, and exposure to high doses of ionizing radiation in childhood or young adulthood (for instance, for treatment of Hodgkin's disease) (Hancock et al. 1993; USPSTF 1996; Harris et al. 1997). A family history of breast cancer, especially in a mother, sister, or daughter, or a particular genetic mutation can also place a woman at high risk of breast cancer. In addition, research on genetic markers for breast-cancer risk has pinpointed a number of genes, two of which, BRCA1 and BRCA2, are associated with a markedly elevated risk of breast and ovarian cancer. As many as 60-80% of women with mutations in either of these two genes may develop breast cancer in their lifetimes (Alberg et al. 1997; Struewing et al. 1997; Whittemore 1997).

There are also several moderate risk factors for breast cancer, which occurring together can place a woman at high risk. They include having a first period (menarche) before age 12, not bearing a child, and having a first child after age 30. It is recommended that women at high risk for breast cancer have annual clinical breast examinations more frequently than women at average risk.