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The goal of therapy is to strengthen pancreatic function, impede cancer growth and spread, and reduce the severity of symptoms. Various nutritional supplements outlined in this chapter have been shown to help pancreatic cancer patients by slowing disease progression or increasing quality of life.

Guidelines for Reducing Pancreatic Cancer Risk

  • Stop smoking and stop drinking alcohol.
  • Avoid or reduce exposure to toxic chemicals and petroleum products.
  • Maintain a healthy body weight.
  • Reduce dietary intake of fried foods, red meat, meat products, and dairy.
  • Increase intake of fresh fruit and vegetables, fiber, minerals, and vitamins.
  • Reduce sugar consumption (glycemic load).
  • Increase physical activity.
  • Maintain a diet suitable for diabetics that restricts simple carbohydrates such as sugar and emphasizes complex carbohydrates (fibers) and proteins (refer to the Diabetes protocol). Protein supplements such as soy and essential fatty acids such as fish oils will help by altering the dietary intake ratio of carbohydrates, proteins, and fats.

If pancreatic cancer patients are to improve their odds of achieving a remission or long-term survival, they should attempt to integrate into their conventional therapy as many of the following dietary changes and supplements as possible, but only under a physician’s supervision.

Primary Supplements:

  • Fish oil: 700 – 4200 mg of EPA, 500 – 2000 mg of DHA daily with food
  • Curcumin: 2400 mg daily (As highly absorbed BCM-95®)
  • Soy extract: providing approximately 500 mg of genistein daily
  • Perillyl alcohol: 2000 mg, four times daily
  • Vitamin A (preformed): 3000 IU daily, with food
  • Vitamin C: 1000 – 5000 mg daily in 4 divided doses
  • Vitamin E: 400 IU daily of natural alpha tocopherol vitamin E along with 200 mg of gamma tocopherol and about 380 mg of mixed tocotrienols
  • Vitamin D3: 5000 – 8000 IU daily with food. Blood levels of vitamin D3 should be regularly monitored to achieve a blood level of 50-80 ng/mL.
  • R-Lipoic Acid: 300 mg twice daily
  • Melatonin: 10 – 40 mg at bedtime
  • PSK: 3 g daily
  • Multivitamin/multi-mineral formula without copper: follow label directions

Life Extension also suggests a low-dose aspirin (81 mg) daily.

Secondary Supplements:

Innovative Drug Strategies

The following should be used only under a physician’s supervision:

  • Metformin: 500 mg three times daily before meals
  • Chloroquine
  • Celecoxib
  • Zileuton
  • Pancreatic enzymes (by prescription)—1000 to 10,000 U lipase per kg of body weight per meal (Schibli 2002). Delayed-release preparations (capsules containing enteric-coated microspheres, such as Creon®) are reportedly less susceptible to acid inactivation.
  • Antacids or a histamine H2-receptor antagonist (cimetidine, Tagamet®) have been used to decrease the inactivation of pancreatic enzyme activity.
  • Ukrain (NSC-631570). Ukrain is supplied as a solution ready for injection. A Ukrain therapy cycle consists of 10 mg taken intravenously every other day for 20 days. A vitamin C cycle is added to the Ukrain cycle, 3 grams taken intravenously every other day, and 2.4 grams taken orally in three divided doses on the same days, for 20 days (Zemskov 2002).

For information on how to obtain Ukrain, please contact:

Ukrainian Anticancer Institute
Velyka Zhytomyrska 17/28,
Kiev, Ukraine
Tel: (+380) 44 27237191
Fax: (+380) 44 2723791

For More Information

Pancreatic cancer is usually associated with weight loss (catabolic wasting) and pain. The following Life Extension protocols may be useful in designing a program that will address specific needs: