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Life Extension Suggestions

Depression is a multifactorial condition, and efficient relief often requires addressing multiple neurochemical and metabolic imbalances that may underlie mood disturbances. The nutrients listed in this protocol are categorized according to their evidence-based mechanisms of action in brain health and mood regulation.

Many of these suggestions may serve as adjuvants to conventional therapies for depression. Always consult a qualified healthcare professional before combining any supplements with an antidepressant medication.

Broad-Range Nervous System Effects

  • Fish oil (with olive polyphenols): 1400 mg EPA and 1000 mg DHA daily
  • Magnesium L-Threonate: 2000 mg daily (supplying 144 mg elemental magnesium)

Supporting Neurotransmitter Synthesis

Supporting Methylation Reactions

Supporting Blood Sugar Regulation

Antioxidant Effects

Supporting Mitochondrial Health

Hormone Restoration

Men and women with depression should consider restoring their hormone concentrations to youthful levels with the use of natural bioidentical hormones. More information is available in the Male Hormone Restoration and Female Hormone Restoration protocols. A natural, over-the-counter hormone men and women should consider optimizing is:

  • DHEA: 15 – 50 mg daily for women or 25 – 75 mg daily for men

In addition, thyroid hormone irregularities may contribute to depression. Therefore, those with known or suspected thyroid dysfunction should refer to the Thyroid Regulation protocol.

Miscellaneous Mechanisms of Relief

In addition, the following blood testing resources may be helpful: