Whole Body Health Sale

Chronic Inflammation

References

Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., and Sethi, G. Inflammation and cancer: how hot is the link? Biochem. Pharmacol. 2006;72(11):1605–1621

Ahmadi N, Eshaghian S, Huizenga R, et al. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med. 2011;124(10):978-82.

Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee—a double-blind prospective randomized study. Clin Rheumatol. 2004 Oct;23(5):410-5

Alvarez-Lario, B., and Macarrón-Vicente, J. Is there anything good in uric acid? QJM. 2011;

Anderson, G. L., Limacher, M., Assaf, A. R., et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004;291(14):1701–1712

Andrade-Cetto A, Vazquez RC. Gluconeogenesis inhibition and phytochemical composition of two Cecropia species. J Ethnopharmacol. 2010 Jul 6;130(1):93-7.

Araki, S., Dobashi, K., Kubo, K., Kawagoe, R., Yamamoto, Y., and Shirahata, A. N-acetylcysteine inhibits induction of nitric oxide synthase in 3T3-L1 adipocytes. J. UOEH. 2007;29(4):417–429

Arnson, Y., Shoenfeld, Y., and Amital, H. Effects of tobacco smoke on immunity, inflammation and autoimmunity. J. Autoimmun. 2010;34(3):J258–65

Au-Yeung, K. K. W., Yip, J. C. W., Siow, Y. L., and O, K. Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages. Can. J. Physiol. Pharmacol. 2006;84(1):141–147

Awad, A. B., Alappat, L., and Valerio, M. Vitamin d and metabolic syndrome risk factors: evidence and mechanisms. Crit Rev Food Sci Nutr. 2012;52(2):103–112

Bahorun, T., Luximon-Ramma, A., Gunness, T. K., et al. Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology. 2010;278(1):68–74

Balkwill, F. Tumour necrosis factor and cancer. Nat. Rev. Cancer. 2009;9(5):361–371

Bao, B., Prasad, A. S., Beck, F. W. J., et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. American Journal of Clinical Nutrition. 2010;91(6):1634–1641

Basta G, Schmidt AM, De Caterina R. Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes. Cardiovasc Res. 2004 Sep 1;63(4):582-92.

Bastard, J.-P., Maachi, M., Lagathu, C., et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 2006;17(1):4–12

Bauerly K et al. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One. 2011;6(7):e21779. Epub 2011 Jul 21.

Bendsen, N. T., Stender, S., Szecsi, P. B., et al. Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women. The Journal of Lipid Research. 2011;52(10):1821–1828

Bengmark, S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr. 2006;30(1):45–51

Boldyrev AA et al. [Carnosine: endogenous physiological corrector of antioxidative system activity]. Usp Fiziol Nauk. 2007 Jul-Sep;38(3):57-71.

Boswellia serrata. Altern Med Rev. 2008;13(2):165–167

Bromelain. Monograph. Altern Med Rev. 2010;15(4):361–368

Bruunsgaard, H. Physical activity and modulation of systemic low-level inflammation. J Leukoc Biol. 2005;78(4):819–835

Bu, D.-X., Griffin, G., and Lichtman, A. H. Mechanisms for the anti-inflammatory effects of statins. Curr. Opin. Lipidol. 2011;22(3):165–170

Bulcão, C., Giuffrida, F. M. A., Ribeiro-Filho, F. F., and Ferreira, S. R. G. Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity? Braz. J. Med. Biol. Res. 2007;40(2):229–235

Buler, M., Aatsinki, S.-M., Skoumal, R., et al. Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver: INDUCTION OF INTERLEUKIN 1 RECEPTOR ANTAGONIST. J Biol Chem. 2012;287(3):1847–1860

Calder, P. C. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr. 2006;83(6 Suppl):1505S–1519S

Cao, J. J. Effects of obesity on bone metabolism. J Orthop Surg Res. 2011;6:30

Cavicchia, P. P., Steck, S. E., Hurley, T. G., et al. A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein. Journal of Nutrition. 2009;139(12):2365–2372

Centers for Disease Control and Prevention. FASTSTATS - Leading Causes of Death. cdc.gov. 2011; Available at: http://www.cdc.gov/NCHS/fastats/Default.htm [Accessed December 23, 2011].

Chacko, S., Song, Y., Nathan, L., and Tinker, L. Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women. Diabetes. 2010;

Chainani-Wu, N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Altern Complement Med. 2003;9(1):161–168

Chavali, S. R., Zhong, W. W., Utsunomiya, T., and Forse, R. A. Decreased production of interleukin-1-beta, prostaglandin-E2 and thromboxane-B2, and elevated levels of interleukin-6 and -10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with Quil-A saponin. Int. Arch. Allergy Immunol. 1997;114(2):153–160

Chen, Y.-G., Xu, F., Zhang, Y., et al. Effect of aspirin plus clopidogrel on inflammatory markers in patients with non-ST-segment elevation acute coronary syndrome. Chin. Med. J. 2006;119(1):32–36

Clarke, J. O., and Mullin, G. E. A review of complementary and alternative approaches to immunomodulation. Nutrition in Clinical Practice. 2008;23(1):49–62

Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., and Costello, E. J. Cumulative depression episodes predict later C-reactive protein levels: a prospective analysis. Biol. Psychiatry. 2012;71(1):15–21

Csontos, C., Rezman, B., Foldi, V., et al. Effect of N-acetylcysteine treatment on the expression of leukocyte surface markers after burn injury. Burns. 2011;37(3):453–464

Cuaz-Pérolin, C., Billiet, L., Baugé, E., et al. Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28(2):272–277

Dantzer, R. Depression and inflammation: an intricate relationship. Biol. Psychiatry. 2012;71(1):4–5

De Bacquer, D., Clays, E., Delanghe, J., and De Backer, G. Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation. Atherosclerosis. 2006;189(2):428–435

de Mejia, E. G., Ramirez-Mares, M. V., and Puangpraphant, S. Bioactive components of tea: cancer, inflammation and behavior. Brain Behav. Immun. 2009;23(6):721–731

de Oliveira Otto, M. C. C., Alonso, A., Lee, D.-H., et al. Dietary micronutrient intakes are associated with markers of inflammation but not with markers of subclinical atherosclerosis. Journal of Nutrition. 2011;141(8):1508–1515

Deshpande, R., Khalili, H., Pergolizzi, R. G., Michael, S. D., and Chang, M. D. Estradiol down-regulates LPS-induced cytokine production and NFkB activation in murine macrophages. Am. J. Reprod. Immunol. 1997;38(1):46–54

Devaraj S, Leonard S, Traber MG, et al. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med. 2008;44(6):1203-8.

Dinarello CA et al. A clinical perspective of IL-1β as the gatekeeper of inflammation. Eur J Immunol. 2011 May;41(5):1203-17. doi: 10.1002/eji.201141550.

Donnino MW et al. Coenzyme Q10 levels are low and may be associated with the inflammatory cascade in septic shock. Crit Care. 2011 Aug 9;15(4):R189.

Du, H., van der A, D. L., van Bakel, M. M. E., et al. Glycemic index and glycemic load in relation to food and nutrient intake and metabolic risk factors in a Dutch population. American Journal of Clinical Nutrition. 2008;87(3):655–661

Duntas, L. H. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm. Metab. Res. 2009;41(6):443–447

Emerging Risk Factors Collaboration, Kaptoge, S., Di Angelantonio, E., et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375(9709):132–140

Epstein, J., Docena, G., Macdonald, T. T., and Sanderson, I. R. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br J Nutr. 2010;103(6):824–832

Ernestam, S., Hafström, I., Werner, S., Carlström, K., and Tengstrand, B. Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function. The Journal of Rheumatology. 2007;34(7):1451–1458

Ernst, E. Frankincense: systematic review. BMJ. 2008;337:a2813

Ferrucci, L., Semba, R. D., Guralnik, J. M., et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010;115(18):3810–3816

Fitzhugh DJ et al. Bromelain treatment decreases neutrophil migration to sites of inflammation. Clin Immunol. 2008 Jul;128(1):66-74. Epub 2008 May 14.

Fleisher-Berkovich S et al. Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation. Peptides. 2009 Jul;30(7):1306-12. Epub 2009 Apr 10.

Flossmann E, Rothwell PM, British Doctors Aspirin Trial and the UK-TIA Aspirin Trial. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet. 2007;369(9573):1603-13.

Fried, S. K., Bunkin, D. A., and Greenberg, A. S. Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab. 1998;83(3):847–850

Galland, L. Diet and inflammation. Nutr Clin Pract. 2010;25(6):634–640

Gameiro, C., and Romao, F. Changes in the immune system during menopause and aging. Front Biosci (Elite Ed). 2010;2:1299–1303

Gayathri, B., Manjula, N., Vinaykumar, K. S., Lakshmi, B. S., and Balakrishnan, A. Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases. International Immunopharmacology. 2007;7(4):473–482

Ghanim, H., Sia, C. L., Korzeniewski, K., et al. A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab. 2011;96(5):1409–1414

Gilliver, S. C. Sex steroids as inflammatory regulators. J. Steroid Biochem. Mol. Biol. 2010;120(2-3):105–115

Gimeno, D., Kivimäki, M., Brunner, E. J., et al. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med. 2009;39(3):413–423

Giugliano, D., Ceriello, A., and Esposito, K. The Effects of Diet on Inflammation. J Am Coll Cardiol. 2006;48(4):677–685

Glorieux, G., Cohen, G., Jankowski, J., and Vanholder, R. Platelet/Leukocyte activation, inflammation, and uremia. Semin Dial. 2009;22(4):423–427

Goicoechea M et al. Effects of pentoxifylline on inflammatory parameters in chronic kidney disease patients: a randomized trial. J Nephrol. 2012 Jan 11:0. doi: 10.5301/jn.5000077. [Epub ahead of print]

Gómez-García, A., Martínez Torres, G., Ortega-Pierres, L. E., Rodríguez-Ayala, E., and Alvarez-Aguilar, C. [Rosuvastatin and metformin decrease inflammation and oxidative stress in patients with hypertension and dyslipidemia]. Rev Esp Cardiol. 2007;60(12):1242–1249

González O, Tobia C, Ebersole J, et al. Caloric restriction and chronic inflammatory diseases. Oral Dis. 2012;18(1):16-31.

Gordon, C. M., LeBoff, M. S., and Glowacki, J. Adrenal and gonadal steroids inhibit IL-6 secretion by human marrow cells. Cytokine. 2001;16(5):178–186

Green DR et al. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science. 2011 Aug 26;333(6046):1109-12.

Green, S., Dobrjansky, A., Carswell, E. A., et al. Partial purification of a serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA. 1976;73(2):381–385

Groesdonk HV et al. [Anti-inflammatory effects of pentoxifylline: importance in cardiac surgery]. Anaesthesist. 2009 Nov;58(11):1136-43. Review. German.

Gualano B et al. Reduced muscle carnosine content in type 2, but not in type 1 diabetic patients. Amino Acids. 2011 Nov 27. [Epub ahead of print]

Guillot, X., Semerano, L., Saidenberg-Kermanac'h, N., Falgarone, G., and Boissier, M.-C. Vitamin D and inflammation. Joint Bone Spine. 2010;77(6):552–557

Gupta SK et al. Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study. AIDS. 2010 Jun 1;24(9):1377-80.

Gupta, I., Parihar, A., Malhotra, P., et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur. J. Med. Res. 1997;2(1):37–43

Gupta, I., Parihar, A., Malhotra, P., et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med. 2001;67(5):391–395

Harikumar, K. B., Sung, B., Tharakan, S. T., et al. Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol. Cancer Res. 2010;8(5):751–761

He, K., Liu, K., Daviglus, M. L., et al. Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2009;103(9):1238–1243

Heffner, K. L. Neuroendocrine effects of stress on immunity in the elderly: implications for inflammatory disease. Immunol Allergy Clin North Am. 2011;31(1):95–108

Henry-Vitrac C, Ibarra A, Roller M, Merillon JM, Vitrac X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem. 2010 Apr 14;58(7):4141-4.

Hepgul G et al. Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways. Dig Dis Sci. 2010 Mar;55(3):617-25. Epub 2009 Mar 18.

Hipkiss AR. On the enigma of carnosine’s anti-ageing actions. Exp Gerontol. 2009 Apr;44(4):237-42.

Holtmeier, W., Zeuzem, S., Preiss, J., et al. Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: good safety profile but lack of efficacy. Inflamm. Bowel Dis. 2011;17(2):573–582

Hong, T., Tan, A. G., Mitchell, P., and Wang, J. J. A review and meta-analysis of the association between C-reactive protein and age-related macular degeneration. Surv Ophthalmol. 2011;56(3):184–194

Ikonomidis, I., Andreotti, F., Economou, E., Stefanadis, C., Toutouzas, P., and Nihoyannopoulos, P. Increased proinflammatory cytokines in patients with chronic stable angina and their reduction by aspirin. Circulation. 1999;100(8):793–798

Izadpanah F et al. Effect of intravenous pentoxifylline in inflammatory response in patients undergoing nephrolithotomy. J Endourol. 2009 Feb;23(2):323-8.

Jablonski, K. L., Chonchol, M., Pierce, G. L., Walker, A. E., and Seals, D. R. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011;57(1):63–69

Jha, R. K., Ma, Q., Sha, H., and Palikhe, M. Acute pancreatitis: a literature review. Med Sci Monit. 2009;15(7):RA147–56

Jha, R. K., Ma, Q., Sha, H., and Palikhe, M. Emerging role of resveratrol in the treatment of severe acute pancreatitis. Front Biosci (Schol Ed). 2010;2:168–175

Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN. gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci USA. 2000 Oct 10;97(21):11494-9.

Kadetoff, D., Lampa, J., Westman, M., Andersson, M., and Kosek, E. Evidence of central inflammation in fibromyalgia - Increased cerebrospinal fluid interleukin-8 levels. J. Neuroimmunol. 2011;

Kahmann, L., Uciechowski, P., Warmuth, S., et al. Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions. Rejuvenation Res. 2008;11(1):227–237

Kane, S. V., and Reddy, D. Hormonal replacement therapy after menopause is protective of disease activity in women with inflammatory bowel disease. Am J Gastroenterol. 2008;103(5):1193–1196

Karin, M., Lawrence, T., and Nizet, V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 2006;124(4):823–835

Kaser, A., and Tilg, H. “Metabolic aspects” in inflammatory bowel diseases. Curr Drug Deliv. 2011;

Kelishadi, R., Hashemipour, M., Adeli, K., et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8(6):505–510

Keller, E. T., Chang, C., and Ershler, W. B. Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J Biol Chem. 1996;271(42):26267–26275

Khanduja, K. L., Bhardwaj, A., and Kaushik, G. Resveratrol inhibits N-nitrosodiethylamine-induced ornithine decarboxylase and cyclooxygenase in mice. J. Nutr. Sci. Vitaminol. 2004;50(1):61–65

Khosla, S., Atkinson, E. J., Dunstan, C. R., and O'Fallon, W. M. Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine levels in normal elderly men. J Clin Endocrinol Metab. 2002;87(4):1550–1554

Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006 Jan-Feb;24(1):25-30.

Krishnan, A. V., Trump, D. L., Johnson, C. S., and Feldman, D. The role of vitamin D in cancer prevention and treatment. Endocrinol. Metab. Clin. North Am. 2010;39(2):401–18, table of contents

Kundu, J. K., and Surh, Y.-J. Inflammation: gearing the journey to cancer. Mutat Res. 2008;659(1-2):15–30

Lee, J., Taneja, V., and Vassallo, R. Cigarette Smoking and Inflammation: Cellular and Molecular Mechanisms. J. Dent. Res. 2011;

Levitan, E. B., Cook, N. R., Stampfer, M. J., et al. Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. Metabolism. 2008;57(3):437–443

Li W et al. Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease. Lipids Health Dis. 2011 Apr 8;10:49. Review.

Liu, L. C. Y., Voors, A. A., van Veldhuisen, D. J., et al. Vitamin D status and outcomes in heart failure patients. Eur. J. Heart Fail. 2011;13(6):619–625

Lopes de Jesus CC et al. lline for diabetic retinopathy. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006693. Review.

Lopez-Garcia, E., Schulze, M. B., Manson, J. E., et al. Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women. J Nutr. 2004;134(7):1806–1811

Lopez-Garcia, E., Schulze, M. B., Meigs, J. B., et al. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr. 2005;135(3):562–566

Luo, P., and Wang, M.-H. Eicosanoids, β-cell function, and diabetes. Prostaglandins Other Lipid Mediat. 2011;95(1-4):1–10

Lv D et al. Pentoxifylline versus medical therapies for subfertile women with endometriosis. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007677. Review.

Ma, Y., Hébert, J., Li, W., and Bertone-Johnson, E. Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study. Nutrition. 2008;

Maehira, F., Luyo, G. A., Miyagi, I., et al. Alterations of serum selenium concentrations in the acutephase of pathological conditions. Clin. Chim. Acta. 2002;316(1-2):137–146

Maggio, M., Basaria, S., Ble, A., et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J Clin Endocrinol Metab. 2006;91(1):345–347

Maiti R et al. Effect of Pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients. Vascul Pharmacol. 2007 Aug-Sep;47(2-3):118-24. Epub 2007 Jun 2.

Mariani, E., Cattini, L., Neri, S., et al. Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status. Biogerontology. 2006;7(5-6):449–459

Marik, P. E., and Varon, J. Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review. Clin Cardiol. 2009;32(7):365–372

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., and Tschopp, J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237–241

Medzhitov, R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428–435

Melgarejo, E., Medina, M. A., Sánchez-Jiménez, F., and Urdiales, J. L. Targeting of histamine producing cells by EGCG: a green dart against inflammation? J. Physiol. Biochem. 2010;66(3):265–270

Meydani M. Vitamin E and atherosclerosis: beyond prevention of LDL oxidation. J Nutr. 2001Feb;131(2):366S-8S.

Meyer, O. Anti-CRP antibodies in systemic lupus erythematosus. Joint Bone Spine. 2010;77(5):384–389

Miyawaki, T., Aono, H., Toyoda-Ono, Y., Maeda, H., Kiso, Y., and Moriyama, K. Antihypertensive effects of sesamin in humans. J. Nutr. Sci. Vitaminol. 2009;55(1):87–91

Mohamed-Ali, V., Goodrick, S., Rawesh, A., et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997;82(12):4196–4200

Molavi, B., Rassouli, N., Bagwe, S., and Rasouli, N. A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications. Vasc Health Risk Manag. 2007;3(6):967–973

Moschen, A. R., Molnar, C., Geiger, S., et al. Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression. Gut. 2010;59(9):1259–1264

Mosquera JA. [Role of the receptor for advanced glycation end products (RAGE) in inflammation]. Invest Clin. 2010 Jun;51(2):257-68.

Mozaffarian, D., and Pischon, T. Dietary intake of trans fatty acids and systemic inflammation in women. American Journal of …. 2004;

Murphy SL. et al. Deaths: Preliminary Data for 2010. National Vital Statistics Report 60:4; 1/11/2012.

Myhrstad, M. C. W., Narverud, I., Telle-Hansen, V. H., et al. Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women. Br J Nutr. 2011;106(12):1826–1835

Nagendran MV. Effect of green coffee bean extract (GCE), High in Chlorogenic Acids, on Glucose Metabolism. Poster presentation number: 45-LB-P. Obesity 2011, the 29th Annual Scientific Meeting of the Obesity Society. Orlando, Florida. October 1-5, 2011.

Nappo, F., Esposito, K., Cioffi, M., et al. Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals. J Am Coll Cardiol. 2002;39(7):1145–1150

Nascimento, M. M., Suliman, M. E., Silva, M., et al. Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study. Perit Dial Int. 2010;30(3):336–342

Nguyen Khoa, T., Massy, Z. A., Witko-Sarsat, V., et al. Oxidized low-density lipoprotein induces macrophage respiratory burst via its protein moiety: A novel pathway in atherogenesis? Biochem Biophys Res Commun. 1999;263(3):804–809

Nielsen, B. M., Nielsen, M. M., Jakobsen, M. U., et al. A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI. Br J Nutr. 2011;106(8):1245–1252

North, C. J., Venter, C. S., and Jerling, J. C. The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Eur J Clin Nutr. 2009;63(8):921–933

Onken JE et al. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21.

Ortega Martinez de Victoria, E., Xu, X., Koska, J., et al. Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians. Diabetes. 2009;58(2):385–393

Pan, Z., Agarwal, A. K., Xu, T., et al. Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC Med Genomics. 2008;1:7

Patrono C, Rocca B. Aspirin: promise and resistance in the new millennium. Arterioscler Thromb Vasc Biol. 2008;28(3):s25-32.

Payette, C., Blackburn, P., Lamarche, B., et al. Sex differences in postprandial plasma tumor necrosis factor-alpha, interleukin-6, and C-reactive protein concentrations. Metab. Clin. Exp. 2009;58(11):1593–1601

Peairs, A. D., Rankin, J. W., and Lee, Y. W. Effects of acute ingestion of different fats on oxidative stress and inflammation in overweight and obese adults. Nutr J. 2011;10:122

Pervanidou, P., and Chrousos, G. P. Metabolic consequences of stress during childhood and adolescence. Metab. Clin. Exp. 2011;

Pfister F et al. Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cell Physiol Biochem. 2011;28(1):125-36. Epub 2011 Aug 16.

Pickup, J. C., Chusney, G. D., Thomas, S. M., and Burt, D. Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci. 2000;67(3):291–300

Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., Willett, W. C., and Rimm, E. B. Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation. 2003;108(2):155–160

Pontet, J., Contreras, P., Curbelo, A., et al. Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients. J Crit Care. 2003;18(3):156–163

Poppitt, S. D., Keogh, G. F., Lithander, F. E., et al. Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition. 2008;24(4):322–329

Pradeep, A. R., Kathariya, R., Arjun Raju, P., Sushma Rani, R., Sharma, A., and Raghavendra, N. M. Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case-control study. Int Urol Nephrol. 2011;

Prasad, A. S. Zinc: role in immunity, oxidative stress and chronic inflammation. Current Opinion in Clinical Nutrition and Metabolic Care. 2009;12(6):646–652

Pruski, M., Krysiak, R., and Okopien, B. Pleiotropic action of short-term metformin and fenofibrate treatment, combined with lifestyle intervention, in type 2 diabetic patients with mixed dyslipidemia. Diabetes Care. 2009;32(8):1421–1424

Radomska-Leśniewska, D. M., Sadowska, A. M., Van Overveld, F. J., Demkow, U., Zieliński, J., and De Backer, W. A. Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells. J. Physiol. Pharmacol. 2006;57 Suppl 4:325–334

Ray, P., Ghosh, S. K., Zhang, D. H., and Ray, A. Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS letters. 1997;409(1):79–85

Reid, D., Toole, B. J., Knox, S., et al. The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. American Journal of Clinical Nutrition. 2011;93(5):1006–1011

Ridker, P. M., Danielson, E., Fonseca, F. A. H., et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195–2207

Rodriguez de Sotillo DV, Hadley M, Sotillo JE. Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA. J Nutr Biochem. 2006 Jan;17(1):63-71.

Rolland, Y., Abellan van Kan, G., Gillette-Guyonnet, S., and Vellas, B. Cachexia versus sarcopenia. Current Opinion in Clinical Nutrition and Metabolic Care. 2011;14(1):15–21

Rothwell PM, Fowkes FG, Belch JF, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011;377(9759):31-41.

Rothwell PM, Wilson M, Elwin CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010;376(9754):1741-50.

Rucker R et al. Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev. 2009 Sep;14(3):268-77.

Salinas CA, Kwon EM, FitzGerald LM, et al. Use of aspirin and other nonsteroidal antiinflammatory medications in relation to prostate cancer risk. Am J Epidemiol. 2010;172(5):578-90.

Sanchez-Ramirez GM et al. Benfotiamine relieves inflammatory and neuropathic pain in rats. Eur J Pharmacol. 2006 Jan 13;530(1-2):48-53. Epub 2005 Dec 15.

Schmelzer C et al. Functions of coenzyme Q10 in inflammation and gene expression. Biofactors. 2008;32(1-4):179-83.

Schrager, M. A., Metter, E. J., Simonsick, E., et al. Sarcopenic obesity and inflammation in the InCHIANTI study. J Appl Physiol. 2007;102(3):919–925

Secor ER et al. Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol. 2005 Sep;237(1):68-75. Epub 2005 Dec 6.

Secor ER et al. Oral Bromelain Attenuates Inflammation in an Ovalbumin-induced Murine Model of Asthma. Evid Based Complement Alternat Med. 2008 Mar;5(1):61-9.

Sengupta, K., Alluri, K. V., Satish, A. R., et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res. Ther. 2008;10(4):R85

Sengupta, K., Krishnaraju, A. V., Vishal, A. A., et al. Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366–377

Serhan, C. N., and Oliw, E. Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest. 2001;107(12):1481–1489

Serhan, C. N., Hong, S., Gronert, K., et al. Resolvins: A Family of Bioactive Products of Omega-3 Fatty Acid Transformation Circuits Initiated by Aspirin Treatment that Counter Proinflammation Signals. Journal of Experimental Medicine. 2002;196(8):1025–1037

Sethi, G., Sung, B., and Aggarwal, B. B. TNF: a master switch for inflammation to cancer. Front Biosci. 2008;13:5094–5107

Shimizu, S., Akimoto, K., Shinmen, Y., Kawashima, H., Sugano, M., and Yamada, H. Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis. Lipids. 1991;26(7):512–516

Shoeb M et al. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med. 2012 Jan 1;52(1):182-90. Epub 2011 Oct 24.

Singh, R., Akhtar, N., and Haqqi, T. M. Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. Life Sci. 2010;86(25-26):907–918

Singh, S., Khajuria, A., Taneja, S. C., Johri, R. K., Singh, J., and Qazi, G. N. Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. Phytomedicine. 2008;15(6-7):400–407

Singh, T., and Newman, A. B. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011;10(3):319–329

Sjoholm A, Berggren PO, Cooney RV. gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide. Biochem Biophys Res Commun. 2000 Oct 22;277(2):334-40.

Slade, G. D., Ghezzi, E. M., Heiss, G., Beck, J. D., Riche, E., and Offenbacher, S. Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med. 2003;163(10):1172–1179

Sobel, B. E., Hardison, R. M., Genuth, S., et al. Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Circulation. 2011;124(6):695–703

Sobolewski, C., Cerella, C., Dicato, M., Ghibelli, L., and Diederich, M. The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol. 2010;2010:215158

Sohet FM et al. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol. 2009 Dec 1;78(11):1391-400. Epub 2009 Jul 23.

Solheim, S., Arnesen, H., Eikvar, L., Hurlen, M., and Seljeflot, I. Influence of aspirin on inflammatory markers in patients after acute myocardial infarction. Am J Cardiol. 2003;92(7):843–845

Solheim, S., Pettersen, A. A., Arnesen, H., and Seljeflot, I. No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease. Thromb. Haemost. 2006;96(5):660–664

Sourris KC et al. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med. 2012 Feb 1;52(3):716-23. Epub 2011 Nov 21.

Stancu, C., and Sima, A. Statins: mechanism of action and effects. J. Cell. Mol. Med. 2001;5(4):378–387

Steptoe, A., Gibson, E. L., Vuononvirta, R., et al. The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial. Atherosclerosis. 2007;193(2):277–282

Stracke H et al. A benfotiamine-vitamin B combination in treatment of diabetic polyneuropathy. Exp Clin Endocrinol Diabetes. 1996;104(4):311-6.

Stracke H et al. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008 Nov;116(10):600-5. Epub 2008 May 13.

Tao r et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007 Nov 16;363(2):257-62. Epub 2007 Aug 14.

Taylor, L., Loerbroks, A., Herr, R. M., Lane, R. D., Fischer, J. E., and Thayer, J. F. Depression and smoking: mediating role of vagal tone and inflammation. Ann Behav Med. 2011;42(3):334–340

Toma L, Stancu CS, Botez GM, Sima AV, Simionescu M. Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose. Biochem Biophys Res Commun. 2009 Dec 18;390(3):877-82.

Trakada, G., Chrousos, G., Pejovic, S., and Vgontzas, A. Sleep Apnea and its association with the Stress System, Inflammation, Insulin Resistance and Visceral Obesity. Sleep Med Clin. 2007;2(2):251–261

Trayhurn, P., and Wood, I. S. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem. Soc. Trans. 2005;33(Pt 5):1078–1081

Tsai SJ Antioxidative and Anti-Inflammatory Protection from Carnosine in the Striatum of MPTP-Treated Mice. J Agric Food Chem. 2010 Oct 6. [Epub ahead of print]

Tschopp J. Mitochondria: Sovereign of inflammation? Eur J Immunol. 2011 May;41(5):1196-202. doi: 10.1002/eji.201141436.

Uribarri J, Cai W, Sandu O, Peppa M, Goldberg T, Vlassara H. Diet-derived advanced glycation end products are major contributors to the body’s AGE pool and induce inflammation in healthy subjects. Ann N Y Acad Sci. 2005 Jun;1043:461-6.

Vaishnava, P., Narayan, R., and Fuster, V. Understanding systemic inflammation, oral hygiene, and cardiovascular disease. Am. J. Med. 2011;124(11):997–999

van Westerloo, D. J. The vagal immune reflex: a blessing from above. Wien Med Wochenschr. 2010;160(5-6):112–117

Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab. 2000;85(3):1151–1158

Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., and Chrousos, G. P. Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab. 1997;82(5):1313–1316

Vgontzas, A. N., Zoumakis, M., Bixler, E. O., et al. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab. 2003;88(5):2087–2095

Vistoli G et al. Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs. Amino Acids. 2012 Jan 28. [Epub ahead of print]

Vlassara, H., Cai, W., Crandall, J., et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci USA. 2002;99(24):15596–15601

Vural, P., Akgul, C., and Canbaz, M. Effects of hormone replacement therapy on plasma pro-inflammatory and anti-inflammatory cytokines and some bone turnover markers in postmenopausal women. Pharmacol. Res. 2006;54(4):298–302

Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002 Dec;9(8):681-6.

Walston, J., Xue, Q., Semba, R. D., et al. Serum antioxidants, inflammation, and total mortality in older women. Am. J. Epidemiol. 2006;163(1):18–26

Weber, C., Erl, W., Pietsch, A., and Weber, P. C. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation. 1995;91(7):1914–1917

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., and Ferrante, A. W. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–1808

Weiss, E. P., Villareal, D. T., Fontana, L., Han, D.-H., and Holloszy, J. O. Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging. 2011;3(5):533–542

White, B., and Judkins, D. Z. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011;60(3):155–156

Windgassen, E. B., Funtowicz, L., Lunsford, T. N., Harris, L. A., and Mulvagh, S. L. C-reactive protein and high-sensitivity C-reactive protein: an update for clinicians. Postgrad Med. 2011;123(1):114–119

Witko-Sarsat, V., Friedlander, M., Nguyen Khoa, T., et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol. 1998;161(5):2524–2532

Wong, C. P., and Ho, E. Zinc and its role in age-related inflammation and immune dysfunction. Mol. Nutr. Food Res. 2011;

Wu, J. H. Y., Hodgson, J. M., Clarke, M. W., et al. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies. Hypertension. 2009;54(5):1151–1158

Xiong XH et al. Production and radioprotective effects of pyrroloquinoline quinone. Int J Mol Sci. 2011;12(12):8913-23. Epub 2011 Dec 5.

Yaffe, K., Lindquist, K., Penninx, B. W., et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61(1):76–80

Yuan, G., Wahlqvist, M. L., He, G., Yang, M., and Li, D. Natural products and anti-inflammatory activity. Asia Pac J Clin Nutr. 2006;15(2):143–152

Zampelas, A., Panagiotakos, D. B., Pitsavos, C., et al. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. J Am Coll Cardiol. 2005;46(1):120–124.