Health Concerns

Life Extension Suggestions

  • Folate/folic acid, with several options:
    • 5-MTHF/L-methylfolate (active folate): 800 – 1000 mcg daily; certain individuals may require up to 5 mg daily (under medical supervision). This is the best choice for those with higher homocysteine levels, those with the MTHFR 677TT genotype, and those who are not getting their homocysteine levels low enough with regular folic acid.
    • Natural folate: 800 – 1600 mcg. This is the form that is found naturally in food.
    • Folic acid: 1 – 2 mg. This is another option. However, if a 2 mg dose does not provide benefit then consider using the active folate (5-MTHF) form instead.
  • N-acetylcysteine (NAC): 600 – 1800 mg daily
  • SAMe (S-adenosylmethionine): 400 mg two to four times daily
  • Taurine: 1000 – 3000 mg daily
  • TMG (trimethylglycine): 2000 – 6000 mg daily
  • Vitamin B12 (cobalamin): 1 – 2 mg daily
  • Vitamin B2 (riboflavin): 10 – 100 mg daily
  • Vitamin B6 (as pyridoxal-5’-phosphate): 100 – 200 mg daily
  • Zinc (as OptiZinc®): 30 – 60 mg daily
  • Micronized creatine: 500 mg (in capsule form) four to eight times daily
  • CDP Choline: 250 – 500 mg daily.

In addition, the following blood testing resources may be helpful:

Disclaimer and Safety Information

This information (and any accompanying material) is not intended to replace the attention or advice of a physician or other qualified health care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease or condition should first consult with and seek clearance from a physician or other qualified health care professional. Pregnant women in particular should seek the advice of a physician before using any protocol listed on this website. The protocols described on this website are for adults only, unless otherwise specified. Product labels may contain important safety information and the most recent product information provided by the product manufacturers should be carefully reviewed prior to use to verify the dose, administration, and contraindications. National, state, and local laws may vary regarding the use and application of many of the treatments discussed. The reader assumes the risk of any injuries. The authors and publishers, their affiliates and assigns are not liable for any injury and/or damage to persons arising from this protocol and expressly disclaim responsibility for any adverse effects resulting from the use of the information container herein.

The protocols raise many issues that are subject to change as new data emerge. None of our suggested protocol regimens can guarantee health benefits. The publisher has not performed independent verification of the data contained herein, and expressly disclaim responsibility for any error in literature.