Fibromyalgia

Fibromyalgia is a relatively common disorder characterized by widespread muscle pain, stiffness, and disturbed sleep. People with fibromyalgia may have pain that lasts for months, or even years. Some people with fibromyalgia will be in continual pain. The disease, however, is complex and poorly understood. In 1990, the American College of Rheumatology set up criteria for the classification of fibromyalgia. Researchers have not yet uncovered the cause of fibromyalgia, although they have presented a number of theories (Kasper DL et al 2005).

Fibromyalgia tends to occur in women much more often than in men. It is estimated that more than 80 percent of people with fibromyalgia are women between the ages of 30 and 60 years (Ataoglu S et al 2003). As many as 10 million people in the United States battle this chronic illness, and fully 5 percent of the world’s population may contend with it (Goldenberg D 2002).

Patients with fibromyalgia often present with comorbid conditions such as:

• Chronic fatigue
• Sleep disorders
• Numbness and tingling in various parts of the body
• Some degree of sexual disfunction

Studies in Australia and Canada have shown that 50 percent of patients with fibromyalgia who took no medication experienced a complete remission of all symptoms within 2 years. The other 50 percent had one or more symptoms of fibromyalgia for more than 2 years (Goldenberg D 2002).

The Causes of Fibromyalgia

Although we do not yet know what causes fibromyalgia, great strides have been made in recent years in uncovering the underlying pathology of the disease. In fact, in recent years, researchers have begun to rethink fibromyalgia. For many years, fibromyalgia was thought to be a muscle disorder, but new research is also implicating the central nervous system. According to the newest research, it is a disease characterized by central sensitization of the spinal cord and central nervous system (Bennett R 2005; Gerwin RD 2005). This sensitization may occur because of inflammatory cytokines that trigger inducible nitric oxide synthase (INOS) in muscle tissue. The INOS causes inappropriate stimulation of pain receptors and an increase in oxidants such as the peroxynitrite radical and other reactive oxygen species.

Numerous studies have examined the role of nitric oxide in fibromyalgia, with interesting results:

• A study found that women with fibromyalgia experienced a reduced flow of nutrients to muscles after exercise. Researchers speculated that this might be related to elevated levels of INOS, which stimulates increased levels of nitric oxide (McIver KL et al 2006).
• A paper examining the recent theories on the cause of fibromyalgia hypothesized that oxidative stress may play an important part in the disease. The paper called for double-blind studies to be done on antioxidants in the treatment of the disease (Ozgocmen S et al 2005a).
• A review of dozens of separate studies found that the central sensitization associated with fibromyalgia may be caused by stimulation of pain receptors in the muscles that causes changes in the spinal cord and central nervous system. These changes are strongly dependent on nitric oxide (Mense S 1999).
• A hypothesis presented in one journal proposed that abnormally elevated levels of nitric oxide within the central nervous system generate high levels of peroxynitrite, an oxidant product of nitric oxide. This causes oxidative damage in tissues affected by the disorder (Pall ML 2005c).

While there is still much to learn, these new findings suggest several targets for fibromyalgia therapy, including antioxidants to limit oxidative damage and nutrients that inhibit pain receptors and transmitters in the muscles. One important pain transmitter is substance P, which is elevated in the cerebrospinal fluid of people with fibromyalgia (Stratz T et al 2004).

Of course, this is not the only avenue of research. Fibromyalgia is a complex disease that is influenced by multiple factors, including hormonal and psychological issues. For instance, the increased prevalence of fibromyalgia in women suggests a hormonal influence. This association is strengthened by observations that women who have fibromyalgia are much more likely to have late onset of menstruation and lower fertility rates than women without fibromyalgia (Schochat T et al 2003). Many of the most common fibromyalgia symptoms—widespread muscle pain, fatigue, poor sleep, gastrointestinal problems, and depression—also occur regularly in people who have demonstrated hormonal deficiencies (Adler GK et al 2002).

Alternatively, many patients with fibromyalgia report that their symptoms began after they had experienced trauma—particularly injuries to the head and neck. Fibromyalgia also seems to be aggravated by infection; it is known that chronic viral infection can trigger symptoms (Adak B et al 2005; Goldenberg D 2002).

Symptoms and Diagnosis of Fibromyalgia

All people with fibromyalgia have widespread, significant pain. Other symptoms include, in descending order from most common to least common (Wallace D et al 2002):

• Unrefreshing sleep
• Stiffness
• Tension headache
• Painful menstrual periods
• Irritable bowel, with recurring diarrhea and constipation
• Vaginal pain and dryness
• Difficulty with concentration and related cognitive functions
• Depression and mood disorders
• Restless leg syndrome
• Irritable bladder and urinary complaints

Fibromyalgia has also been associated with depression of the hypothalamic-pituitary-adrenal (HPA) axis. Researchers believe this may be caused by the chronic pain and sleeplessness associated with the disease, which tends to depress HPA activity—including growth hormone, androgens, and cortisol levels (Calis M et al 2004; Geenen R et al 2002; Okifuji A et al 2002). Dehydroepiandrosterone (DHEA) levels are also diminished in women who have fibromyalgia (Dessein PH et al 1999).

Diagnosis of fibromyalgia is complicated by the fact that there is no single test that detects it. Instead, it is diagnosed by a history of widespread pain and tenderness in at least 11 of the 18 pressure points identified by the American College of Rheumatology. These pressure points are located in the neck, shoulders, back, arms, and legs. Before a diagnosis of fibromyalgia is confirmed, physicians usually need to exclude a wide variety of other conditions, including cancer, leukemia, hypothyroidism, anemia, and multiple sclerosis.

Conventional Treatment

There are no medications available that successfully treat all symptoms of fibromyalgia. Instead, conventional treatment involves treating individual symptoms, most often analgesics to kill pain, antidepressants to elevate mood and alleviate pain (often working synergistically with the analgesics), and sleep agents to promote restful sleep. In many cases, just getting a diagnosis of fibromyalgia is helpful to the patient to confirm that the disease is not all in his or her head. Unfortunately, the drugs prescribed to treat symptoms of fibromyalgia all have adverse effects, especially because the condition often requires long-term treatment. Drugs used to treat symptoms of fibromyalgia include:

Nonsteroidal anti-inflammatory drugs (NSAIDs). Many physicians begin treatment of fibromyalgia with NSAIDs such as ibuprofen or naproxen, which successfully dampen muscular pain (but seldom eliminate it). Other physicians report success in prescribing NSAIDs in the category of COX-2 inhibitors such as celecoxib (Celebrex®), which was developed to have fewer adverse effects than ibuprofen and naproxen. All NSAIDs, including COX-2 inhibitors, work by blocking enzymes that produce chemicals involved in inflammation, such as prostaglandins and leukotrienes. Recently, COX-2 inhibitors have been linked to increased risk of heart attack, leading to the removal of rofecoxib (Vioxx®) and valdecoxib (Bextra®) from the market. NSAIDs are generally safe when used for limited periods, but they can have significant negative side effects if used chronically. Although this makes them poor choices for long-term treatment of fibromyalgia, patients may want to consider using NSAIDs for short-term flare-ups of pain.

Antidepressants. Antidepressants are commonly recommended. Medications that specifically act by sustaining levels of the brain chemical serotonin, which plays a key role in mitigating depression and anxiety, have proven successful in raising energy levels—particularly sertraline (Zoloft®), fluoxetine (Prozac®), paroxetine (Paxil®), and citalopram (Celexa®). So-called tricyclic antidepressants, which include amitriptyline (Elavil®) and cyclobenzaprine (Flexeril®), are successful in treating pain, in addition to treating low energy and insomnia, although many people have adverse effects such as constipation, dry mouth, increased appetite, and lowered libido.

Sleep aids. Medications such as zolpidem (Ambien®) that are designed to promote sleep can be successful, but people usually develop a tolerance to sleep medications when used over time; the drugs just stop working. One way of delaying or avoiding the tolerance effect is to use a different sleep aid each night. For example, a patient with fibromyalgia may want to start off with the following drug combinations:

• Night 1: 5 to 10 milligrams (mg) of zolpidem
• Night 2: 1 to 3 mg of clonazepam (Klonopin®)
• Night 3: 23 to 46 mg of clorazepate (Tranxene®)
• Night 4: 5 to 10 mg of zolpidem again, followed by clonazepam the next night and clorazepate the next.

Additional sleep aids include the tricyclic antidepressant amitriptyline (which has many side effects), the over-the-counter drug doxylamine hydrochloride (sold under the brand-name Unisom® and generically), and melatonin in doses of 300 micrograms (mcg) to 6 mg at bedtime.

Limiting Damage with Antioxidants

Today’s most exciting research implicates oxidative damage as an underlying problem in fibromyalgia and calls for more research into the use of antioxidants and omega-3 fatty acids to fight inflammation and scavenge free radicals. Many studies have found oxidative damage in people with fibromyalgia (Bagis S et al 2005; Hanninen O et al 2000; Ozgocmen S et al 2005a, 2005b). In addition, levels of superoxide dismutase, an internal antioxidant, are reduced in women with fibromyalgia (Bagis S et al 2005).

Patients with chronic fatigue syndrome—whose symptoms often are the same as those of patients with fibromyalgia—have been shown to have both high levels of oxidants in their systems and low levels of the antioxidant vitamin E (Vecchiet J et al 2003). A study of patients with fibromyalgia and a number of other chronic pain conditions demonstrated a decrease in joint stiffness and pain when subjects shifted to a living-foods (foods that have not been cooked or heated) diet, which is rich in antioxidants, lactobacilli, and fiber (Hanninen O et al 2000).

A Washington State University researcher hypothesized that vigorous antioxidant supplementation may help minimize damage from peroxynitrite and other oxidants (Pall ML 2005a). Research conducted by the Agricultural Research Service of the US Department of Agriculture (USDA) determined that blueberries (which can be consumed fresh, frozen, canned, or as an extract) are highest overall in total antioxidant capacity (Wu X et al 2004). Other antioxidants that patients with fibromyalgia should take include selenium, vitamin C, and vitamin E.

Hormonal Therapy for Fibromyalgia

Because of the hormonal connection, people who have fibromyalgia should consider getting a full hormonal blood test panel. If any hormones are out of balance, hormonal modulation therapy should be implemented. Studies indicate that patients with fibromyalgia may benefit from hormonal modulation therapy (Geenen R et al 2002). In addition, a subset of patients who are severely deficient in growth hormone may benefit from growth hormone replacement (Bennett RM 2002).

Support for hormonal replacement in fibromyalgia is mostly anecdotal. Integrative physicians have observed that patients with fibromyalgia often have symptoms—such as widespread pain, migraine, poor sleep, and gastrointestinal complaints—that are similar to people who have hormonal deficiencies. Also, hormonal testing often reveals that women who have fibromyalgia have low levels of crucial hormones. It is important when considering bioidentical hormonal replacement therapy to seek the advice of a qualified physician and to have your blood tested.

Boosting Adenosine Triphosphate Levels

One study demonstrated that patients with fibromyalgia tend to have low levels of adenosine triphosphate (ATP), the molecule that is essential for storing and transporting energy within the cells of all living organisms (Park JH et al 1998). One case report suggests that supplementation with D-ribose, the 5-carbon sugar that forms the base of ATP, may be helpful (Gebhart B et al 2004). Additional nutritional supplements appear to support the production of ATP, including the following:

Magnesium and malic acid. Magnesium is essential to healthy muscle function. The enzymes that liberate energy from ATP require magnesium to function properly. A review of studies on magnesium and malic acid found that blood levels of these two nutrients vary considerably in people with fibromyalgia, but multiple, controlled studies have found magnesium and malic acid to be effective in relieving the symptoms of fibromyalgia (Holdcraft LC et al 2003).

Vitamin B6. Pyridoxine is required to boost the action of magnesium and malic acid in the creation of ATP. Vitamin B6 supplementation may be considered for patients with fibromyalgia whose vitamin B6 levels are abnormally low.