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Fibromyalgia
Getting a Good Night’s Sleep
Melatonin is a pineal hormone that has been widely studied for its ability to produce sleep. In the body, melatonin is secreted in response to darkness, causing sleepiness.
Because so many patients with fibromyalgia have insomnia or unrefreshing sleep, researchers have sought to determine whether melatonin can be of specific help to them as a sleep agent. Studies have found that people with fibromyalgia have low melatonin levels. Supplementation with melatonin resulted in improved sleep and lowered requirements for prescription drugs (Rohr UD et al 2002). A Swedish study determined that patients with fibromyalgia produce less melatonin during hours of darkness than do healthy control subjects, making melatonin therapy potentially helpful as a sleep aid (Wikner J et al 1998). Researchers in Argentina conducted a pilot study in which they found that sleep patterns, sleep quality, and pain measures markedly improve in patients with fibromyalgia after 4 weeks of treatment with melatonin (Citera G et al 2000). In the United States, a double-blind, placebo-controlled study showed that 20 percent of the patients with fibromyalgia significantly improved their sleep patterns and quality when they took 6 mg of melatonin each night before bed.
Diet and Lifestyle Approaches
Patients with fibromyalgia can do a number of things to help diminish their pain, deepen their sleep, and generally improve their quality of life.
Diet. No controlled studies have been undertaken to date to test whether specific foods can alleviate symptoms of fibromyalgia. The following dietary guidelines may help patients with fibromyalgia (Hanninen O et al 2000):
- Consume plenty of calcium to support bone density. Foods high in calcium include milk, ice cream, yogurt, broccoli, hard cheeses, oysters, sardines, spinach, and oranges.
- Apples are high in malic acid, an antioxidant important in limiting muscle pain.
- Blueberries have been shown by the USDA to be higher in antioxidants than any other fruit, vegetable, nut, or herb.
- Carbohydrates increase serotonin levels, essential fatty acids reduce fatigue, and protein helps improve mental alertness (Wallace D et al 2002).
- Caffeine, a strong stimulant, should be avoided, particularly late in the day, to ensure that it does not negatively affect sleep.
- Alcohol should never be used to alleviate or mask pain.
Exercise. Moderate, regular exercise has been shown to reduce symptoms. Patients with fibromyalgia should work some of the following exercises into their schedule:
- Walk 20 to 40 minutes daily. Walking—outdoors when possible—is perhaps the best regular exercise.
- Swim 30 to 60 minutes three times a week. Swimming can successfully strengthen and tone painful muscles.
- Do isometric and stretching exercises. These types of exercises, particularly those focused on muscle groups susceptible to fibromyalgia pain, are vitally important.
- Strengthen and stretch muscles through yoga. Yoga is also an excellent way to engage with other people and take your mind off pain.
- Maintain good posture at all times. Don’t stay in a single position for long periods.
- Use supports such as armrests, railings, pillows, and slings to help avoid needlessly stressing sensitive muscles.
- Focus as much as possible on relaxation and stress reduction. Deep breathing, meditation, and other forms of conscious relaxation are often quite helpful.
Tobacco use. People with fibromyalgia should not smoke or use tobacco. Smokers with fibromyalgia have lower pain thresholds and more sleep problems than nonsmokers. Nicotine withdrawal can cause muscle spasms, and vascular constriction is worsened by smoking, leading to increased numbness, burning, and tingling (Wallace D et al 2002).
Other Treatments. Many patients with fibromyalgia report excellent results fighting pain with the help of therapists trained to use a variety of the following musculoskeletal and psychological treatments:
- Regular massage. Offers significant pain relief.
- Chiropractic. Chiropractors work to align the spine for optimal nerve flow and to increase range of motion and relax muscles.
- Physical and occupational therapy. Physical and occupational therapists, particularly those specifically trained to work with patients who have fibromyalgia, can design rehabilitation programs involving both manipulation and exercise that often show positive results.
- Acupuncture. A 2500-year-old treatment system, using very thin needles, that has shown moderate degrees of effectiveness in treating both pain and fatigue in patients with fibromyalgia.
- Psychotherapy, counseling, and support groups. These groups can be enormously beneficial to people with fibromyalgia, offering great assistance with issues such as anxiety, loss of self-esteem, anger, shame, depression, and relationship challenges.
Life Extension Foundation Recommendations
The Life Extension Foundation’s approach to fibromyalgia takes into account the many facets of the disease. The following supplements have been shown to reduce oxidative stress and inflammation, support healthy ATP levels in cells, aid in restful sleep and digestion, and support muscle function:
- Life Extension Mix—Follow label directions. Life Extension Mix provides a balanced mix of antioxidants and other nutrients.
- Magnesium—160 to 500 milligrams (mg) daily
- Malic acid—600 mg daily
- Vitamin B6—250 mg daily. High doses of vitamin B6 can cause neuropathy (nerve damage).
- Vitamin C—1000 to 2000 mg daily
- Selenium—200 micrograms (mcg) daily
- SODzyme—2000 mg daily. This special supplement enhances the levels of superoxide dismutase, an internal antioxidant.
- D-Ribose—3 grams (g) daily
- Gamma E—at least 200 mg daily
- Omega-3 fatty acids—1400 mg of eicosapentaenoic acid (EPA) and 1000 mg of docosahexaenoic acid (DHA)
- Blueberry extract—500 mg daily
- Melatonin—300 mcg to 6 mg daily
- DHEA—Starting dose of 15 to 75 mg daily. Have blood tested in 3 to 6 weeks to make sure optimal levels are maintained.
In addition to these supplements, hormonal testing is recommended. If levels are low, bioidentical hormonal replacement may be recommended. For more information about hormonal testing, call the Life Extension Foundation at 1-800-544-4440. Patients who are deficient in growth hormone should consult with a qualified physician.
Finally, patients who have been conventionally treated may have gastrointestinal problems from the many drugs that are often prescribed. These drugs may alter the levels of beneficial bacteria in the gut. For this reason, a person who has fibromyalgia should take probiotics, including the lactobacillus group of beneficial bacteria, to restore gastrointestinal function. |
Fibromyalgia Safety Caveats
An aggressive program of dietary supplementation should not be launched without the supervision of a qualified physician. Several of the nutrients suggested in this protocol may have adverse effects. These include:
DHEA
- Do not take DHEA if you could be pregnant, are breastfeeding, or could have prostate, breast, uterine, or ovarian cancer.
- DHEA can cause androgenic effects in woman such as acne, deepening of the voice, facial hair growth and hair loss.
D-Ribose
- Do not take D-ribose if you have gout.
- Do not take D-ribose if you have elevated uric acid levels. D-ribose can elevate uric acid levels.
- Consult your doctor before taking D-ribose if you have diabetes or hypoglycemia. D-ribose can cause or exacerbate hypoglycemia. See your doctor and monitor your blood glucose level frequently if you take D-ribose and have hyperglycemia or diabetes.
EPA/DHA
- Consult your doctor before taking EPA/DHA if you take warfarin (Coumadin). Taking EPA/DHA with warfarin may increase the risk of bleeding.
- Discontinue using EPA/DHA 2 weeks before any surgical procedure.
Magnesium
- Do not take magnesium if you have kidney failure or myasthenia gravis.
Melatonin
- Do not take melatonin if you are depressed.
- Do not take high doses of melatonin if you are trying to conceive. High doses of melatonin have been shown to inhibit ovulation.
- Melatonin can cause morning grogginess, a feeling of having a hangover or a “heavy head,” or gastrointestinal symptoms such as nausea and diarrhea.
Vitamin B6
- Individuals who are being treated with levodopa without taking carbidopa at the same time should avoid doses of 5 milligrams or greater daily of vitamin B6.
Selenium
- High doses of selenium (1000 micrograms or more daily) for prolonged periods may cause adverse reactions.
- High doses of selenium taken for prolonged periods may cause chronic selenium poisoning. Symptoms include loss of hair and nails or brittle hair and nails.
- Selenium can cause rash, breath that smells like garlic, fatigue, irritability, and nausea and vomiting.
SODzymes
- Do not take SODzymes if you are allergic to soy, corn, or wheat.
Vitamin C
- Do not take vitamin C if you have a history of kidney stones or of kidney insufficiency (defined as having a serum creatine level greater than 2 milligrams per deciliter and/or a creatinine clearance less than 30 milliliters per minute.
- Consult your doctor before taking large amounts of vitamin C if you have hemochromatosis, thalassemia, sideroblastic anemia, sickle cell anemia, or erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency. You can experience iron overload if you have one of these conditions and use large amounts of vitamin C.
Vitamin E
- Consult your doctor before taking vitamin E if you take warfarin (Coumadin).
- Consult your doctor before taking high doses of vitamin E if you have a vitamin K deficiency or a history of liver failure.
- Consult your doctor before taking vitamin E if you have a history of any bleeding disorder such as peptic ulcers, hemorrhagic stroke, or hemophilia.
- Discontinue using vitamin E 1 month before any surgical procedure.
For more information see the Safety Appendix |
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