Sjögren's and Hormone Deficiencies
Restoring dehydroepiandrosterone (DHEA) levels modulates immune and inflammatory responses. Women with primary Sjögren's show decreased serum concentration of DHEA and an increased cortisol/DHEA ratio (Valtysdottir 2001). Because most people over age 35 years are deficient in DHEA, Life Extension believes that patients with Sjögren's should have their DHEA levels tested and if necessary, supplement with this vital hormone. Retesting is recommended 3 to 6 weeks after therapy is initiated to ascertain if optimal DHEA levels have been obtained.
Sjögren's syndrome has also been linked to estrogen deficiencies in menopausal women (Hayashi 2004). While no human studies have been conducted on the value of estrogen restoration therapy among Sjögren's patients, Life Extension believes that women over 35 years should have a complete hormone profile performed and correct any hormonal deficiencies. Women with hormone-dependent cancers, however, are generally advised against hormone restoration with estrogen. Hormone restoration might be especially important among Sjögren's patients who suffer from a disease associated with hormonal deficiencies, even if the mechanism is incompletely understood.