Health Concerns

Life Extension Suggestions

Eat to Live a Long and Healthy Life

Life Extension encourages anyone striving to lose weight to consider adopting a calorie-restricted, but nutrition-dense diet. A detailed explanation of this type of dietary pattern is presented in the Caloric Restriction protocol.

Increase Physical Activity

Increasing physical activity is one of the most effective means of attaining a negative energy balance, which facilitates weight loss. Physical exercise should be undertaken regularly in accordance with one’s overall health and mobility. Anyone with a physical impairment, such as extreme obesity or severe osteoarthritis, should consult a healthcare provider prior to embarking on an exercise regimen. 

Restore Resting Energy Expenditure

  • Green tea extract: 725 – 1450 mg daily with meals
  • Fucoxanthin: 200 mg three times daily
  • Fish oil (with olive polyphenols): providing 1400 mg EPA and 1000 mg DHA daily
  • Cayenne: 600 mg once or twice daily with meals

Restore Healthy Adipocyte (Fat Cell) Signaling

Restore Brain Serotonin / Suppress Hunger Signals

Control Rate of Carbohydrate Absorption and Glucose Synthesis

Pharmaceutical support:

  • Acarbose: 25 – 100 mg before meals

Restore Youthful Hormone Balance

Pharmaceutical support:

  • Natural (bioidentical) hormone replacement therapy (if needed): as directed by an experienced physician
  • Thyroid hormone replacement therapy (if needed): as directed
  • Aromatase inhibitor (if needed; men only): 0.5 mg twice weekly until estradiol levels are between 20 – 30 pg/mL of blood

Restore Insulin Sensitivity

Pharmaceutical support:

  • Metformin: 250 – 850 mg before meals (no more than three times a day)

Inhibit the Lipase Enzyme

Pharmaceutical support:

  • Orlistat (Alli®, Xenical®): 60 – 120 mg before meals (no more than three times daily)

In addition, the following blood testing resource may be helpful:


Disclaimer and Safety Information

This information (and any accompanying material) is not intended to replace the attention or advice of a physician or other qualified health care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease or condition should first consult with and seek clearance from a physician or other qualified health care professional. Pregnant women in particular should seek the advice of a physician before using any protocol listed on this website. The protocols described on this website are for adults only, unless otherwise specified. Product labels may contain important safety information and the most recent product information provided by the product manufacturers should be carefully reviewed prior to use to verify the dose, administration, and contraindications. National, state, and local laws may vary regarding the use and application of many of the treatments discussed. The reader assumes the risk of any injuries. The authors and publishers, their affiliates and assigns are not liable for any injury and/or damage to persons arising from this protocol and expressly disclaim responsibility for any adverse effects resulting from the use of the information contained herein.

The protocols raise many issues that are subject to change as new data emerge. None of our suggested protocol regimens can guarantee health benefits. The publisher has not performed independent verification of the data contained herein, and expressly disclaim responsibility for any error in literature.