DHEA Restoration Therapy

References

Arlt W. Dehydroepiandrosterone and ageing. Best Pract Res Clin Endocrinol Metab . 2004 Sep;18(3):363-80.

Barrett-Connor E, Goodman-Gruen D. The epidemiology of DHEAS and cardiovascular disease. Ann NY Acad Sci . 1995 Dec 29;774:259-70.

Barrett-Connor E, Khaw KT. Absence of an inverse relation of dehydroepiandrosterone sulfate with cardiovascular mortality in postmenopausal women. N Engl J Med . 1987 Sep 10;317(11):711.

Barrett-Connor E, Kritz-Silverstein D. et al. A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women. Am J Epidemiol . 1993 Jan 15;137(2):201-6.

Belaisch J . DHEA: desire and resistance. Gynecol Obstet Fertil . 2002 Dec;30(12):961-9.

Belanger A, Candas B, et al. Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men. J CLin Endocrinol Metab . 1994;79:1086-1090.

Bloch M, Schmidt PJ et al. Dehydroepiandrosterone treatment of midlife dysthymia. Biol Psychiatry . 1999 Jun 15;45(12):1533-41.

Braunstein GD. Androgen insufficiency in women: summary of critical issues. Fertil Steril. 2002;77(4):S94-S99.

Brody S, Carlstrom K. et al. Adrenocortical steroids, bone mineral content and endometrial condition in post-menopausal women. Maturitas . 1982 Aug;4(2):113-22.

Buvat J . Androgen therapy with dehydroepiandrosterone. World J Urol . 2003 Nov;21(5):346-55. Epub 2003 Oct 10.

Cameron DR , Braunstein GD. The use of DHEA therapy in clinical practive. Treat Endocrinol . 2005;4(2):95-114.

Carlstrom K, Brody S. et al. Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex. Maturitas . 1988 Dec;10(4):297-306.

Chang DM, Lan JL. et al. Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial. Arthritis Rheum . 2002 Nov;46(11):2924-7.

Christeff N, Gherbi N. et al. Serum cortisol and DHEA concentrations during HIV infection. Psychoneuroendocrinology . 1997;22(Suppl 1):S11-S18.

Christeff N, Melchior JC. et al. Correlation between increased cortisol:DHEA ratio and malnutrition in HIV-positive men. Nutrition . 1999 Jul;15(7-8):534-9.

Christeff N, Nunez EA. et al. Changes in cortisol/DHEA ratio in HIV-infected men are related to immunological and metabolic perturbations leading to malnutrition and lipodystrophy. Ann NY Acad Sci . 2000;917:962-70.

Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab . 1999 Jun;84(6):1886-91.

Deutsch S, Benjamin F. et al. The correlation of serum estrogens and androgens with bone density in the late postmenopause. Int J Gynaecol Obstet . 1987 Jun;25(3):217-22.

Dhatariya K, Bigelow ML, et al. Effect of DHEA replacement on insulin sensitivity and lipids in hypoadrenal women. Diabetes . 2005 Mar;54(3):765-9.

Dos Santos CD, Toldo MP, et al. Trypanosoma cruzi: the effects of DHEA treatment during experimental infection. Acta Trop. 2005 Aug;95(2):109-15.

Dyner TS, Lang W, et al. An open-label dose-escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. J Acquir Immune Defic Syndr . 1993 May;6(5):459-65.

Dzugan SA , Arnold Smith R . Hypercholesterolemia treatment: a new hypothesis or just an accident? Med Hypotheses. 2002 Dec;59(6):751-6.

Eich DM, Nestler JE, et al. Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation . 1993 Jan;87(1):261-9.

Feldman HA, Johannes CB, et al. Low dehydroepiandrosterone sulfate and heart disease in middle-aged men: cross-sectional results from the Massachusetts Male Aging Study. Ann Epidemiol . 1998 May;8(4):217-28.

Ferrando SJ, Rabkin JG, et al. Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year. J Acquir Immune Defic Syndr . 1999 Oct 1;22(2):146-54.

Ferrari E, Cravello L, et al. Age-related changes of the hypothalamic-pituitary-adrenal axis: pathophysiological correlates. Eur J Endocrinol . 2001 Apr;144(4):319-29.

Ferrari E, Mirani M, et al. Cognitive and affective disorders in the elderly: a neuroendocrine study. Arch Gerontol Geriatr Suppl . 2004;(9):171-82.

Flood JF, Smith GE, et al. Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res . 1988 May 3;447(2):269-78.

Fukui M, Kitagawa Y, et al. Serum DHEA sulfate concentration and carotid atherosclerosis in men with type 2 diabetes. Atherosclerosis . 2005 Aug;181(2):339-44.

Glaser JL, Brind JL, et al. Elevated serum dehydroepiandrosterone sulfate levels in practitioners of the Transcendental Meditation (TM) and TM-Sidhi programs. J Behav Med . 1992 Aug;15(4):327-41.

Gordon GB, Bush DE , et al. Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury. J Clin Invest . 1988 Aug;82(2):712-20.

Haden ST , Glowacki J, et al. Effects of age on serum dehydroepiandrosterone sulfate, IGF-I, and IL-6 levels in women. Calcif Tissue Int . 2000 Jun;66(6):414-8.

Hak AE, Witteman JC, et al. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study. J Clin Endocrinol Metab . 2002 Aug;87(8):3632-9.

Hauffa BP, Kaplan SL, et al. Dissociation between plasma adrenal androgens and cortisol in Cushing's disease and ectopic ACTH-producing tumour: relation to adrenarche. Lancet . 1984 Jun 23;1(8391):1373-6.

Hautanen A, Manttari M, et al. Adrenal androgens and testosterone as coronary risk factors in the Helsinki Heart Study. Atherosclerosis . 1994 Feb;105(2):191-200.

Herbert J. Neurosteroids, brain damage, and mental illness. Exp Gerontol . 1998 Nov;33(7-8):713-27.

Herrington DM, Gordon GB, et al. Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography. J Am Coll Cardiol . 1990 Nov;16(6):862-70.

Hornsby PJ. Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann NY Acad Sci . 1995 Dec 29;774:29-46.

Jacobson MA, Fusaro RE, et al. Decreased serum dehydroepiandrosterone is associated with an increased progression of human immunodeficiency virus infection in men with CD4 cell counts of 200-499. J Infect Dis . 1991 Nov;164(5):864-8.

James K, Premchand N, et al. IL-6, DHEA and the ageing process. Mech Ageing Dev . 1997 Feb;93(1-3):15-24.

Jedrzejuk D, Medras M, et al. Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism. Aging Male . 2003 Sep;6(3):151-6.

Jiang Y, Miyazaki T, et al. Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of DHEA. J Gastroenterol . 2005 May;40(5):490-7.

Johannes CB, Stellato RK, et al. Relation of dehydroepiandrosterone and dehydroepiandrosterone sulfate with cardiovascular disease risk factors in women: longitudinal results from the Massachusetts Women's Health Study. J Clin Epidemiol . 1999 Feb;52(2):95-103.

Kalman DS, Colker CM, et al. A randomized, double-blind, placebo-controlled study of 3-acetyl-oxo-dehydroepiandreosterone in healthy overweight adults. Curr Therap Res . 2000;61(7):435-42.

Kalmijn S, Launer LJ, et al. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J Clin Endocrinol Metab . 1998 Oct;83(10):3487-92.

Kameda W, Daimon M, et al. Association of decrease in serum DHEA-S levels with the progression to type 2 diabetes in men of a Japanese population: the Funagata study. Metabolism . 2005 May;54(5):669-76.

Khalil A, Fortin JP, et al. Age-related decrease of dehydroepiandrosterone concentrations in low density lipoproteins and its role in the susceptibility of low density lipoproteins to lipid peroxidation. J Lipid Res . 2000 Oct;41(10):1552-61.

Khorram O, Vu L, et al. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men. J Gerontol A Biol Sci Med Sci . 1997 Jan;52(1):M1-M7.

Kurzman ID, MacEwen EG, et al. Reduction in body weight and cholesterol in spontaneously obese dogs by dehydroepiandrosterone. Int J Obes . 1990 Feb;14(2):95-104.

Labrie F, Diamond P, et al. Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab . 1997 Oct;82(10):3498-505.

LaCroix AZ , Yano K, et al. Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men. Circulation . 1992 Nov;86(5):1529-35.

Lasco A, Frisina N, et al. Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women. Eur J Endocrinol . 2001 Oct;145(4):457-61.

Laughlin GA , Barrett-Connor E. Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab . 2000 Oct;85(10):3561-8.

Leowattana W. DHEA(S): the fountain of youth. J Med Assoc Thai . 2001 Oct;84(Suppl 2):S605-S612.

Lephart ED, Baxter CR, et al. Effect of burn trauma on adrenal and testicular steroid hormone production. J Clin Endocrinol Metab . 1987 Apr;64(4):842-8

Lubet RA, Gordon GB. et al. Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations. Cancer Res . 1998 Mar 1;58(5):921-6.

Mazat L, Lafont S, et al. Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci USA . 2001 Jul 3;98(14):8145-50.

McCraty R, Barrios-Choplin B, et al. The impact of a new emotional self-management program on stress, emotions, heart rate variability, DHEA and cortisol. Integr Physiol Behav Sci . 1998 Apr;33(2):151-70.

Mitchell LE, Sprecher DL, et al. Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males. Circulation . 1994 Jan;89(1):89-93.

Moore MA, Thamavit W, et al. Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats. Carcinogenesis . 1986 Feb;7(2):311-6.

Morales AJ, Nolan JJ, et al. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab . 1994 Jun;78(6):1360-7.

Morley JE, Kaiser F, et al. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA . 1997 Jul 8;94(14):7537-42.

Murialdo G, Barreca A, et al. Dexamethasone effects on cortisol secretion in Alzheimer's disease: some clinical and hormonal features in suppressor and nonsuppressor patients. J Endocrinol Invest . 2000 Mar;23(3):178-86.

Nafziger AN, Bowlin SJ, et al. Longitudinal changes in dehydroepiandrosterone concentrations in men and women. J Lab Clin Med . 1998 Apr;131(4):316-23.

Nestler JE, Barlascini CO, et al. Absorption characteristic of breakfast determines insulin sensitivity and carbohydrate tolerance for lunch. Diabetes Care . 1988 Nov;11(10):755-60.

Nestler JE, Clore JN, et al. Dehydroepiandrosterone: the "missing link" between hyperinsulinemia and atherosclerosis? FASEB J . 1992 Sep;6(12):3073-5.

Nestler JE, Clore JN, et al. Metabolism and actions of dehydroepiandrosterone in humans. J Steroid Biochem Mol Biol . 1991;40(4-6):599-605.

Nordin BE, Robertson A, et al. The relation between calcium absorption, serum dehydroepiandrosterone, and vertebral mineral density in postmenopausal women. J Clin Endocrinol Metab . 1985 Apr;60(4):651-7.

Nyce JW, Magee PN. et al. Inhibition of 1,2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by dehydroepiandrosterone. Carcinogenesis . 1984 Jan;5(1):57-62.

Orentreich N, Brind JL, et al. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab . 1984 Sep;59(3):551-5.

Osawa E, Nakajima A, et al. Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA). Life Sci . 2002 Apr;70(22):2623-30.

Parker LN, Levin ER, et al. Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Metab . 1985 May;60(5):947-52.

Pavlov EP, Harman SM, et al. Responses of plasma adrenocorticotropin, cortisol, and dehydroepiandrosterone to ovine corticotropin-releasing hormone in healthy aging men. J Clin Endocrinol Metab . 1986 Apr;62(4):767-72.

Pelissier MA, Trap C, et al. Antioxidant effects of dehydroepiandrosterone and 7alpha-hydroxy-dehydroepiandrosterone in the rat colon, intestine and liver. Steroids . 2004 Feb;69(2):137-44.

Porsova-Dutoit I, Sulcova J, et al. Do DHEA/DHEAS play a protective role in coronary heart disease? Physiol Res . 2000;49(Suppl 1):S43-S56.

Rasmuson S, Nasman B, et al. Increased levels of adrenocortical and gonadal hormones in mild to moderate Alzheimer's disease. Dement Geriatr Cogn Disord . 2002;13(2):74-9.

Roberts E, Bologa L, et al. Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice. Brain Res . 1987 Mar 17;406(1-2):357-62.

Ruiz Salmeron RJ, del Arbol JL. et al. [Dehydroepiandrosterone sulfate and lipids in acute myocardial infarct.] Dehidroepiandrosterona-sulfato y lipidos en el infarto agudo de miocardio. Rev Clin Esp . 1992 May;190(8):398-402.

Schmidt PJ, Daly RC, et al. DHEA monotherapy in midlife-onset and minor depression. Arch Gen Psychiatry. 2005 Feb;62(2):154-62.

Schwartz AG, Pashko LL. Cancer chemoprevention with the adrenocortical steroid dehydroepiandrosterone and structural analogs. J Cell Biochem Suppl . 1993;17G:73-9.

Schwartz AG, Pashko LL. Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res Rev . 2004 Apr;3(2):171-87.

Slowinska-Srzednicka J, Zgliczynski S, et al. Decreased plasma dehydroepiandrosterone sulfate and dihydrotestosterone concentrations in young men after myocardial infarction. Atherosclerosis . 1989 Oct;79(2-3):197-203.

Solerte SB, Ferrari E, et al. Decreased release of angiogenic peptide VGEF in Alzheimer's disease: recovering effect with insulin and DHEA-S. Dement Geriatr Cogn Disord. 2005;19(1):1-10.

Stomati M, Monteleone P, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol . 2000 Oct;14(5):342-63.

Straub RH, Konecna L, et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab . 1998 Jun;83(6):2012-7.

Straub RH, Lehle K, et al. Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor. Eur J Endocrinol . 2002a Mar;146(3):365-74.

Sulcova J, Hill M, et al. Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res . 2001;50(1):9-18.

Sullivan KE. The Complex Genetic Basis of Systemic Lupus Erythematosus. Lupus Found Am Lupus News. 1999 Fall;19(4); 1999-2000 Winter;20(1). Available at www.lupus.org.education/articles/geneticbasis.html. Accessed May 24, 2005.

Taelman P, Kaufman JM, et al. Persistence of increased bone resorption and possible role of dehydroepiandrosterone as a bone metabolism determinant in osteoporotic women in late post-menopause. Maturitas . 1989 Mar;11(1):65-73.

Tian WN, Braunstein LD, et al. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem . 1998 Apr 24;273(17):10609-17.

Turna B, Apaydin E, et al. Women with low libido: correlation of decreased androgen levels with female sexual function index. Int J Impot Res . 2005 Mar-Apr;17(2):148-53.

Valenti G. Adrenopause: an imbalance between dehydroepiandrosterone (DHEA) and cortisol secretion. J Endocrinol Invest . 2002;25(10 Suppl):29-35.

Valenti G, Denti L, et al. Effect of DHEAS on skeletal muscle over the life span: the InCHIANTI study. J Gerontol A Biol Sci Med Sci . 2004 May;59(5):466-72.

van Broekhoven F, Verkes RJ. Neurosteroids in depression: a review. Psychopharmacology (Berl) . 2003 Jan;165(2):97-110.

van Vollenhoven RF, Morabito LM, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol . 1998 Feb;25(2):285-9.

Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA . 2004 Nov 10;292(18):2243-8.

Villareal DT, Holloszy JO, et al. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf) . 2000 Nov;53(5):561-8.

Wade CE, Lindberg JS, et al. Upon-admission adrenal steroidogenesis is adapted to the degree of illness in intensive care unit patients. J Clin Endocrinol Metab . 1988 Aug;67(2):223-7.

Wild RA, Buchanan JR, et al. Declining adrenal androgens: an association with bone loss in aging women. Proc Soc Exp Biol Med . 1987 Dec;186(3):355-60.

Williams JR. The effects of dehydroepiandrosterone on carcinogenesis, obesity, the immune system, and aging. Lipids . 2000 Mar;35(3):325-31.

Yaffe K, Ettinger B, et al. Neuropsychiatric function and dehydroepiandrosterone sulfate in elderly women: a prospective study. Biol Psychiatry . 1998 May 1;43(9):694-700.

Yang S, Fu Z, et al. [Anti-mutagenicity activity of dehydroepiandrosterone.] Zhonghua Zhong Liu Za Zhi . 2002 Mar;24(2):137-40.

Yoshida S, Honda A, et al. Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines. Steroids . 2003 Jan;68(1):73-83.

Zenk JL, Kuskowsi MA. The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. Presented at meeting of FASEB, April 17, 2994.