| Cancer: Should
Patients Take Dietary Supplements?
Updated: 07/29/2004
References
Agus DB, Vera JC, Golde DW. Stromal cell oxidation: a mechanism by which
tumors obtain vitamin C. Cancer Res. 1999 Sep 15;59(18):4555-8.
Alderton PM, Gross J, Green MD. Comparative study of doxorubicin, mitoxantrone,
and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity
animal model. Cancer Res. 1992 Jan 1;52(1):194-201.
Almadori G, Bussu F, Galli J, et al. Serum folate and homocysteine levels
in head and neck squamous cell carcinoma. Cancer. 2002 Feb 15;94(4):1006-11.
Amatruda TT, III, Sidell N, Ranyard J, et al. Retinoic acid treatment
of human neuroblastoma cells is associated with decreased N-myc expression.
Biochem Biophys Res Commun. 1985 Feb 15;126(3):1189-95.
Berger M, Habs M, Schmahl D. [Effect of thioctic acid (alpha-limpoic acid)
on the chemotherapeutic efficacy of cyclophosphamide and vincristine sulfate].
Arzneimittelforschung. 1983;33(9):1286-8.
Bland J. Circadian rhythms in antioxidant dosing following chemotherapy.1999;Jun.
Bland J. Nutrition and cancer-scientific basis and clinical applications.
Presented at Comprehensive Cancer Care 2001, ;
see also Bland J., Lord, S., Smith, K. Nutritional support for cancer
patients: a basic program. Presented at Comprehensive Cancer Care 2001,
Arlington , VA , October 19-21, 2001.2001;Arlington, VA, October 19-21,
2001.
Block K. Creating an Integrative Program of Cancer Care. Comprehensive
Cancer Care 2001.2001.
Blumenthal RD, Lew W, Reising A, et al. Anti-oxidant vitamins reduce normal
tissue toxicity induced by radio-immunotherapy. Int J Cancer. 2000 Apr
15;86(2):276-80.
Bracke ME, Depypere HT, Boterberg T, et al. Influence of tangeretin on
tamoxifen's therapeutic benefit in mammary cancer. J Natl Cancer Inst.
1999 Feb 17;91(4):354-9.
Branda RF, Nigels E, Lafayette AR, et al. Nutritional folate status influences
the efficacy and toxicity of chemotherapy in rats. Blood. 1998 Oct 1;92(7):2471-6.
Brock N, Stekar J, Pohl J, et al. Acrolein, the causative factor of urotoxic
side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.
Arzneimittelforschung. 1979;29(4):659-61.
Cairns P, Esteller M, Herman JG, et al. Molecular detection of prostate
cancer in urine by GSTP1 hypermethylation. Clin Cancer Res. 2001 Sep;7(9):2727-30.
Cameron E, Pauling L, Leibovitz B. Ascorbic acid and cancer: a review.
Cancer Res. 1979 Mar;39(3):663-81.
Carter CA, Pogribny M, Davidson A, et al. Effects of retinoic acid on
cell differentiation and reversion toward normal in human endometrial
adenocarcinoma (RL95-2) cells. Anticancer Res. 1996 Jan;16(1):17-24.
Chen H, Liu J, Merrick BA, et al. Genetic events associated with arsenic-induced
malignant transformation: applications of cDNA microarray technology.
Mol Carcinog. 2001 Feb;30(2):79-87.
Chinery R, Brockman JA, Peeler MO, et al. Antioxidants enhance the cytotoxicity
of chemotherapeutic agents in colorectal cancer: a p53-independent induction
of p21WAF1/CIP1 via C/EBPbeta. Nat Med. 1997 Nov;3(11):1233-41.
Cohen M, Bhagavan HN. Ascorbic acid and gastrointestinal cancer. J Am
Coll Nutr. 1995 Dec;14(6):565-78.
Cole WC, Prasad KN. Contrasting effects of vitamins as modulators of apoptosis
in cancer cells and normal cells: a review. Nutr Cancer. 1997;29(2):97-103.
Delaney TF, Afridi N, Taghian AG, et al. 13-cis-retinoic acid with alpha-2a-interferon
enhances radiation cytotoxicity in head and neck squamous cell carcinoma
in vitro. Cancer Res. 1996 May 15;56(10):2277-80.
Dovinova I, Novotny L, Rauko P, et al. Combined effect of lipoic acid
and doxorubicin in murine leukemia. Neoplasma. 1999;46(4):237-41.
Dreno B. Roferon-A (interferon alpha 2a) combined with Tigason (etretinate)
for treatment of cutaneous T cell lymphomas. Stem Cells. 1993 Jul;11(4):269-75.
Fenech M. Recommended dietary allowances (RDAs) for genomic stability.
Mutat Res. 2001 Sep 1;480-481:51-4.
Garewal H. Beta-carotene and antioxidant nutrients in oral cancer prevention.
In Nutrients in Cancer Prevention and Treatment 1995.1995:235-47.
Goessl C, Muller M, Heicappell R, et al. DNA-based detection of prostate
cancer in blood, urine, and ejaculates. Ann N Y Acad Sci. 2001 Sep;945:51-8.
Hazuka MB, Edwards-Prasad J, Newman F, et al. Beta-carotene induces morphological
differentiation and decreases adenylate cyclase activity in melanoma cells
in culture. J Am Coll Nutr. 1990 Apr;9(2):143-9.
Hoffer A. [Asymmetry and mutuality in the analytic relationship: lessons
for today from the relationship between Freud and Ferenczi]. Psyche (Stuttg).
1993 Nov;47(11):1027-40.
Hoffer A. Isoniazid and pyridoxine. CMAJ. 1993 Nov 1;149(9):1232.
Hoffer A, Chang CY, Puga A. Dioxin induces transcription of fos and jun
genes by Ah receptor-dependent and -independent pathways. Toxicol Appl
Pharmacol. 1996 Nov;141(1):238-47.
Hoffer A. One patient's recovery from lymphoma. Townsend Letter for Doctors
and Patients.1996 160:50-1.
Hoffer APL. Hardin Jones biostatistical analysis of morality data for
cohorts of cancer patients with a large fraction surviving at the termination
of the study and a comparison of survival times of cancer patients receiving
large regular oral doses of vitamin C and other nutrients with similar
patients not receiving those doses. - reprinted in Cameron, E., Pauling,
L. Cancer and Vitamin C. J Orthomol Med. 1993;(5):143-54-199.
Hoffer APL. Hardin Jones biostatistical analysis of mortality data for
a second set of cohorts of cancer patients with a large fraction surviving
at the termination of the study and a comparison of survival time of cancer
patients receiving large regular oral doses of vitamin C and other nutrients
with similar patients not receiving these doses. J Orthomol Med. 1993;(8):1547-67.
Israel K, Yu W, Sanders BG, et al. Vitamin E succinate induces apoptosis
in human prostate cancer cells: role for Fas in vitamin E succinate-triggered
apoptosis. Nutr Cancer. 2000;36(1):90-100.
Issa JP, Baylin SB, Belinsky SA. Methylation of the estrogen receptor
CpG island in lung tumors is related to the specific type of carcinogen
exposure. Cancer Res. 1996 Aug 15;56(16):3655-8.
Jaakkola K, Lahteenmaki P, Laakso J, et al. Treatment with antioxidant
and other nutrients in combination with chemotherapy and irradiation in
patients with small-cell lung cancer. Anticancer Res. 1992 May;12(3):599-606.
Jatoi A, Daly BD, Kramer G, et al. A cross-sectional study of vitamin
intake in postoperative non-small cell lung cancer patients. J Surg Oncol.
1998 Aug;68(4):231-6.
Jha MN, Bedford JS, Cole WC, et al. Vitamin E (d-alpha-tocopheryl succinate)
decreases mitotic accumulation in gamma-irradiated human tumor, but not
in normal, cells. Nutr Cancer. 1999;35(2):189-94.
Kal'nev VR, Rachkus I, Kanopkaite SI. [Influence of methylcobalamin and
cyanocobalamin on the neoplastic process in rats]. Prikl Biokhim Mikrobiol.
1977 Sep;13(5):677-81.
Kim DH, Nelson HH, Wiencke JK, et al. p16(INK4a) and histology-specific
methylation of CpG islands by exposure to tobacco smoke in non-small cell
lung cancer. Cancer Res. 2001 Apr 15;61(8):3419-24.
Kreienberg R. [Therapy of anthracycline-resistant metastatic breast carcinoma].
Schweiz Rundsch Med Prax. 1998 Apr 22;87(17):573-7.
Kuan YM, Dear E, Grigg MJ. Homocysteine: an aetiological contributor to
peripheral vascular arterial disease. ANZ J Surg. 2002 Sep;72(9):668-71.
Kumar B, Jha MN, Cole WC, et al. D-alpha-tocopheryl succinate (vitamin
E) enhances radiation-induced chromosomal damage levels in human cancer
cells, but reduces it in normal cells. J Am Coll Nutr. 2002 Aug;21(4):339-43.
Kurihara H, Koda H, Asami S, et al. Contribution of the antioxidative
property of astaxanthin to its protective effect on the promotion of cancer
metastasis in mice treated with restraint stress. Life Sci. 2002 Apr 21;70(21):2509-20.
Labriola D, Livingston R. Possible interactions between dietary antioxidants
and chemotherapy. Oncology (Huntingt). 1999 Jul;13(7):1003-8.
Lamm DL, Riggs DR, Shriver JS, et al. Megadose vitamins in bladder cancer:
a double-blind clinical trial. J Urol. 1994 Jan;151(1):21-6.
Lamson DW, Brignall MS. Antioxidants in cancer therapy; their actions
and interactions with oncologic therapies. Altern Med Rev. 1999 Oct;4(5):304-29.
Lamson DW, Brignall MS. Antioxidants and cancer therapy II: quick reference
guide. Altern Med Rev. 2000 Apr;5(2):152-63.
Letur-Konirsch H, Guis F, Delanian S. Uterine restoration by radiation
sequelae regression with combined pentoxifylline-tocopherol: a phase II
study. Fertil Steril. 2002 Jun;77(6):1219-26.
Lippman SM, Kavanagh JJ, Paredes-Espinoza M, et al. 13-cis-retinoic acid
plus interferon-alpha 2a in locally advanced squamous cell carcinoma of
the cervix. J Natl Cancer Inst. 1993 Mar 17;85(6):499-500.
Lippman SMPDRILM. 13-cis-Retinoic acid plus interferon -2a: highly active
systemic therapy for squamous cell carcinoma of the cervix. J Natl Cancer
Inst. 1995;(84):241-5.
Loehrer FM, Angst CP, Haefeli WE, et al. Low whole-blood S-adenosylmethionine
and correlation between 5-methyltetrahydrofolate and homocysteine in coronary
artery disease. Arterioscler Thromb Vasc Biol. 1996 Jun;16(6):727-33.
Loffler TM, Korsten FW, Reis HE, et al. [Fluorouracil as monotherapy or
combined with folinic acid in the treatment of metastasizing colorectal
carcinoma]. Dtsch Med Wochenschr. 1992 Jun 26;117(26):1007-13.
Mahoney CW, Azzi A. Vitamin E inhibits protein kinase C activity. Biochem
Biophys Res Commun. 1988 Jul 29;154(2):694-7.
Malafa MPNLT. Vitamin E succinate promotes breast cancer dormancy and
inhibits VEGF gene expression. Paper presented at the International Congress
on Frontiers of Pharmacology and Therapeutics in the 21st Century, New
Delhi, India, December 1999, pp. 15-9.1999;December 1999,15-9.
Malmberg KJ, Lenkei R, Petersson M, et al. A short-term dietary supplementation
of high doses of vitamin E increases T helper 1 cytokine production in
patients with advanced colorectal cancer. Clin Cancer Res. 2002 Jun;8(6):1772-8.
Mehta MP. Protection of normal tissues from the cytotoxic effects of radiation
therapy: focus on amifostine. Semin Radiat Oncol. 1998 Oct;8(4 Suppl 1):14-6.
Meyskens FL, Jr. Role of vitamin A and its derivatives in the treatment
of human cancer. In Nutrients in Cancer Prevention and Treatment 1995.2004:349-62.
Mills EE. The modifying effect of beta-carotene on radiation and chemotherapy
induced oral mucositis. Br J Cancer. 1988 Apr;57(4):416-7.
Momparler RL, Ayoub J. Potential of 5-aza-2'-deoxycytidine (Decitabine)
a potent inhibitor of DNA methylation for therapy of advanced non-small
cell lung cancer. Lung Cancer. 2001 Dec;34 Suppl 4:S111-S115.
Morrow M. Does vitamin E prevent breast cancer? Life Extension Magazine
2002 May. 2002; 2002 May8(5):29-32.
Moss RW. Questioning Chemotherapy.1995.
Motycka K, Balcarova A. Methotrexate and folic acid effect in normal and
sarcoma 180 bearing mice. Neoplasma. 1975;22(5):507-18.
Park CH. Vitamin C in leukemia and preleukemia cell growth. Prog Clin
Biol Res. 1988;259:321-30.
Pathak AK, Singh N, Khanna N, et al. Potentiation of the effect of paclitaxel
and carboplatin by antioxidant mixture on human lung cancer h520 cells.
J Am Coll Nutr. 2002 Oct;21(5):416-21.
Pathak S. A preliminary clinical trial in patients with non-small cell
lung carcinoma (carboplatin and Taxol together with high doses of vitamin
C, vitamin E, and beta-carotene vs. carboplatin and Taxol alone) (unpublished
data).7777;unpublished data.
Poydock ME. Effect of combined ascorbic acid and B-12 on survival of mice
with implanted Ehrlich carcinoma and L1210 leukemia. Am J Clin Nutr. 1991
Dec;54(6 Suppl):1261S-5S.
Prasad KN, Sinha PK, Ramanujam M, et al. Sodium ascorbate potentiates
the growth inhibitory effect of certain agents on neuroblastoma cells
in culture. Proc Natl Acad Sci U S A. 1979 Feb;76(2):829-32.
Prasad KN, Edwards-Prasad J. Effects of tocopherol (vitamin E) acid succinate
on morphological alterations and growth inhibition in melanoma cells in
culture. Cancer Res. 1982 Feb;42(2):550-5.
Prasad KN, Edwards-Prasad J. Expressions of some molecular cancer risk
factors and their modification by vitamins. J Am Coll Nutr. 1990 Feb;9(1):28-34.
Prasad KN, Hernandez C, Edwards-Prasad J, et al. Modification of the effect
of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma
cells in culture by a mixture of vitamins. Nutr Cancer. 1994;22(3):233-45.
Prasad KN, Kumar R. Effect of individual and multiple antioxidant vitamins
on growth and morphology of human nontumorigenic and tumorigenic parotid
acinar cells in culture. Nutr Cancer. 1996;26(1):11-9.
Prasad KN, Cole W, Hovland P. Cancer prevention studies: past, present,
and future directions. Nutrition. 1998 Feb;14(2):197-210.
Prasad KN, Kumar A, Kochupillai V, et al. High doses of multiple antioxidant
vitamins: essential ingredients in improving the efficacy of standard
cancer therapy. J Am Coll Nutr. 1999 Feb;18(1):13-25.
Prasad KN, Cole WC, Kumar B, et al. Scientific rationale for using high-dose
multiple micronutrients as an adjunct to standard and experimental cancer
therapies. J Am Coll Nutr. 2001 Oct;20(5 Suppl):450S-63S.
Salganik RACRJ. Enhancement of apoptosis and inhibion of brain tumor growth
in transgenic mice by depletion of antioxidants. American Society for
Cell Biology Annual Meeting. Am Soc Cell Biol. 1999.
Salganik RI, Albright CD, Rodgers J, et al. Dietary antioxidant depletion:
enhancement of tumor apoptosis and inhibition of brain tumor growth in
transgenic mice. Carcinogenesis. 2000 May;21(5):909-14.
Salganik RI. The benefits and hazards of antioxidants: controlling apoptosis
and other protective mechanisms in cancer patients and the human population.
J Am Coll Nutr. 2001 Oct;20(5 Suppl):464S-72S.
Sasaki M, Dharia A, Oh BR, et al. Progesterone receptor B gene inactivation
and CpG hypermethylation in human uterine endometrial cancer. Cancer Res.
2001 Jan 1;61(1):97-102.
Schwartz JL. Molecular and biochemical control of tumor growth following
treatment with carotenoids or tocopherols. In Nutrients in Cancer Prevention
and Treatment.1995:287-316.
Seifter ERAPJLSM. Vitamin A and ß-carotene as adjunctive therapy
to tumor excision, radiation therapy and chemotherapy. In Vitamins, Nutrition
and Cancer 1984, pp. 1-19.1984:1-19.
Shimizu N, Hamazoe R, Kanayama H, et al. Experimental study of antitumor
effect of methyl-B12. Oncology. 1987;44(3):169-73.
Simone C. Antioxidants with Radiation and Chemotherapy? 2000. Comprehensive
Cancer Care 2001.2000;2001.
Somasundaram S, Edmund NA, Moore DT, et al. Dietary curcumin inhibits
chemotherapy-induced apoptosis in models of human breast cancer. Cancer
Res. 2002 Jul 1;62(13):3868-75.
Sporn MB, Roberts AB. Role of retinoids in differentiation and carcinogenesis.
Cancer Res. 1983 Jul;43(7):3034-40.
Tallberg T, Uusitalo R, Sarna S, et al. Improvement of the recurrence-free
interval using biological adjuvant therapy in uveal melanoma. Anticancer
Res. 2000 May;20(3B):1969-75.
Turley JM, Sanders BG, Kline K. Vitamin E succinate induction of HL-60
cell adhesion: a role for fibronectin and a 72-kDa fibronectin-binding
molecule. Nutr Cancer. 1995;23(1):43-54.
Weihrauch M, Benicke M, Lehnert G, et al. Frequent k- ras -2 mutations
and p16(INK4A)methylation in hepatocellular carcinomas in workers exposed
to vinyl chloride. Br J Cancer. 2001 Apr 6;84(7):982-9.
Wilcken DE, Dudman NP, Tyrrell PA. Homocystinuria due to cystathionine
beta-synthase deficiency--the effects of betaine treatment in pyridoxine-responsive
patients. Metabolism. 1985 Dec;34(12):1115-21.
Yi P, Melnyk S, Pogribna M, et al. Increase in plasma homocysteine associated
with parallel increases in plasma S-adenosylhomocysteine and lymphocyte
DNA hypomethylation. J Biol Chem. 2000 Sep 22;275(38):29318-23. |