Mega GLA with Sesame Lignans

60 softgels, Item# 00756

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  • Mega GLA with Sesame Lignans
  • 60 softgels
  • Item Catalog Number: 00756

The body needs fatty acids to survive and is able to make all but two of them: linoleic acid (LA), in the omega-6 family, and alpha-linolenic acid (ALA) in the omega-3 family. These two fatty acids must be supplied by the diet and are therefore considered essential fatty acids (EFAs).

Omega-6 fatty acids are well-supplied in the diet by meat and vegetable oils. However, not all omega-6 fatty acids are of equal value. Arachidonic acid (AA) tends to be unhealthy because it is the precursor of inflammatory eicosanoids — such as prostaglandin E2 (PGE2), thromboxane A2, and leukotriene B4 — which promote inflammation. In contrast, gamma-linolenic acid (GLA), found in evening primrose oil, borage oil, and black currant oil, is an important fatty acid that plays a beneficial role in healthy prostaglandin (PGE1) formation and pro-inflammatory mediator reduction.98,99

Health-conscious people have been swallowing a lot of borage oil supplements to obtain GLA (gamma linolenic acid), the parent of the biologically active DGLA (dihomogamma linolenic acid).

Life Extension adds 10 mg of sesame lignans to each softgel of Mega GLA borage oil. Sesame lignans not only increase beneficial DGLA but they also impede the conversion of GLA into the proinflammatory mediator arachidonic acid.147 Blocking this pathway decreases the formation of proinflammatory agents prostaglandin E2 and leukotriene B4.148

Numerous studies document GLA’s multiple health effects. Enhancing this supplement with sesame lignans enables GLA to work much better in the body, allowing many more people to benefit from supplemental GLA.

Supplement Facts

Serving Size 1 softgel

Amount Per Serving



Calories from fat


Total Fat

1.5 g

Saturated fat

0 g

Borage seed oil supplying 299 mg gamma-linolenic acid (GLA)

1360 mg

Sesame seed lignan extract

10 mg

Other ingredients: gelatin, glycerin, purified water, silica, sunflower lecithin, carob color, rosemary extract.


Dosage and Use
  • Take one softgel (1) one to two times daily with food, or as recommended by a healthcare practitioner.
  • Up to five (5) softgels can be taken daily.

If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.