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Human Epididymis Protein 4 (HE4) is used as an aid in monitoring recurrence of progressive disease in women with epithelial ovarian cancer. It should not be used for monitoring women with mucinous or germ cell ovarian cancer. Combining CA125 and HE4 provides a more accurate predictor of malignancy than either alone.1
HE4 should not be used for cancer screening.
Fasting is not required. Take all medications as prescribed.
1. Hellstrom I, Hellstrom KE, "SMRP and HE4 as Biomarkers for Ovarian Carcinoma When Used Alone and in Combination With CA125 and/or Each Other," Adv Exp Med Biol, 2008, 622:15-21. PubMed 18546615